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78 protocols using transcutol p

1

Formulation Development and Characterization

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MLX was obtained from Hyperchem (China), Transcutol p from Gattefosse Sas (France), Tween 80 and propylene glycol from Chemical Point (Germany), oleic acid oil from Central Drug House(P) LTD (India), methanol from Sigma-Aldrich (Bljika), and hydrochloric acid from ReAgent Chemicals (UK).
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2

Formulation and Characterization of Lipid-based Nanocarriers

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Polyoxyethylene castor oil (Cremophor®EL) was purchased from BASF SE (Ludwigshafen, Germany); highly purified diethylene glycol monoethyl ether (Transcutol®P) was obtained from Gattefossé (Saint-Priest Cedex, France); CRT was purchased from Sigma Aldrich (St. Louis, MO). Lipoid GmBH (Köln, Germany) provided free Phospholipon 90G samples. From S.D. Fine Chemicals Ltd. (Mumbai, India), Tween 20, Tween 80, Span 20, and Span 80 were purchased. Absolute ethanol was purchased from Bengal Chemicals Ltd. (Kolkata, India). Pluronic®F-127 was procured from BASF Corporation (Florham Park, NJ). In this work, all other compounds were of analytical quality, and double distilled water was used.
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3

Topical Formulation Development for CBD/CBG/THCV

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CBD and CBG were obtained from Purisys (GA, USA). THCV was obtained from Open books (NC, USA). N-Methyl-2-pyrrolidone (NMP), Dimethyl sulfoxide (DMSO), Polyethylene glycol (PEG) 400, λ-Carrageenan (plant-mucopolysaccharide) and Oleic acid were purchased from Sigma-Aldrich (USA). Lactic Acid was purchased from Merck (Kenilworth, NJ). Hydroxyethyl cellulose (H.E.C.) was purchased from The Dow Chemical Company (Midland, MI). Isopropyl myristate (IPM), Ethyl Oleate and Polyoxyethylene Oleyl Ether were gifts from Croda (Edison, NJ). Transcutol P, Labrasol and Labrafil were gifts from Gattefossé (France).
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4

Topical Delivery of Botanical Compounds

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HSYA (purity>90%) was provided by Chengdu University (Chengdu, China). Icariin (batch number 489-32-7, purity>98%) was purchased from Shyuanye Biotechnology Co., Ltd (Shanghai, China). Cinnamaldehyde (batch number FY1265VX53J, purity>98%) and 3, 4-dihydroxybenzoic acid (batch number FY17830102, purity>98%) were obtained from Nantong Feiyu Biotechnology Co., Ltd (Nantong, China). Phospholipon 90G, Lipoid 75 andNatipide II were gifts from Lipoid GmbH (Newark, NJ, USA). Soybean lecithin was purchased from TCI America (Boston, MA, USA). Oleic acid (OA), isopropyl myristate (IPM), Tween 20, and Span 80 were purchased from Sigma (Saint Louis, MO, USA). Labrosol ALF, Labrafac 1349, Transcutol P were gifts from GATTEFOSSE (Paramus, NJ, USA). Phosphate buffer saline (PBS), Brij58, ethanol, propylene glycol, acetonitrile, and phosphoric acid were purchased from ACROS Organics (Newark, NJ, USA). All other ingredients and reagents were of analytical grade. Cadaver skin from the posterior torso (female, aged 56) was supplied by the NewYork Firefighters Skin Bank.
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5

Formulation and Evaluation of Enzalutamide Soft Capsules

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ENZ was purchased from MSN Labratories Private Ltd. (Telangana, India). The Xtandi® soft capsule, TPGS and MCT oil were supplied by Boryung Corporation (Seoul, Republic of Korea). Labrafac PG, Peceol, Labrasol, Capryol 90, Transcutol P, and Lauroglycol 90 were obtained from Gattefosse (St. Priest, France). Cremophor EL, Cremophor RH60, and Solutol HS15 were supplied by BASF (Ludwigshafen, Germany). Castor oil, coconut oil, olive oil, sesame oil, sunflower oil, corn oil, soybean oil, cotton seed oil, peanut oil, polysorbate 80, ammonium acetate, acetone, and acetonitrile were purchased from Daejung Co. Ltd. (Siheung, Republic of Korea). Sodium carboxymethyl cellulose was purchased from Duksan Pure Chemical (Ansan, Republic of Korea). All other chemicals used were of analytical grade.
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6

Rosuvastatin-Based Formulation Development

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Pure rosuvastatin was a liberal sample from Sun Pharmaceutical Laboratories, Gurugram. Capmul MCM EP was sympathetically provided by IMCD, Delhi. Tween 20 was purchased from Croda, Transcutol P from Gattefosse, and Pancreatin from Loba Chemie. Rosufine 20 mg tablets of batch no. C-90061 were obtained from a drug store. Other ingredients and reagents utilized in the current research were of analytical grades.
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7

Ibuprofen Formulation Development and Characterization

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Ibuprofen as the model drug was obtained from Baike Pharmaceutical Co. Ltd. (Beijing, China). Excipients such as Labrafac Lipophile WL1349, Labrafil M 1944 CS, Labrasol and Transcutol P were donated by Gattefosse (Shanghai, China). Cremophor RH40 was purchased from Xietai Chemical Co. Ltd. (Shanghai, China). Tween 80, oleic acid, ethanol and propylene glycol were obtained from Meilin Industry and Trade Co. Ltd. (Tianjin, China). Acetonitrile and methanol were HPLC grade and supplied from Kemiou Chemical (Tianjin, China). Other chemicals and solvents were analytical grade.
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8

Formulation Development of LCZ Nanoemulsion

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LCZ was purchased from Macklin Biochemical Co., Ltd. (Shanghai, China); oleic acid was obtained from Tokyo Chemical Industries Co., Ltd. (Tokyo, Japan); propylene glycol dicaprylate (PGD) and castor oil were obtained from Hunan Erkang Pharmaceutical Co., Ltd. (Hunan Province, Changsha, China); Cremophor® RH (RH40), Cremophor® EL35 (EL35) and Kolliphor® HS15 (HS15) were obtained from BASF SE (Ludwigshafen, Germany); Tween 80 was obtained from Jinshan Pharmaceutical Co., Ltd. (Sichuan Province, Meishan, China); polyethylene glycol 400 (PEG400) was purchased from Solarbio Life Science (Beijing, China); Capryol 90, Lauroglycol™ FCC, Lauroglycol and Transcutol® P were received as gifts from Gattefosse (Lyon, France). Methanol and acetonitrile (HPLC grade) were obtained from Merck (Darmstadt, Germany) and Tedia (Fairfield, OH, USA), respectively. Other reagents (analytical grade) were purchased from commercial suppliers.
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9

Finasteride Formulation Analysis Protocol

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Finasteride (99.9%) was purchased from Sequoia Research Products (Pangbourne, UK). Acetonitrile HPLC grade (99.9%), ethanol HPLC grade (EtOH, 99.9%), isopropyl alcohol (IPA, 99.9%), methanol HPLC grade (99.9%), propylene glycol (PG, > 99.0%), phosphate buffer saline (PBS) tablets (10 mM, pH 7.4), Dura Seal™ (Diversified Biotech, USA), Hamilton GASTIGHT® syringes (Hamilton®, Switzerland) and Parafilm M® laboratory film (Bemis® Flexible packaging, USA) were acquired from Fisher Scientific (Loughborough, UK). Sodium thiosulfate pentahydrate (ST, 99.5%) was bought from Acros Organics (New Jersey, USA). Diisopropyl adipate (DPA, > 99.8%) and dimethyl isosorbide (DMI, > 99.8%) were supplied by Croda (Barcelona, Spain). Transcutol® P (TP, > 99.8%) was provided by Gattefosse (France). The 2-octyl cyanoacrylate glue was sourced from Adhezion Biomedical (Wyomissing, USA).
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10

Formulation and Evaluation of Amphotericin B

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Amphotericin B and Sepigel 305® were purchased from Acofarma (Barcelona, Spain). Dimethyl sulfoxide (DMSO) and NaOH were obtained from Sigma-Aldrich (Darmstadt, Germany). TranscutolP® was provided by Gattefossé (Barcelona, Spain). The distilled water used to perform the assays was acquired from a Mili-Q® Plus System (Millipore Co., Burlington, MA, USA).
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