The diagnosis of HCC was done with contrast-enhanced imaging (multidetector row CT or magnetic resonance imaging (MRI)). Commercially available clinical 3.0 Tesla MR imaging system (
Ingenia 3.0 T; Philips Healthcare, Best, Netherlands) or a 1.5 Tesla MR imaging system (
Ingenia 1.5 T; Philips Healthcare, Best, Netherlands) or CT imaging systems (Philips Brilliance 64 or
Philips Brilliance 256 iCT, both Philips Healthcare, Best, the Netherlands) were used. HCC was diagnosed only if typical imaging features were detected [11 ]. Follow-up imaging was also performed by contrast-enhanced imaging (CT or MRI). Response to treatment was determined by contrast-enhanced imaging at three months (
Fig 1b). Response to local ablative therapy was defined as lack of contrast enhancement in the lesion of interest as sign of vital tumor mass. Non-response was defined as detection of vital tumor mass. Additionally, response was also classified according to RECIST criteria [12 (
link)]. Response was defined as RECIST complete remission (CR), while no response was defined as RECIST stable disease (SD) or progressive disease (PD). Follow up imaging was then performed 90 days after local ablative therapy and further recorded until the end of study, death or occurrence of Non-TL.
Praktiknjo M., Krabbe V., Pohlmann A., Sampels M., Jansen C., Meyer C., Strassburg C.P., Trebicka J, & Gonzalez Carmona M.A. (2018). Evolution of nodule stiffness might predict response to local ablative therapy: A series of patients with hepatocellular carcinoma. PLoS ONE, 13(2), e0192897.