2 iodobenzonitrile

Manufactured by ABCR

2-Iodobenzonitrile is a chemical compound with the molecular formula C7H4IN. It is a solid crystalline substance at room temperature. 2-Iodobenzonitrile is commonly used as a reagent in organic synthesis and chemical research.

Automatically generated - may contain errors

Lab products found in correlation

3 protocols using 2 iodobenzonitrile

Synthesis of Indolo[2,3-d]benzazepinone Derivatives

Check if the same lab product or an alternative is used in the 5 most similar protocols

2-Iodobenzonitrile, ethyl-1H-indole-carboxylate and 5-bromo-ethyl-1H-indole-carboxylate were purchased from ABCR. Borane solution (1M in THF), absolute DMF, dimethylaminopyridine, di-tert-butyl-dicarbonate, absolute acetonitrile, palladium(II) acetate, sodium bicarbonate, basic aluminuim oxide, 2-acetylpyridine and 2-formylpyridine were bought from Fisher/Acros Organics. Ethoxy-methylchloride was obtained form TCI. Sodium hydride, phosphorus(V) sulfide, celite, hydrazine monohydrate and methyl iodide were purchased from Sigma Aldrich, while lithium hydroxide monohydrate and triphenylphosphine were from Alfa Aesar. 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide-hydrochloride was purchased from IRIS biotech. Silver(I) carbonate was purchased from Merck. 2-Iodobenzylamine was prepared by a known method.^{26 (link)} The unsubstituted indolo[2,3-d]benzazepinone (A) was prepared by following published protocols.^{18 (link)–20} The 11-bromo-substituted B was prepared using reported precedures,^{18 (link)–20} with some modifications, a detailed description of the synthesis of B is given in the Supplementary Information file.

Bacher F., Wittmann C., Nové M., Spengler G., Marć M.A., Enyedy E.A., Darvasiova D., Rapta P., Reiner T, & Arion V.B. (2019). Novel latonduine derived proligands and their copper(II) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and in vitro cancer selectivity. Dalton transactions (Cambridge, England : 2003), 48(28), 10464-10478.

+ Open protocol

+ Expand

Synthesis of Diverse Pyridyl-Substituted Indole Scaffolds

Check if the same lab product or an alternative is used in the 5 most similar protocols

5-Nitro-1H-indole-3-carboxaldehyde,
2-iodobenzonitrile, and silver(I) carbonate were purchased from abcr.
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI·HCl)
and trifluoroacetic acid were purchased from IRIS biotech, while palladium
(10%) on activated charcoal, tert-butyl dicarbonate
(Boc₂O), palladium(II) acetate, 4-(dimethylamino)pyridine
(DMAP), sodium chlorite, and sulfamic acid were obtained from Sigma-Aldrich.
2-Formylpyridine, absolute dimethylformamide (DMF), tetra-n-butylammonium fluoride (TBAF), 4-toluenesulfonyl chloride, triethylamine,
sodium bicarbonate, magnesium sulfate, and borane solution (1 M in
THF) were bought from Fisher/Acros Organics. Triphenylphosphine, sodium
bicarbonate, and celite were purchased from Alfa Aesar. 2-Iodobenzeneethylamine
was prepared by using a literature protolol.^{28 (link)}Synthesis of the main organic scaffolds b₁–h₃ is described in detail in the Supporting Information. ¹H NMR spectra of intermediate species b₁, b₂, c₁–c₃, d₁–d₃, e₁–e₃, f₁–f₃, g₁–g₃, h₁, and h₂ are shown in Figures S36–S54.

Kuznetcova I., Ostojić M., Gligorijević N., Aranđelović S, & Arion V.B. (2022). Enriching Chemical Space of Bioactive Scaffolds by New Ring Systems: Benzazocines and Their Metal Complexes as Potential Anticancer Drugs. Inorganic Chemistry, 61(50), 20445-20460.

+ Open protocol

+ Expand

Synthesis of Indolo-Benzazepin Derivatives

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

2-Iodobenzonitrile,
indole-3-carboxaldehyde, and 5-bromoindole-3-carboxaldehyde
were purchased from ABCR. Borane solution (1 M in THF), absolute DMF,
4-dimethylaminopyridine (DMAP), di-tert-butyl-dicarbonate
(Boc₂O), absolute acetonitrile (ACN), palladium(II) acetate,
sodium bicarbonate, tetrabutylammoinium fluoride (TBAF), basic aluminium
oxide, and 2-formylpyridine were bought from Fisher/Acros Organics.
2-Acetylpyridine was obtained from TCI. Sodium hydride (NaH, 60% dispersion
in mineral oil), copper(II) chloride dihydrate, p-toluenesulfonyl chloride, phosphorus pentasulfide, methanol, DCM,
THF, ethyl acetate (EtOAc), hexane, celite, and hydrazine monohydrate
were purchased from Sigma-Aldrich. EDCI·HCl was obtained from
IRIS biotech, while silver(I) carbonate was purchased from Merck.
2-Iodobenzylamine was prepared by a known method.^{65 (link)} The proligands HL⁵–HL¹¹ and the corresponding
complexes 5–11 were prepared as reported previously,^{33 (link),39 (link)} while 5,12-dihydroindolo[3,2-d]benzazepin-7(6H)-one was synthesized by following a literature protocol.^{37 (link)} Absolute hydrazine was preabsoluted over sodium
hydroxide.

Kuznetcova I., Bacher F., Alfadul S.M., Tham M.J., Ang W.H., Babak M.V., Rapta P, & Arion V.B. (2022). Elucidation of Structure–Activity Relationships in Indolobenzazepine-Derived Ligands and Their Copper(II) Complexes: the Role of Key Structural Components and Insight into the Mechanism of Action. Inorganic Chemistry, 61(26), 10167-10181.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!