Melting points were recorded on an advanced melting point apparatus, SMP30, Stuart (Bibby Scientific, London, UK). Microanalytical data were gathered with a Vario Elementar apparatus (Shimadzu-Japan). Elemental analyses of all compounds were within ± 0.4% of the theoretical values. The IR spectra (KBr) were recorded on a Perkin Elmer 1650 spectrometer (USA). 1H and 13C NMR spectra (500 MHz for 1H and 125 MHz for 13C NMR) were recorded on JEOL ECA-500 (Shimadzu) instruments.
Chemical shifts were expressed in ppm relative to SiMe4 as an internal standard in DMSO-d6 or (CDCl3) as a solvent. Mass spectra were recorded on a 70 eV Finnigan SSQ 7000 spectrometer (Thermo-Instrument System Incorporation, USA). Follow up of the reaction and the purity of the compounds was checked on aluminum plates coated with silica gel (Merck, Germany) on Microwave Advanced Flexible Synthesis Platform 1900 W (flexiWAVE—Milestone, Italy), producing continuous irradiation and equipped with a simultaneous external air-cooling system. Chemicals and solvents (Analar ≥ 99%) were purchased from Sigma-Aldrich (USA).
Chemical shifts were expressed in ppm relative to SiMe4 as an internal standard in DMSO-d6 or (CDCl3) as a solvent. Mass spectra were recorded on a 70 eV Finnigan SSQ 7000 spectrometer (Thermo-Instrument System Incorporation, USA). Follow up of the reaction and the purity of the compounds was checked on aluminum plates coated with silica gel (Merck, Germany) on Microwave Advanced Flexible Synthesis Platform 1900 W (flexiWAVE—Milestone, Italy), producing continuous irradiation and equipped with a simultaneous external air-cooling system. Chemicals and solvents (Analar ≥ 99%) were purchased from Sigma-Aldrich (USA).