All examinations at the Positron Emission Centre of Aarhus University Hospital were performed with an integrated PET/computed tomography (CT) system (Siemens Biograph True point 64 PET/CT, Siemens, Erlangen, Germany), one bed position spanning 21 cm. The pigs were anaesthetized with propofol, intubated (for mechanical ventilation), and placed in dorsal recumbence as described by Alstrup and Winterdahl [8 ]. Initially, a scout view was obtained to secure body coverage from snout to tail.
Biograph true point 64 pet ct
Manufactured by Siemens
Sourced in Germany, United States
The Biograph True Point 64 PET/CT is a medical imaging system that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to provide high-quality images for clinical diagnosis and treatment planning.
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4 protocols using biograph true point 64 pet ct
1
PET/CT Imaging of Anesthetized Pigs
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Quantitative PET/CT Imaging of FDG Uptake
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Six-hour fasting blood sugar levels in all patients were measured before PET. If blood sugar was >200 mg/dL before the study, the PET was rescheduled. After 370 MBq of 18F-FDG was administered intravenously, we employed a lutetium-oxyorthosilicate-detector-equipped and 64-slice-CT-scanner equipped Biograph TruePoint 64 PET/CT scanner (Siemens, Knoxville, TN, USA) for image acquisition. To correct for PET attenuation, a low-dose unenhanced CT scan was executed, and, with regard to the parameters employed in this process, the tube voltage, current, rotation time, and pitch were set to 120 kV, 50 mAs, 0.5 s per rotation, and 0.8, respectively. True whole-body PET images were then taken from the vertex of the skull to the feet. The regions of interest (ROIs) on simultaneously displayed sagittal, coronal, and axial tomography images were determined to be those covering lesions exhibiting 18F-FDG uptake. An experienced nuclear medicine physician (Kuo-Wei Ho) delineated the ROIs that were used to calculate body-weight-normalized SUVs, and, in each ROI, SUVmax was assigned to the voxel with the greatest FDG uptake. We derived the NTR as the SUV-N-to-SUV-T ratio [25 (link)].
3
Quantitative FDG PET/CT Analysis
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All patients fasted for >6 h before undergoing PET/CT, and the blood glucose level was <180 mg/dl. Images from the mid skull to the upper thigh were taken approximately 60 min after intravenous administration of 370 MBq F-18 FDG. The Discovery™ PET/CT tomograph (GE Healthcare, Milwaukee, WI, USA) and Biograph Truepoint 64™ PET/CT (Siemens Healthineers) were used. All PET images were reconstructed using an iterative algorithm and attenuation correction with CT images.
Two nuclear medicine specialists independently reviewed the images. For semiquantitative analysis, all images were reviewed on a designated workstation. SUVmax was measured within a designated region of interest (ROI) and defined as the highest SUV of pixel. MTV, which was determined by measuring the volume of the lesion above the 3.0 SUV value and the TLG was determined by the MTV × SUVmean. MTV and TLG were calculated as the summation of individual MTV and TLG within the field of image.
Two nuclear medicine specialists independently reviewed the images. For semiquantitative analysis, all images were reviewed on a designated workstation. SUVmax was measured within a designated region of interest (ROI) and defined as the highest SUV of pixel. MTV, which was determined by measuring the volume of the lesion above the 3.0 SUV value and the TLG was determined by the MTV × SUVmean. MTV and TLG were calculated as the summation of individual MTV and TLG within the field of image.
4
Dynamic [18F]PI-2620 PET Brain Imaging
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[18F]PI-2620 PET imaging was performed in a full dynamic setting (0–60 min p.i.) on different scanners (Munich: Siemens Biograph True point 64 PET/CT & Siemens mCT, Siemens, Erlangen, Germany; New Haven: Siemens ECAT EXACT HR+, Siemens, Erlangen, Germany; Melbourne: Philips Gemini TF 64 PET/CT, Eindhoven, The Netherlands) at three specialized neuroimaging sites using the established standard scan protocol of each center for brain PET imaging. The injected bolus dose was 217 ± 53 MBq (range: 178–334 MBq). Details on all scanners, as well as acquisition and reconstruction parameter are provided in the Supplement of our previous study.32 (link)
Dynamic emission recordings were framed into 6x30s, 4x60s, 4x120s and 9x300s. Data from Hofmann phantoms were used to obtain scanner specific filter functions which were then consequently used to generate images with a similar resolution (FWHM: 9 × 9 × 10 mm), following the ADNI image harmonization procedure.40 (link)
All dynamic datasets were visually inspected for motion (∼5 mm threshold) and automatically corrected for motion of more than 5 mm using the motion correction tool in PMOD (V3.9 PMOD technologies Basel, Switzerland). In brief, this tool performs coregistration of individual PET frames to each other to guarantee a precise regional overlap of all frames in a multi-frame dataset.
Dynamic emission recordings were framed into 6x30s, 4x60s, 4x120s and 9x300s. Data from Hofmann phantoms were used to obtain scanner specific filter functions which were then consequently used to generate images with a similar resolution (FWHM: 9 × 9 × 10 mm), following the ADNI image harmonization procedure.40 (link)
All dynamic datasets were visually inspected for motion (∼5 mm threshold) and automatically corrected for motion of more than 5 mm using the motion correction tool in PMOD (V3.9 PMOD technologies Basel, Switzerland). In brief, this tool performs coregistration of individual PET frames to each other to guarantee a precise regional overlap of all frames in a multi-frame dataset.
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