Depending on the normality of data as determined by the Shapiro–Wilk test, the paired t-test or the Wilcoxon signed-rank test was used to analyze changes (T1-T0) in the cephalometric and dental arch morphology measurements and MLF within each group. The independent t-test or the Mann–Whitney U test was used to compare pretreatment variables (T0) and changes (T1–T0) in the cephalometric and dental arch variables and MLF between the two groups. Pearson's correlation analysis was used to verify the associations between dentoskeletal changes and changes in MLF. All statistical analyses were performed using IBM SPSS Statistics ver. 22.0 for Windows (IBM Corp., Armonk, NY, USA). A p-value for < 0.05 was considered statistically significant.
A high degree of reliability was found for all measurements. The mean intraclass correlation coefficients (95% confidence interval) for the cephalometric measurements, arch depth, intercanine width, intermolar width, and MLF were 0.941 (0.781 to 0.999), 0.987 (0.979 to 0.992), 0.997 (0.995 to 0.998), 0.994 (0.989 to 0.996), and 0.932 (0.890 to 0.958), respectively (p < 0.001 for all).