Mole fraction solubility of AHF in three different room temperature ionic liquids (BMMHFP, HMMHFP, and OMMHFP), transcutol-HP, and water was determined by shake flask method [29 (
link),30 (
link)]. The solubility of AHF in these solvents was measured at T = 298.2 K, 303.2 K, 308.2 K, 313.2 K, and 318.2 K under atmospheric pressure. In brief, excess amount of AHF drug was dispersed in each investigated solvents enclosed in screw capped glass flask. Each AHF solution mixture was kept on a
biological shaker (Julabo, Allentown, PA, USA) for shaking at 100 rpm for 72 h to reach equilibrium. After complete saturation of AHF in each solvents, sample was taken from shaker and kept to sediment the drug particles [17 (
link)]. Then, required volume of supernatant samples were withdrawn, filtered and analyzed the AHF after suitable dilution with respective solvents by UV spectrophotometry at 280 nm [26 (
link)]. Each experiments were done in triplicate.
Mole fraction solubilities of AHF (
xe) were calculated with the help of Equation (11) [30 (
link)].
Here,
m1 and
m2 represents the masses of AHF and solvents used, respectively.
M1 and
M2represent the molar masses of AHF and solvents used, respectively.
Anwer M.K., Muqtader M., Iqbal M., Ali R., Almutairy B.K., Alshetaili A., Alshahrani S.M., Aldawsari M.F., Alalaiwe A, & Shakeel F. (2019). Estimating the Solubility, Solution Thermodynamics, and Molecular Interaction of Aliskiren Hemifumarate in Alkylimidazolium Based Ionic Liquids. Molecules, 24(15), 2807.