Vemurafenib plx4032

Manufactured by Chemietek

Sourced in United States

Vemurafenib (PLX4032) is a lab equipment product. It is a small-molecule inhibitor that targets the BRAF V600E mutation. The core function of Vemurafenib is to inhibit the BRAF kinase activity.

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Lab products found in correlation

Pd0325901, by Cayman Chemical (1 mentions) Ha ubvs, by R&D Systems (1 mentions) Antibiotic antimycotic, by Thermo Fisher Scientific (1 mentions) Xav939, by Merck Group (1 mentions) Jnj 38877605, by Selleck Chemicals (1 mentions) Su11274, by Merck Group (1 mentions) Hepatocyte growth factor (hgf), by Thermo Fisher Scientific (1 mentions) Everolimus, by LC Laboratories (1 mentions)

Close spelling variants of this product

PLX4032 Vemurafenib

3 protocols using vemurafenib plx4032

Synthesis and Reagents for Ubiquitin Assay

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EOAI3402143 (referred to as G9) was synthesized and provided by Cheminpharma (Branford, CT). Other reagents used in this study were obtained from the following sources: hemagglutinin-tagged ubiquitin vinyl methyl sulfone (HA-UbVS; Boston Biochem); vemurafenib (PLX4032; Chemie Tek); PD 0325901 (Cayman Chemical). All reagents were made up and stored frozen as 10 mM stock solutions.

Potu H., Peterson L.F., Kandarpa M., Pal A., Sun H., Durham A., Harms P.W., Hollenhorst P.C., Eskiocak U., Talpaz M, & Donato N.J. (2017). Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma. Nature Communications, 8, 14449.

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Vemurafenib-resistant Melanoma Cell Culture

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Melanoma cells were cultured in RPMI with 10% fetal bovine serum (FBS) and antibiotic-antimycotic (Invitrogen, Carlsbad, CA, USA). Resistant melanoma cells were cultured in the presence of 1μm vemurafenib/PLX4032 (ChemieTek, Indianapolis, IN, USA).

Titz B., Lomova A., Le A., Hugo W., Kong X., ten Hoeve J., Friedman M., Shi H., Moriceau G., Song C., Hong A., Atefi M., Li R., Komisopoulou E., Ribas A., Lo R.S, & Graeber T.G. (2016). JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma. Cell Discovery, 2, 16028-.

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Molecular Inhibitors and Growth Factor Protocol

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Molecular inhibitors and growth factor: SU11274 (Sigma-Aldrich, CAS 658084-23-2), XAV939 (Sigma-Aldrich, CAS 284028-89-3) JNJ38877605 (Selleck, CAS 943540-75-8) Vemurafenib (PLX4032) (Chemietek, CAS 1029872-54-5), tivantinib (ARQ197) (Chemietek, CAS 905854-02-6) and Everolimus (LC Laboratories, CAS 159351-69-6). All inhibitors were suspended in DMSO and stored in 0.1 mL aliquots at −20 °C. HGF (Peprotech, 100-39).

Etnyre D., Stone A.L., Fong J.T., Jacobs R.J., Uppada S.B., Botting G.M., Rajanna S., Moravec D.N., Shambannagari M.R., Crees Z., Girard J., Bertram C, & Puri N. (2014). Targeting c-Met in melanoma: Mechanism of resistance and efficacy of novel combinatorial inhibitor therapy. Cancer Biology & Therapy, 15(9), 1129-1141.

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