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Zetasizer s90

Manufactured by Malvern Panalytical
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The Zetasizer S90 is a particle size analyzer that measures the size distribution of particles in a sample using the technique of dynamic light scattering. It is capable of measuring particle sizes from 0.3 nanometers to 10 micrometers.

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Lab products found in correlation

Zetasizer nano zs90, by Malvern Panalytical (1 mentions) Prism v7, by GraphPad (1 mentions) 40 μl cuvette, by Malvern Panalytical (1 mentions)

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Zetasizer (953 citations) Zetasizer Nano S90 (147 citations) Malvern Zetasizer Nano S90 (12 citations) Zetasizer S90 series (4 citations) Zetasizer Nano S90 system (3 citations) Zetasizer Nano Series S90 (2 citations) Zetasizer NanoⓇ Model S90 (2 citations)

3 protocols using zetasizer s90

1

Characterization of Lipid Nanoparticles

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Mean PS and poly disperse index (PDI) were analyzed by Zetasizer-S90 (Malvern Instruments, Malvern, UK). An aliquot of lyophilized SLN was resuspended in distilled water, and analysis was performed at a fixed angle of 90°C to the incident light. Data were collected from three measurements, each having 20 runs. Zeta potential (ZP) of the samples was measured in Zetasizer Nano ZS90 (Malvern Instruments) in distilled water with a conductivity of 50 AS/cm at 25°C. ZP was calculated from Smoluchowski equation. All the determinations were performed in triplicate.
Nidhi M., Patro M.N., Kusumvalli S, & Kusumdevi V. (2016). Development of transmucosal patch loaded with anesthetic and analgesic for dental procedures and in vivo evaluation. International Journal of Nanomedicine, 11, 2901-2920.
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2

Particle Size Analysis of Formulations

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A Malvern Zetasizer S90 (Malvern Instruments Ltd., Worcestershire WR14 1XZ, UK) particle size analyzer was used to investigate the particle size of the formulations. The solutions were sonicated and measure the particle size after dilution, its measurement shown in Table 2. Stability of HLPHNs were determined through various parameters such as mean vesicle size, size distribution and zeta potential [30 (link)].
Jangde R., Elhassan G.O., Khute S., Singh D., Singh M., Sahu R.K, & Khan J. (2022). Hesperidin-Loaded Lipid Polymer Hybrid Nanoparticles for Topical Delivery of Bioactive Drugs. Pharmaceuticals, 15(2), 211.
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3

Characterizing OXY-sKLH Conjugate Size

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Analysis was performed using a Zetasizer S90 (Malvern Instruments Inc., Westborough, MA) equipped with a 633 nm laser and an output power in the range of 10–50 mW. The size and diameter of the conjugates were measured under a 173° backscatter. To analyze the aggregation of the conjugate over time, an autopiloted measurement was applied, after manually mixing the sample. Measurements were performed with 75 μL of OXY-sKLH solution in 0.01 M PBS buffer pH 7.2 at a constant temperature of 25 °C using a 40 μL cuvette (Malvern Instruments Inc., Westborough, MA). Data were analyzed using Zetasizer software 7.12 and the raw data were exported to Excel and analyzed with Prism v.7 (Graph pad Software, La Jolla, CA). Analysis of three different OXY-sKLH batches by DLS validated this method (Figure S2). The size distribution of OXY-sKLH was consistent across the three different batches, confirming the reproducibility of the OXY-sKLH conjugation reaction and the DLS as a method to measure the size distribution of these conjugates.
Baruffaldi F., Raleigh M.D., King S.J., Roslawski M.J., Birnbaum A.K., Hassler C., Carroll F.I., Runyon S.P., Winston S., Pentel P.R, & Pravetoni M. (2019). Formulation and Characterization of Conjugate Vaccines to Reduce Opioid Use Disorders Suitable for Pharmaceutical Manufacturing and Clinical Evaluation. Molecular pharmaceutics, 16(6), 2364-2375.
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