Brain Aβ was also measured using [18F]flutemetamol PET22 (link) in a subpopulation (n = 134). We conducted PET/CT scanning between 2013 and 2015 using the same type of Philips (Best, the Netherlands) Gemini TF 16 scanner at 2 different sites. Average uptake was estimated from PET sum images from 90 to 110 minutes after injection. The images were analyzed with the NeuroMarQ software provided by GE Healthcare (Cleveland, OH). A volume of interest template was applied for 9 bilateral regions (prefrontal, parietal, lateral temporal, medial temporal, sensorimotor, occipital, anterior cingulate, and posterior cingulate/precuneus), combined in a global neocortical composite signal.23 (link) The standardized uptake value ratio (SUVR) was the global composite tracer uptake, normalized for the mean uptake in the cerebellar cortex.
Gemini tf 16 scanner
Manufactured by Philips
Sourced in Netherlands
The Gemini TF 16 scanner is a high-performance laboratory equipment designed for advanced imaging applications. It incorporates dual-energy X-ray technology to provide detailed and precise scanning capabilities. The core function of this scanner is to capture and process comprehensive imaging data to support various scientific research and analysis requirements.
Automatically generated - may contain errors
Lab products found in correlation
3 protocols using gemini tf 16 scanner
1
Measuring Brain Amyloid-Beta with PET Imaging
2
Standardized [18F]FDG PET/CT Imaging Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All patients underwent an [18F]FDG PET/CT investigation before treatment. Scans were performed 60 ± 15 min after IV injection of [18F]FDG with a mean activity of 364 ± 75 MBq. The acquisition was performed using a 16-slice multidetector scanner (Gemini TF 16 Scanner, Philips, Healthcare Medical Systems, Inc, Cleveland, OH) using the following parameters: 100–250 mAs, 120 kV, slice thickness 5 mm. The PET scan was performed in 3D mode with an acquisition time of 1.30 min per bed position (eight-twelve bed positions) covering the same field as the CT scan. The obtained images were reconstructed using the ordered subset expectation maximization (OSEM) iterative algorithm. All studies were performed on the same scanner to provide consistent reconstruction algorithms.
3
Multimodal Neuroimaging of Neurodegenerative Disorders
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All subjects underwent longitudinal 18F-RO948 PET on a GE Discovery scanner and structural MRI on a Siemens Prisma 3 T scanner. In addition, 85 non-demented individuals also had longitudinal 18F-flutemetamol PET scans on a Philips Gemini TF 16 scanner.
18F-RO948 PET images were acquired 70–90 min after injection of 370 MBq 18F-RO948, reconstructed using VPFX-S (ordered subset expectation maximization combined with corrections for time-of-flight and point spread function) with six iterations and 17 subsets with 3 mm smoothing, a standard Z filter and 25.6-cm field of view (256 × 256 matrix).
Structural T1-weighted images were acquired using a magnetization-prepared rapid gradient echo (MPRAGE) sequence using the following parameters: 178 slices, repetition time: 1950 ms, echo time: 3.4 ms, inversion time: 900 ms, flip angle: 9°, 1 mm isotropic voxels. In addition, fluid-attenuated inversion recovery (FLAIR) images were also acquired at baseline with the following parameters: 176 slices, repetition time: 5000 ms, echo time: 393 ms, inversion time: 1800 ms, 1 mm isotropic voxels.
Finally, 18F-flutemetamol PET images were acquired 90 to 110 min after injection of 185 MBq 18F-flutemetamol and reconstructed into 4 × 5 frames using the line-of-response row-action maximum-likelihood algorithm.
18F-RO948 PET images were acquired 70–90 min after injection of 370 MBq 18F-RO948, reconstructed using VPFX-S (ordered subset expectation maximization combined with corrections for time-of-flight and point spread function) with six iterations and 17 subsets with 3 mm smoothing, a standard Z filter and 25.6-cm field of view (256 × 256 matrix).
Structural T1-weighted images were acquired using a magnetization-prepared rapid gradient echo (MPRAGE) sequence using the following parameters: 178 slices, repetition time: 1950 ms, echo time: 3.4 ms, inversion time: 900 ms, flip angle: 9°, 1 mm isotropic voxels. In addition, fluid-attenuated inversion recovery (FLAIR) images were also acquired at baseline with the following parameters: 176 slices, repetition time: 5000 ms, echo time: 393 ms, inversion time: 1800 ms, 1 mm isotropic voxels.
Finally, 18F-flutemetamol PET images were acquired 90 to 110 min after injection of 185 MBq 18F-flutemetamol and reconstructed into 4 × 5 frames using the line-of-response row-action maximum-likelihood algorithm.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!