Human fibrinogen

Manufactured by Prolytix

Human fibrinogen is a plasma protein that plays a critical role in the blood clotting process. It is a soluble glycoprotein that is converted into insoluble fibrin during the coagulation cascade, leading to the formation of a stable blood clot.

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Lab products found in correlation

Control sirna, by Santa Cruz Biotechnology (1 mentions) Poly l lysine solution, by Merck Group (1 mentions) Human fibronectin, by Merck Group (1 mentions) Phorbol 12 myristate 13 acetate pma, by Enzo Life Sciences (1 mentions) Pitstop 2, by Cayman Chemical (1 mentions) Sphero ultra rainbow fluorescent particles, by Spherotech (1 mentions) Human alpha thrombin, by Prolytix (1 mentions) Human factor xa, by Prolytix (1 mentions) Kogenate fs, by Bayer (1 mentions)

Close spelling variants of this product

Fibrinogen (2 citations) Human fibrinogen fragment E (HCI-0150E) (2 citations) Human fibrinogen fragment D (HCI-0150D) (2 citations)

2 protocols using human fibrinogen

Cell Adhesion and Endocytosis Assay

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The following reagents were obtained: human fibronectin (EMD Millipore, Burlington, MA), poly-L-lysine solution (Sigma Life Science, St. Louis, MO), SPHERO Ultra Rainbow fluorescent particles (Spherotech, Inc, Lake Forest, IL), phorbol 12-myristate 13-acetate (PMA) (Enzo Life Sciences, Farmingdale, NY), human fibrinogen (Haematologic Technologies, Essex Junction, VT), and Pitstop 2 (Cayman Chemical, Ann Arbor, MI). Small interfering RNAs (siRNAs) against RUNX1, CAV1, FLOT1, IFITM3 interferon induced transmembrane protein 3, and CLTC clathrin heavy chain, and control siRNAs, were purchased from Santa Cruz Biotechnology Inc, (Dallas, TX). Supplemental Table 1 presents the antibodies and other reagents used.

Del Carpio-Cano F., Mao G., Goldfinger L.E., Wurtzel J., Guan L., Alam M.A., Lee K., Poncz M, & Rao A.K. (2024). Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency. Blood Advances, 8(7), 1699-1714.

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Anticoagulant Assay Development

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All DNA oligos were purchased from Integrated DNA Technologies Inc. Modified RNA oligos were synthesized in house using a Mermade oligo synthesizer followed by HPLC purification. Chemicals were purchased from Sigma without specification. Dabigatran (DAB) and apixaban-COOH (APX) were purchased from AK Scientific Inc. Human alpha thrombin, human factor Xa, and human fibrinogen were purchased from Haematologic Technologies Inc. Recombinant human factor VIII was purified from Kogenate FS (Bayer) and quantified by UV abosorbance. Pooled normal human plasma was purchased from George King Bio-Medical. Human whole blood samples in this work were obtained under Duke IRB protocol (Pro00007265).

Yu H., Kumar S., Frederiksen J.W., Kolyadko V.N., Pitoc G., Layzer J., Yan A., Rempel R., Francis S., Krishnaswamy S, & Sullenger B.A. (2024). Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors. Nature Communications, 15, 3977.

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