Cardiophase high sensitivity c reactive protein immunoassay

Biomarkers measured in this study at baseline included ST2 (fibrosis); GDF-15 (apoptosis); NT-proBNP (N-terminal pro-B-type natriuretic peptide; myocyte stretch); cTnI (cardiac troponin I; myocardial injury); hsCRP and IL-6 (interleukin-6; inflammation); cystatin C (renal dysfunction); and D-dimer (thrombosis).^{13 (link)–18 (link)} GDF-15, cystatin C, and IL-6 were measured using a Quantikine Human Immunoassay (R&D Systems, Minneapolis, MN). ST2 was measured using the Presage Assay (Critical Diagnostics, San Diego, CA). C-Reactive Protein (CRP) was measured using the CardioPhase High Sensitivity C-Reactive Protein Immunoassay (Siemens Medical Solutions Diagnostics, Tarrytown, NY). Troponin was measured using the Advia Centaur TnI-Ultra Assay (Siemens Medical Solutions Diagnostics). NT-proBNP was measured by the Roche E Modular assay (Roche Diagnostics Corporation, Indianapolis, IN). D-dimer was measured using the Zymutest D-Dimer ELISA (Aniara, West Chester, OH). Details on sensitivity, range, and coefficients of variation have been published previously.^{2 (link)}