2.7m array

Manufactured by Thermo Fisher Scientific

The 2.7M array is a high-density microarray product for genomic analysis. It features over 2.7 million probes to enable comprehensive coverage of the human genome. The array is designed for applications such as genome-wide association studies, copy number variation analysis, and expression profiling.

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Whole-Genome 2.7M Array

2 protocols using 2.7m array

Chromosome 17q24 Breakpoint Mapping

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Breakpoint mapping was performed using FISH with BAC clones in the chromosome 17q24 region. To fine map the deleted region on chromosome 17q, genome scanning was initially performed using the Affymetrix 500k whole-genome mapping array, and then the 2.7M array (Affymetrix) to further examine CNVs in the region of the breakpoint.

DeStefano G.M., Kurban M., Anyane-Yeboa K., Dall'Armi C., Di Paolo G., Feenstra H., Silverberg N., Rohena L., López-Cepeda L.D., Jobanputra V., Fantauzzo K.A., Kiuru M., Tadin-Strapps M., Sobrino A., Vitebsky A., Warburton D., Levy B., Salas-Alanis J.C, & Christiano A.M. (2014). Mutations in the Cholesterol Transporter Gene ABCA5 Are Associated with Excessive Hair Overgrowth. PLoS Genetics, 10(5), e1004333.

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Determining Unbalanced Translocation Breakpoints

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Translocation breakpoints were determined by microarray analysis on DNA from products of conception. The unbalanced translocation enabled breakpoints to be determined by ascertaining the transition between probes on the array with normal copy number (Log₂ ratio = 0.0) and those with an amplified signal representing the duplication (theoretical Log₂ ratio = 0.58). The initial breakpoints were determined using NimbleGen 135K v2.0 CGH array and refined further using high resolution Affymetrix 2.7M array.

Huq A., Pertile M., Davis A., Landon H., James P., Kline C., Vohra J., Mohler P, & Delatycki M. (2016). A Novel Mechanism for Human Cardiac Ankyrin-B Syndrome due to Reciprocal Chromosomal Translocation. Heart, lung & circulation, 26(6), 612-618.

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