All Florbetapir-PET scans were acquired in a single session on a Philips Gemini GXL CT-PET scanner 50 (± 5) min after injection of approximately 370 MBq (333–407 MBq) of Florbetapir. Images acquisition, reconstruction including correction algorithms and reallination, averaging, and quality check were performed by the CATI team (Centre d’Acquisition et Traitement des Images) (http://cati-neuroimaging.com ) [19 (link), 24 (link), 25 (link)] and were calculated for each of 12 cortical regions of interest (right and left posterior cingulate, right and left anterior cingulate, right and left superior frontal, right and left inferior parietal, right and left precuneus, right and left middle temporal cortices), as well as the global average standard uptake value ratio (SUVR).
Gemini gxl pet ct scanner
Manufactured by Philips
The Gemini GXL PET/CT scanner is a medical imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to acquire high-quality images of the human body for diagnostic and research purposes.
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6 protocols using gemini gxl pet ct scanner
1
Florbetapir-PET Imaging Protocol
2
Florbetapir-PET Imaging Protocol
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All florbetapir-PET scans were acquired in a single session on a Philips Gemini GXL CT-PET scanner 50 (± 5) minutes after injection of approximately 370 MBq (333–407 MBq) of Florbetapir. PET acquisition consisted of 3 × 5 min frames, a 128 × 128 acquisition matrix and a voxel size of 2 × 2 × 2 mm3. Images were then reconstructed using iterative LOR-RAMLA algorithm (10 iterations), with a smooth post-reconstruction filter. All corrections (attenuation, scatter, and random coincidence) were integrated in the reconstruction. Lastly, frames were realigned, averaged and quality-checked by the CATI team (http://cati-neuroimaging.com ).
3
Standardized Approach for PET/CT Imaging
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All patients were required to fast for 6–8 hours, and venous blood glucose levels were controlled to less than 8.0 mmol/L. In the patient’s dorsal or elbow vein, 3.7–7.4 MBq/kg of [18F]F-FDG isotope (HM-12, Sumitomo Heavy Industries Ltd., Tokyo, Japan, radiochemical purity > 95%) was intravenously injected. After urinating in quiet, light-avoidance conditions (60 ± 5 min), the PET/CT images were acquired using a 16-slice Gemini GXL PET/CT scanner (Philips Medical System). A low-dose CT scan (tube voltage: 120 kV, tube current: 50 mAs, slice thickness: 5.0 mm, pitch: 1.0) was acquired for attenuation correction, and then the PET images were acquired (1.5 min per bed position, 6–7 PET bed positions). According to the agency’s standard clinical protocols, the scan range was from the head to the mid-thigh. The line of response reconstruction algorithm was used to reconstruct the image without post-reconstruction filtering after automatic random and scattering correction.
4
Standardized Whole-Body 18F-FDG PET/CT Imaging
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Standard whole-body 18F-FDG PET/CT was performed using a Gemini GXL PET/CT scanner (Philips, Amsterdam, The Netherlands). Fasting for at least 6 hours was required before the examination, and the blood glucose level was measured immediately before the administration of 18F-FDG. The PET/CT scan would be rescheduled if the blood glucose level was >150 mg/dL. Approximately 5 MBq of 18F-FDG per kilogram of body weight was administered intravenously, and the patients rested in a quiet, dark environment for approximately 60 minutes before scanning. After initial low-dose CT (40 mA, 120 kVp), emission images were obtained from the top of the skull to the middle of the thigh, with acquisition times of 2 minutes per bed position in the three-dimensional mode. The PET images were reconstructed iteratively with CT-based attenuation correction (Figures 1 and 2 ).
5
In-house Production and PET Imaging of (R)-[11C]PK11195
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(R)-[11C]PK11195 PET was produced in-house according to published methods.51 (link) A Philips Gemini GXL PET/CT scanner (Philips Medical Systems, Best, the Netherlands) was used to perform dynamic 3D PET scans of the entire brain (90 slices, 2 mm slice sampling) and a low-dose brain CT scan for attenuation correction. PET acquisition started immediately after the intravenous bolus injection of a maximum of 370 MBq of (R)-[11C]PK11195. Scans were acquired over 60 min (22 frames: 4 × 30 s + 4 × 60 s + 4 × 120 s + 4 × 240 s + 6 × 300 s). PET data were reconstructed using a LOR-RAMLA algorithm, with attenuation and scatter corrections.
6
PET/CT Imaging of FAP-Targeted Tracer
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No patients were required to fast, and venous blood glucose levels were not controlled. Radioactivity ranging from 129.5 to 148 MBq of Al18F-NOTA-FAPI-04 isotope (Jiangyuan Industrial technology trade Co., Ltd., Jiangsu, China, radiochemical purity > 95%) was intravenously injected. After urinating in quiet, light-avoidance conditions (15 min), the PET/CT images were acquired using a 16-slice Gemini GXL PET/CT scanner (Philips Medical System). A low-dose CT scan (tube voltage: 120 kV, tube current: 50 mAs, slice thickness: 5.0 mm, pitch: 1.0) was acquired for attenuation correction, and then the PET images were acquired (1.5 min per bed position, 6–7 PET bed positions). According to the agency’s standard clinical protocols, the scan range was from the head to the mid-thigh. The line of response reconstruction algorithm was used to reconstruct the image without post-reconstruction filtering after automatic random and scattering correction.
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