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Afn700

Manufactured by Novartis
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The AFN700 is a laboratory equipment designed for general use in scientific research and analysis. It is a versatile instrument that can perform a variety of tasks. The core function of the AFN700 is to provide accurate and reliable measurements and data for research purposes. Detailed specifications and intended uses are not available.

Automatically generated - may contain errors

Lab products found in correlation

Ouabain, by Merck Group (2 mentions) Mcc950, by Merck Group (2 mentions) Nigericin, by Enzo Life Sciences (2 mentions) Cgp084892, by Novartis (2 mentions) Crt0066101, by Bio-Techne (2 mentions) Baa473, by Novartis (2 mentions) Salmonella typhimurium protein prgl, by Thermo Fisher Scientific (2 mentions) Gramicidin, by Merck Group (2 mentions) Msu crystal, by InvivoGen (1 mentions) D2650, by Merck Group (1 mentions)

2 protocols using afn700

1

Activation of Inflammasome Pathways

Check if the same lab product or an alternative is used in the 5 most similar protocols
Nigericin (Enzo, BML-CA421-005), ouabain (Sigma #O3125), gramicidin (Sigma #G5002), niclosamide (Adipogen #AG-CR1-3643), MSU crystals (InvivoGen # tlrl-msu), DMSO, used as vehicle for compound dilutions (Sigma #D2650), MCC950 (either from Sigma, #5381200001 or synthesized at Novartis), CGP084892 and AFN700 (both synthesized at Novartis), CRT0066101 (Tocris #4975). The pyrin activating compound BAA473 has been previously described [16 (link)]; it was synthesized at Novartis. The NLRC4 activating recombinant Salmonella Typhimurium Protein Prgl was from BioSource #MBS1177087.
Heiser D., Rubert J., Unterreiner A., Maurer C., Kamke M., Bodendorf U., Farady C.J., Roediger B, & Bornancin F. (2021). Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation. PLoS ONE, 16(11), e0248668.
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2

Cellular Activator Compound Assay

Check if the same lab product or an alternative is used in the 5 most similar protocols
Nigericin (Enzo, BML-CA421-005), ouabain (Sigma #O3125), gramicidin (Sigma #G5002), niclosamide (Adipogen #AG-CR1-3643), DMSO, used as vehicle for compound dilutions (Sigma #D2650), MCC950 (either from Sigma, #5381200001 or synthesized at Novartis), CGP084892 and AFN700 (both synthesized at Novartis), CRT0066101 (Tocris #4975). The pyrin activating compound BAA473 has been previously described (16) ; it was synthesized at Novartis. The NLRC4 activating recombinant Salmonella Typhimurium Protein Prgl was from BioSource #MBS1177087.
Heiser D., Rubert J., Unterreiner A., Maurer C., Kamke M., Bodendorf U., Farady C.J., Roediger B., & Bornancin F. (2021). Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation.
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