Diclazuril

Manufactured by Merck Group

Sourced in United States, Germany, Sao Tome and Principe

Diclazuril is a chemical compound used in the production of various laboratory and research equipment. It serves as a core component in the manufacturing process of certain lab instruments and devices. The specific function and intended use of Diclazuril should be further investigated by the relevant scientific and technical personnel.

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Lab products found in correlation

Tbbpa, by Merck Group (1 mentions) Oxibendazole, by Merck Group (1 mentions) Lincomycin, by Merck Group (1 mentions) Spiramycin, by Merck Group (1 mentions) Narasin, by Merck Group (1 mentions) Tiamulin, by Merck Group (1 mentions) Monensin, by Merck Group (1 mentions) Amoxicillin, by Merck Group (1 mentions)

3 protocols using diclazuril

Oral Delivery of TBBPA and Diclazuril

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TBBPA (Sigma) was delivered by oral gavage in corn oil containing 2% Et-OH as a saline suspension, in a dose of 150 mg/bwkg/day as described [27 (link)]. The treatment lasted 6 days, and control animals received the vehicle. Diclazuril (Sigma-Aldrich, St. Louis, MO, USA) was delivered by oral gavage in a dose of 10.0 mg/bwkg/day as a saline suspension as described [44 (link)]. Diclazuril treatment lasted 5 days, and control animals received the vehicle. Following the last treatment, the animals were sacrificed by decapitation, and trunk blood was collected. Peripheral tissues and brain regions were harvested and flash-frozen in dry ice. The PVN and ARC-ME regions were microdissected with the Palkovits punch technique; bone was collected from the distal part of the tibia and skeletal muscle was collected from musculus gastrocnemius. Treatment for in vivo imaging was continued for 14 days, followed by a 7-day-long withdrawal.

Sinkó R., Rada K., Kollár A., Mohácsik P., Tenk M., Fekete C, & Gereben B. (2022). Tetrabromobisphenol A and Diclazuril Evoke Tissue-Specific Changes of Thyroid Hormone Signaling in Male Thyroid Hormone Action Indicator Mice. International Journal of Molecular Sciences, 23(23), 14782.

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DESI Optimization for Veterinary Drugs

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Nine veterinary drugs were used as model standards for the optimization of DESI parameters. Diclazuril (DIC), narasin (NAR), monensin (MON) oxibendazole (OXI), amoxicillin (AMO), lincomycin (LIN), tiamulin (TIA) and spiramycin (SPI) were purchased from Sigma-Aldrich (Steinheim, Germany) while tylosin (TYL) was purchased from Rikilt (Wageningen, Netherlands). All the standards were of the highest purity available. LC-MS grade methanol (MeOH), acetonitrile (ACN) and water were supplied by Sigma-Aldrich (Steinheim, Germany) as well as formic acid (≥99%).
Nitrogen (99.9995% purity) used for nebulization gas was supplied by Linde Group (Barcelona, Spain). Individual stock solutions (1 mg mL -1 ) were prepared in MeOH and stored at 4°C, while the working standard mixtures were prepared weekly by appropriate dilution in ACN.

Seró R., Núñez O., Bosch J., Grases J.M., Rodríguez P., Moyano E, & Galceran M.T. (2015). Desorption electrospray ionization-high resolution mass spectrometry for the screening of veterinary drugs in cross-contaminated feedstuffs. Analytical and bioanalytical chemistry, 407(24).

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Diclazuril Medication in Mouse Model

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Diclazuril (Sigma-Aldrich, St. Louis, Missouri and LKT Laboratories, St. Paul, Minnesota) was compounded into 5LG4 rat and mouse chow (Test Diet, St. Louis, Missouri) at a concentration of 50 ppm. Medicated chow provided 10 mg of Diclazuril/kg of body weight to each mouse, a dose previously shown to prevent the development of S. neurona-associated disease in Ifnc À/À mice (Dubey et al., 2001) . The rat and mouse chow (5LG4), without Diclazuril, served as the control diet.

Hay A.N., Witonsky S.G., Lindsay D.S., LeRoith T., Zhu J., Kasmark L, & Leeth C.M. (2019). Sarcocystis neurona-Induced Myeloencephalitis Relapse Following Anticoccidial Treatment. The Journal of parasitology, 105(2).

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