Salmeterol

Manufactured by Bio-Techne

Salmeterol is a laboratory equipment product manufactured by Bio-Techne. It is a selective beta2-adrenergic receptor agonist used for research purposes.

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Lab products found in correlation

Nadolol, by Merck Group (1 mentions) Phentolamine hydrochloride, by Merck Group (1 mentions) Atenolol, by Merck Group (1 mentions) Norepinephrine bitartrate, by Merck Group (1 mentions) Mp150, by Biopac (1 mentions) Ventolin, by GlaxoSmithKline (1 mentions) Isometric force transducer, by Harvard Apparatus (1 mentions)

2 protocols using salmeterol

Adrenergic and Cholinergic Receptor Modulation

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Phentolamine hydrochloride (Sigma, P7547), nadolol (Sigma, N1892), atenolol (Sigma, A7655), and ICI-118,551 hydrochloride (SelleckChem, 0821), were used in this study as antagonists for different adrenergic receptors and were dissolved in milliQ water and filter-sterilized. Three different ADRB2 agonists were used. Norepinephrine bitartrate (Sigma, A0937) was dissolved in complete IMDM supplemented with 10% FBS. Albuterol (Salbutamol sulfate, SelleckChem, S2507) was dissolved in either DMSO (Fig. 2C) or complete IMDM supplemented with 10% FBS (all others). Salmeterol (Tocris, 1660) was dissolved in DMSO. The α7 nicotinic acetylcholine receptor antagonist, methyllycaconitine, was dissolved in milliQ water. Forskolin was dissolved in DMSO and used to stimulate cAMP production. The corresponding vehicle control was used for each experiment.

Estrada L.D., Ağaç D, & Farrar J.D. (2016). Sympathetic neural signaling via the β2-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8+ T-cell effector function. European journal of immunology, 46(8), 1948-1958.

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Isometric Tension Measurement in Airway Tissue

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ASM-024 was provided by Asmacure Ltée. ASM-024, methacholine (Methapharm Inc.) and salbutamol (Ventolin, GlaxoSmithKline) were solubilized in appropriate aqueous solution. Formoterol (LKT Laboratories Inc.) and salmeterol (Tocris) were diluted in DMSO. Tissues and cells were exposed to 0.1 to 0.5% DMSO. Isometric tensions were acquired with the data acquisition System MP150 (Biopac Systems) via an isometric force transducer (Harvard apparatus). The data were digitalized and analyzed with AcqKnowledge 3.7.3 software.
This study was carried out in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the Canadian Council on Animal Care (CCAC) regarding acclimation, environmental enrichment, and analgesic and anesthesia procedures. The protocols were approved by the Committee on the Ethics of Animal Experiments of Université Laval. In two experiments, tissues from human donors were obtained after written informed consent in accordance with an Internal Review Board-approved protocol at IUCPQ Research Center (Institut universitaire de cardiologie et de pneumologie de Québec) in Québec, QC (Canada).

Israël-Assayag E., Beaulieu M.J, & Cormier Y. (2015). ASM-024, a Piperazinium Compound, Promotes the In Vitro Relaxation of β2-Adrenoreceptor Desensitized Tracheas. PLoS ONE, 10(3), e0120095.

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