Stock solutions of the multikinase inhibitor Sunitinib L-malate (Pfizer, New York, NY, USA) (abbreviated to Sunitinib or SU in the text for simplification) and the glucose metabolism inhibitor (E)-1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one (PFK15 ) were prepared in dimethyl sulfoxide (DMSO; Sigma-Aldrich, USA) at a concentration of 10 mM. The stock solutions were subsequently diluted in an appropriate concentration in ECGM (and finally in test solutions containing 1% DMSO) for the in vitro experiments. Sunitinib was obtained as a gift from a pharmaceutical company (Pfizer Inc., New York, NY, USA). The synthesis and exact structure assignments of PFK15 were performed as described above.
Sunitinib l malate
Manufactured by Pfizer
Sourced in United States
Sunitinib L-malate is a multi-targeted receptor tyrosine kinase inhibitor. It is used as a laboratory research tool for the study of various cellular processes and signaling pathways.
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Lab products found in correlation
2 protocols using sunitinib l malate
1
Preparation of Sunitinib and PFK15 Solutions
2
Preparation of Tyrosine Kinase and Glucose Inhibitors
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Stocks solutions of tyrosine kinase receptors inhibitor sunitinib l-malate (Pfizer, USA) and glucose metabolism inhibitor 3PO, synthetized as described in Murár et al. (2018) (link), were dissolved in dimethyl sulfoxide (DMSO; Sigma-Aldrich, USA) in a concentration of 10 mM. Subsequently, stock solutions were diluted in ECGM to required concentration. All inhibitors were used at concentration, which induced no cytotoxicity.
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