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Eclipse proton therapy treatment planning system

Manufactured by Agilent Technologies
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The Eclipse proton therapy treatment planning system is a software tool developed by Agilent Technologies to support the planning and delivery of proton therapy treatments. It provides tools for medical professionals to simulate and optimize proton therapy treatment plans.

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Lab products found in correlation

Pinnacle planning system, by Philips (2 mentions) Linear accelerator, by Agilent Technologies (1 mentions)

3 protocols using eclipse proton therapy treatment planning system

1

Radiation Therapy for Oropharyngeal Cancer

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The standard processes and sequence of treatment for patients with OPC at MD Anderson Cancer Center have been reported elsewhere [47] , [48] , [49] . At least two radiation oncologists examined all patients and target volumes were peer-reviewed for quality assurance purposes. Gross tumor plus margins were prescribed a dose of 66 Gy for small-volume disease and 70 Gy for more advanced disease, and elective regions received 54–63 Gy. For IMPT patients, a relative biological effectiveness (RBE) value of 1.1 was used. Planning for IMPT was done with an Eclipse proton therapy treatment planning system (version 8.9, Varian Medical Systems, Palo Alto, CA, USA). Planning for IMRT was done with a Pinnacle planning system (Philips Medical Systems, Andover, MA, USA). Treatment was delivered with a static gantry approach. IMRT was delivered with a Varian Medical Systems (Palo Alto CA) linear accelerator as 6-MV photons with daily image guidance [50] (link).
Jensen G.L., Blanchard P., Gunn G.B., Garden A.S., David Fuller C., Sturgis E.M., Gillison M.L., Phan J., Morrison W.H., Rosenthal D.I, & Frank S.J. (2017). Prognostic impact of leukocyte counts before and during radiotherapy for oropharyngeal cancer. Clinical and Translational Radiation Oncology, 7, 28-35.
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2

IMPT Treatment for Oropharynx Cancer

Cited 2 times
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The technique, dosimetric details, and planning considerations for treatment of oropharynx cancer with IMPT at the authors’ institution have previously been described in detail [8 (link), 27 –30 (link)]. Briefly, all patients were simulated supine with a non-contrast computed tomography (CT), immobilized using a full length thermoplastic mask, bite block with or without an oral stent and a posterior customized head, neck and shoulder mold. Gross tumor plus margin was typically treated with a total prescribed dose of 66–70 Gy while elective volumes received 54 to 63 Gy, assuming a relative biological effectiveness (RBE) value of 1.1. Dose to the pharyngeal constrictors was minimized by creating an artificial avoidance structure and pushing dose as low as reasonably achievable while maintaining acceptable tumor coverage. The majority of treatments (81.4%) included the bilateral neck. Planning was performed with Eclipse proton therapy treatment planning system (version 8.9, Varian Medical Systems, Palo Alto, California). A 3 beam-arrangement was typically used (a left and right anterior oblique and single posterior beam), with multifield optimization. Daily kilovoltage image guidance was used for all patients, with verification CT simulation scans performed during treatment weeks 1 and 4.
Grant S.R., Hutcheson K.A., Ye R., Garden A.S., Morrison W.H., Rosenthal D.I., Gunn G.B., Fuller C.D., Phan J., Reddy J.P., Moreno A.C., Lewin J.S., Sturgis E.M., Ferrarotto R, & Frank S.J. (2020). Prospective Longitudinal Patient-Reported Outcomes of Swallowing Following Intensity Modulated Proton Therapy for Oropharyngeal Cancer. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 148, 133-139.
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Non-Contrast CT Simulation for Radiotherapy

Cited 1 time
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All patients underwent non contrast-enhanced computed tomography simulation in the immobilization devices as described previously.[21 (link)] At least 2 experienced radiation oncologists examined all patients and reviewed all the contours for quality assurance [21 (link), 22 (link)]. In patients receiving IMRT, the Gross tumor volume plus margins received 70 Gy in 33 fractions. A relative biological effectiveness value of 1.1 was prescribed for IMPT patients. IMPT cases were planned with an Eclipse proton therapy treatment planning system (version 8.9, Varian Medical Systems, Palo Alto, California). IMRT planning was performed with a Pinnacle planning system (Philips Medical Systems, Andover, MA).
A Prospective Longitudinal assessment of MRI Signal Intensity Kinetics of Non-Target Muscles in Patients with Advanced Stage Oropharyngeal Cancer in Relationship to Radiotherapy Dose and Post-Treatment Radiation-Associated Dysphagia: Preliminary findings from a Randomized Trial. (2018). Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 130, 46-55.
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