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Human database

Manufactured by Chemical Computing Group
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The Human Database is a laboratory equipment product that serves as a data storage and retrieval system for human-related information. It provides a secure and organized way to collect, maintain, and access data pertaining to human subjects or participants in research or other studies.

Automatically generated - may contain errors

Lab products found in correlation

Moe software, by Chemical Computing Group (3 mentions)

3 protocols using human database

1

Antibody Sequence Alignment and Clustering

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 4

The Molecular Operating Environment (MOE) software developed by Chemical Computing Group (CCG) are used to generate alignments between the rabbit antibody clone 132, clone 154 and clone 163 and pairs of variable light and heavy chains, VL and VH, respectively from two databases:

    • (1) The Abysis human database: a database of about 2000 known human VL/VH sequence pairs from IMGT-LigM DB; and
    • (2) A human germline database: a database of germline sequences.

Humanized models show the best sequence alignments (highest identity to both the VL and VH domains) with fewest gaps. The top 100 antibody pairs from each human database are exported and clustered using kClust (Hauser, Mayer, & Soding, (2013) BMC Bioinformatics, 248).

US11834654B2. Antigen binding molecules and methods of use thereof (2023-12-05). Kite Pharma, Inc. [US]. Inventors: Jed J. W. Wiltzius [US], Stuart A. Sievers [US].
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2

Antibody Sequence Alignment and Clustering

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 4

The Molecular Operating Environment (MOE) software developed by Chemical Computing Group (CCG) are used to generate alignments between the rabbit antibody clone 132, clone 154 and clone 163 and pairs of variable light and heavy chains, VL and VH, respectively from two databases:

(1) The Abysis human database: a database of about 2000 known human VL/VH sequence pairs from IMGT-LigM DB; and

(2) A human germline database: a database of germline sequences.

Humanized models show the best sequence alignments (highest identity to both the VL and VH domains) with fewest gaps. The top 100 antibody pairs from each human database are exported and clustered using kClust (Hauser, Mayer, & Soding, (2013) BMC Bioinformatics, 248).

US10844371B2. Antigen binding molecules and methods of use thereof (2020-11-24). Kite Pharma, Inc. [US]. Inventors: Jed J. W. Wiltzius [US], Stuart A. Sievers [US].
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3

Humanizing Rabbit Antibody Sequences

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 3

The Molecular Operating Environment (MOE) software developed by Chemical Computing Group (CCG) may be used to generate alignments between the rabbit antibody clones and pairs of variable light and heavy chains, VL and VH, respectively from two databases:

    • (1) The Abysis human database: a database of about 2000 known human VL/VH sequence pairs from IMGT-LigM DB; and
    • (2) A human germline database: a database of germline sequences.

Humanized models show the best sequence alignments (highest identity to both the VL and VH domains) with fewest gaps. The top 100 antibody pairs from each human database are exported and clustered using kClust (Hauser, Mayer, & Soding, (2013) BMC Bioinformatics, 248).

US11820823B2. T cell receptor antigen binding molecules and methods of use thereof (2023-11-21). Kite Pharma, Inc. [US]. Inventors: Stephanie Astrow [US], Stuart Sievers [US], Jed Wiltzius [US].
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