Acetamidophenol

Manufactured by Merck Group

Sourced in United States

Acetamidophenol is a chemical compound used as a raw material in the production of various pharmaceutical products. It is a white crystalline solid with a melting point of approximately 170°C. Acetamidophenol is commonly utilized as a starting material in the synthesis of various active pharmaceutical ingredients.

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4-acetamidophenol (6 citations) 2-acetamidophenol (4 citations) 3-acetamidophenol (4 citations)

2 protocols using acetamidophenol

Characterization of Cytochrome P450 Activity

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Human hepatic microsomes were obtained from Xenotech (Lenexa, KS, USA) and expressed CYP1A2, CYP2C9*1 +OR, CYP2C19 +OR, CYP2E1+OR+ cytochrome b5, CYP2D6*1+OR, and CYP3A4 +OR were purchased from Gentest (Woburn, MA, USA). The designation ‘+OR’ signifies that the preparation contained supplemental, cDNA-expressed cytochrome P450 reductase. Ketoconazole, dextromethorphan, dextrorphan, diclofenac, phenacetin, acetamidophenol, testosterone, 6-β-hydroxy-testosterone, midazolam, quinidine, sulfaphenazole, and nicotinamide adenine dinucleotide phosphate (NADPH) were acquired from Sigma Chemical Co (St Louis, MO, USA). S-(+)-mephenytoin, 4′-hydroxy-mephenytoin, 1′-hydroxy-midazolam, and 4′-hydroxy-diclofenac were obtained from Ultrafine Chemicals (Manchester, UK). 3-N-benzylnirvanol was purchased from Gentest. All other chemicals were the highest grades available.

Martin P., Gillen M., Millson D., Oliver S., Brealey C., Grossbard E.B., Baluom M., Lau D., Sweeny D., Mant T, & Craven K. (2016). Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies. Drugs in R&D, 16(1), 81-92.

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Comprehensive Metabolite Quantification Assay

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Caffeine, allopurinol, paracetamol-glucuronide, paracetamol sulphate, high-purity trifluoroacetic acid, salicyluric acid, N,N-diethyl-paraphenylenediamine (DEPPD), sodium acetate, metaphosphoric acid (MPA) and hydrogen peroxide were supplied by Sigma Chemicals. Paracetamol-mercapturate was supplied by Toronto Research Chemicals. HPLC grade acetonitrile and water was supplied by Burdick & Jackson. Ferrous sulphate was supplied by Labchem. Acetamidophenol, phenylbutyric acid, 2,3 & 2,5 dihydroxy benzoic acid, NADPH, GSH, GSSG and catechol were all obtained from Sigma-Aldrich. Ethyl acetate and diethyl ether were purchased from Merck. N,O Bis(trimethylsilyl)fluoro acetamide (BSTFA) and trimethylchlorosilane (TMCS) were supplied by Sigma Aldrich. 2,4,6-tris-2-(pyridyl)-1,3,5-triazine (TPTZ) and Ferri Chloride (FeCl₃.6H₂O) were also supplied by Sigma Chemicals. Carnitine and acylcarnitine reference standards and deuterated analogues were obtained from Cambridge Isotope Laboratories.

Erasmus E., Steffens F.E., van Reenen M., Vorster B.C, & Reinecke C.J. (2019). Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge. PLoS ONE, 14(5), e0216298.

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