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72 protocols using brilliance ict 256

1

Triglyceride-Glucose Index and Coronary Artery Calcium

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The TyG index was determined using ln (triglycerides [mg/dL] ×glucose [mg/dL]/2). All subjects were categorized into four groups based on the quartiles of the TyG index level. CAC scores were calculated using the Agatston method [14 (link)]. CAC progression was defined as a diference ≥ 2.5 between the square roots (√) of the baseline and follow-up CACSs (Δ√transformed CACS) considering inter-scan variability [15 (link)]. Annualized Δ√transformed CACS was defined as Δ√transformed CACS divided by the inter-scan period.
Multi-detector CT scanners used to assess CAC had at least 16 slices (Philips Brilliance 256 iCT, and Philips Brilliance 40-channel multi-detector CT, GE 64-slice Lightspeed, Siemens 16-slice Sensation). All centers performed standard prospective or retrospective methods.
Diabetes was defined as either a fasting glucose level ≥ 126 mg/dL, HbA1C level ≥ 6.5%, a referral diagnosis of diabetes, or use of anti-diabetic treatment [16 (link)].
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2

Standardized CT Scan Protocol for Renal Imaging

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During the study period, all CT scans were performed using either a Brilliance 64-slice spiral CT or a Brilliance 256-ICT (Philips, Best, The Netherlands). The scanning parameters were: tube voltage of 120 kV, tube current of 250 to 300 mA, thread pitch of 1.0, thickness of scanning layer of 5 mm, and thickness of reconstruction layer of 1 mm. The scanning range was from the upper margin of the liver to the bilateral anterior superior iliac spine, totally covering the kidneys. Enhanced scan was performed using an antecubital venous injection of Iobitridol (350 mgI/mL; a nonionic contrast agent; Guerbet, Roissy-Charles-de-Gaulle, France) with a total dose of 80 to 100 mL and injection rate of 3.5 ml/s. After injection of the contrast agent, the corticomedullary phase scan was carried out at 30 to 40 ms, the parenchymal phase at 60 to 70 ms, and the excretory phase at 120 to 180 ms. The original data were uploaded to the postprocessing workstation (IntelliSpace Portal, Philips, Best, The Netherlands) for image analysis. The radiologists were blind to the clinical pathological data when reviewing the images.
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3

Assessing Coronary Artery Calcium Progression

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Multi-detector CT scanners used to assess CAC had at least 16 slices (Siemens 16-slice Sensation, Philips Brilliance 256 iCT, Philips Brilliance 40 channel multi-detector CT, and GE 64-slice Lightspeed). CAC scores were calculated using the Agatston method [18 (link)]. The square root transformed difference was calculated [√CAC score (follow-up)—√CAC score (baseline)], and CAC progression was defined as a square root transformed difference of >2.5 to minimize the effect of interscan variability [19 (link), 20 (link)]. For participants with more than two CT scans, the square root transformed difference was calculated for each follow-up CT scan, and the earliest follow-up scan with demonstrated CAC progression was included in the analysis. The CAC progression rate was calculated as the annualized difference between the square root of the baseline and last follow-up CAC scores.
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4

Cardiac CT Imaging Protocol

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Philips Brilliance 256 iCT was used for scanning. Breathing training was performed before scanning, diagnostic processes, and possible adverse effects of contrast agent. The scanning area of prospective ECG-gating was from 1 cm below the trachea carina to 1 cm below the left diaphragm. The direction was from head to feet. The injecting scheme was: 40 ml normal saline was injected after 50–60 ml contrast agent (4.5–5.5 ml/s); thresholding method; target area was descending aorta; and the trigger CT value of automatic scanning was 100 HU. Parameters of group A were 100 kV and 200–250 mAs. Parameters of group B and C were 120 kV and 200–250 mAs. Idose3 was used for iterative reconstruction. The collimator width was 128×0.625 mm. The rotational speed of the X-ray tube was 0.27 s/round. The prior time phase center of iterative reconstruction was 75%. Time window width was 10%.
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5

Spiral CT-guided Lung Nodule Biopsy

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A 256-slice spiral CT scan (Brilliance 256 iCT, Philips, The Netherlands) was used. Patients were classified into Groups A and B based upon different scanning parameters: 80 kV for Group A (low voltage) and 120 kV for Group B. The tube current was modulated automatically in both groups. The image reconstruction layer thickness was 1.5 mm, and the layer spacing was 1 mm, using a soft-tissue algorithm. The lung window had a width of 1,600 HU and a level of 600 HU, and the mediastinal window had a width of 250 HU and a level of 40 HU. The window level and width were adjusted to remove metal artifacts and identify the location of the needle puncture. The scan range was 5 cm surrounding the pulmonary nodules (Figure 1). The needle (PAJUNK, German) used was 20-gauge (20G), and the effective length was 12 cm.
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6

Coronary Artery Calcification Assessment via MSCT

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The patients underwent coronary artery calcification testing using a >16-slice multi-sensor CT (MSCT) scanner (GE 64-slice Lightspeed, Siemens 16-slice Sensation, Philips Brilliance 256 iCT, or Philips Brilliance 40-channel multi-detector). Horiguchi et al. found a high agreement between 16-slice MSCT scanner and EBCT in CACS [15] . A study by Kopp et al. showed that using MSCT scanners resulted in less inter-scan variability compared to using EBCT [16] . CACS was calculated using the Agatston scoring system [17] . To obtain an accurate score, observers performed a modification procedure to remove calcium located outside the coronary arteries. CACS was categorized into four groups: very low risk, 0; low risk, 1e100; moderate risk, 101e400; and high risk, !401. Also, prior studies have demonstrated excellent inter-scanning reproducibility for Agatston, mass, and volume score [18] .
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7

CT-Based Psoas Muscle Thickness Assessment

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For all examinations, commercially available clinical CT imaging systems (Philips Brilliance 64 or Philips Brilliance 256 iCT; both Philips Healthcare, Best, the Netherlands) were used. We analyzed the transversal psoas muscle thickness (TPMT) as previously described in cross-sectional images on the level of the umbilicus (5 (link)). Briefly, the maximum transverse diameter of the right psoas muscle was measured in millimeters and normalized for height (in meters) to calculate TPMT/height (see Figure 1b, Supplementary Digital Content 1, http://links.lww.com/CTG/A22). We chose the umbilicus because it is easy to identify in CT and it was used as a landmark in the aforementioned description of the method (5 (link)). The umbilicus in this cohort was located at the level of L4 in 70%, L5 in 20%, and L3 in 10% of patients (data not shown). The median time between CT and TIPS was 542 ± 88 days. The assessments were performed by 2 hepatologists (M.P. and C.C.) who had been trained by an expert radiologist (C.M.).
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8

Imaging-Based Diagnosis and Evaluation of HCC

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The diagnosis of HCC was done with contrast-enhanced imaging (multidetector row CT or magnetic resonance imaging (MRI)). Commercially available clinical 3.0 Tesla MR imaging system (Ingenia 3.0 T; Philips Healthcare, Best, Netherlands) or a 1.5 Tesla MR imaging system (Ingenia 1.5 T; Philips Healthcare, Best, Netherlands) or CT imaging systems (Philips Brilliance 64 or Philips Brilliance 256 iCT, both Philips Healthcare, Best, the Netherlands) were used. HCC was diagnosed only if typical imaging features were detected [11 ]. Follow-up imaging was also performed by contrast-enhanced imaging (CT or MRI). Response to treatment was determined by contrast-enhanced imaging at three months (Fig 1b). Response to local ablative therapy was defined as lack of contrast enhancement in the lesion of interest as sign of vital tumor mass. Non-response was defined as detection of vital tumor mass. Additionally, response was also classified according to RECIST criteria [12 (link)]. Response was defined as RECIST complete remission (CR), while no response was defined as RECIST stable disease (SD) or progressive disease (PD). Follow up imaging was then performed 90 days after local ablative therapy and further recorded until the end of study, death or occurrence of Non-TL.
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9

Abdominal CT Imaging Protocols

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CT examinations of the abdomen were performed on the following CT scanners: Siemens Definition Flash, Siemens Somatom Definition AS 40, Siemens Sensation 40, and Siemens Emotion 16 (256 rows, 40 rows, 40 rows, and 16 rows, Siemens Healthcare, Germany); Philips Brilliance iCT 256 (256 rows, Philips Healthcare, Hamburg, Germany). The CT scan protocol consisted of, at least, a portal-venous phase. Optionally, non-enhanced, arterial and late phases were performed. Accurate timing of the optional arterial phase was ensured by automated bolus tracking in the suprarenal aorta. The portal-venous phase was obtained with a delay of 60 s. Optionally, with an additional delay of 180 s, a late phase was acquired.
All images were reconstructed using a soft tissue convolution Kernel (either B30f, B30s, I30f, or B41s). Slice thicknesses of the reconstructed images were 2 mm in 1 patient, 3 mm in 16 patients, 4 mm in 1 patient, and 5 mm in 6 patients.
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10

CT Imaging Protocol for Acute Ischemic Stroke

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CT was performed on a range of scanners from different vendors including Siemens Somatom X.cite, Somatom Definition Flash, Somatom Definition AS+, and Somatom Definition Edge Plus (Siemens, Erlangen, Germany), as well as GE Revolution (General Electric, Boston, MA, USA) and Philips Brilliance iCT 256 (Philips, Amsterdam, The Netherlands). The three-phase CT clinical protocol consists of NCCT, an arterial phase measured with CTA and CTV after intravenous contrast agent injection. Due to the different scanner types and acute setting of AIS, the CTV was timed with a mean delay of 70 ± 28 s after the CTA. A fixed tube voltage of 120 kV for both the unenhanced and venous phases was used.
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