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Zoledronic acid zometa

Manufactured by Novartis
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Zoledronic acid (Zometa) is a bisphosphonate compound used in the treatment of various medical conditions. It is primarily used to prevent and treat osteoporosis, as well as to manage hypercalcemia of malignancy and skeletal-related events in cancer patients.

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Lab products found in correlation

Anti nox4, by Abcam (2 mentions) Anti tgf β antibody clone 1d11.16.8 1d11, by BioXCell (2 mentions) Mouse igg1 isotype control mopc 21 unknown specificity, by BioXCell (2 mentions) Anti dnp, by Merck Group (2 mentions) Anti cys no antibody, by Merck Group (2 mentions) Anti calstabin antibody, by Santa Cruz Biotechnology (2 mentions) Fura red, by Thermo Fisher Scientific (2 mentions) Recombinant human tgf β1, by R&D Systems (2 mentions) Anti tubulin, by Merck Group (2 mentions) Fluo 4 am, by Thermo Fisher Scientific (2 mentions) Anti gapdh, by Merck Group (2 mentions) Anti smad3, by Abcam (2 mentions) Anti p smad3, by Abcam (2 mentions) Anti ryr, by Thermo Fisher Scientific (2 mentions)

Close spelling variants of this product

Zoledronic acid Zometa

2 protocols using zoledronic acid zometa

1

Investigating TGF-β1 Signaling Pathways

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Recombinant human TGF-β1 was purchased from R&D Systems. SD-208 was obtained from Epichem Pty Ltd (Bentley, WA). Zoledronic acid (Zometa) was obtained from Novartis (Cambridge, MA). Rycal S107 (S107-HCl, FW 245.77) was synthesized as previously described17 (link),37 (link). Anti-TGF-β antibody clone 1D11.16.8 (1D11) and mouse IgG1 isotype control (MOPC-21; unknown specificity) were obtained from BioXCell (West Lebanon, NH). Nox4 inhibitor (GKT137831) was obtained from Ark Pharm, Inc. (Libertyville, IL). Antibodies: Anti-RyR (Affinity Bioreagents, cat. MA3-916, Golden, CO; 1:2,000), anti-Cys NO antibody (Sigma, cat. N0409, St. Louis, MO; 1:2,000), anti-calstabin antibody (Santa Cruz Biotechnology, cat. sc-6173, Santa Cruz, CA; 1:2,500), anti-DNP (Oxyblot, Millipore, Darmstadt, Germany; 1:250), anti-pSMAD3 (Abcam, cat. ab40854, Cambridge, UK; 1:1000), anti-SMAD3 (Abcam, cat. 52903, Cambridge, UK; 1:1000), anti-Nox4 (Abcam, cat. 109225, Cambridge, UK; 1:1000), anti-GAPDH (Sigma, cat. G8795, St. Louis, MO; 1:500) and anti-tubulin (Sigma, cat. 8203, St. Louis, MO; 1:500 each). Fluo-4 AM and Fura-red were obtained from Invitrogen/Molecular probes (cat. F-14201 and cat. F-3020, Eugene, OR).
Waning D.L., Mohammad K.S., Reiken S., Xie W., Andersson D.C., John S., Chiechi A., Wright L.E., Umanskaya A., Niewolna M., Trivedi T., Charkhzarrin S., Khatiwada P., Wronska A., Haynes A., Benassi M.S., Witzmann F.A., Zhen G., Wang X., Cao X., Roodman G.D., Marks A.R, & Guise T.A. (2015). Excess TGF-β mediates muscle weakness associated with bone metastases in mice. Nature medicine, 21(11), 1262-1271.
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2

Investigating TGF-β1 Signaling Pathways

Check if the same lab product or an alternative is used in the 5 most similar protocols
Recombinant human TGF-β1 was purchased from R&D Systems. SD-208 was obtained from Epichem Pty Ltd (Bentley, WA). Zoledronic acid (Zometa) was obtained from Novartis (Cambridge, MA). Rycal S107 (S107-HCl, FW 245.77) was synthesized as previously described17 (link),37 (link). Anti-TGF-β antibody clone 1D11.16.8 (1D11) and mouse IgG1 isotype control (MOPC-21; unknown specificity) were obtained from BioXCell (West Lebanon, NH). Nox4 inhibitor (GKT137831) was obtained from Ark Pharm, Inc. (Libertyville, IL). Antibodies: Anti-RyR (Affinity Bioreagents, cat. MA3-916, Golden, CO; 1:2,000), anti-Cys NO antibody (Sigma, cat. N0409, St. Louis, MO; 1:2,000), anti-calstabin antibody (Santa Cruz Biotechnology, cat. sc-6173, Santa Cruz, CA; 1:2,500), anti-DNP (Oxyblot, Millipore, Darmstadt, Germany; 1:250), anti-pSMAD3 (Abcam, cat. ab40854, Cambridge, UK; 1:1000), anti-SMAD3 (Abcam, cat. 52903, Cambridge, UK; 1:1000), anti-Nox4 (Abcam, cat. 109225, Cambridge, UK; 1:1000), anti-GAPDH (Sigma, cat. G8795, St. Louis, MO; 1:500) and anti-tubulin (Sigma, cat. 8203, St. Louis, MO; 1:500 each). Fluo-4 AM and Fura-red were obtained from Invitrogen/Molecular probes (cat. F-14201 and cat. F-3020, Eugene, OR).
Waning D.L., Mohammad K.S., Reiken S., Xie W., Andersson D.C., John S., Chiechi A., Wright L.E., Umanskaya A., Niewolna M., Trivedi T., Charkhzarrin S., Khatiwada P., Wronska A., Haynes A., Benassi M.S., Witzmann F.A., Zhen G., Wang X., Cao X., Roodman G.D., Marks A.R, & Guise T.A. (2015). Excess TGF-β mediates muscle weakness associated with bone metastases in mice. Nature medicine, 21(11), 1262-1271.
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