For demonstration purposes, two datasets are presented, both acquired with informed consent under a UIC IRB approved protocol, one healthy and one with glioblastoma (GBM). Healthy: 3T Discovery MR750 (GE Medical Systems, Waukesha, Wi, USA), 8 channel head coil, SE-EPI, TR/TE (3000/91 ms), FOV (240x240x5 mm3), slice gap (5 mm), matrix acquired (128x128) image (256x256), b-values (0/1, 10/1, 50/1, 100/1, 300/1, 400/1, 500/1, 700/1, 1000/1, 1250/1, 1800/2, 2000/2, 2500/2, 3000/3, 3300/3, 3500/3, 3700/, 3800/3, 4000/4, 4300/4, 4600/4, 5000/4 – s/mm2 / averages), acquisition time = 7.0 min. Glioma patient: 3T Discovery MR750 (GE Medical Systems, Waukesha, Wi, USA), 8 channel head coil, SE-EPI, TR/TE (3200/99 ms), FOV (240x240x3 mm3), slice gap (3 mm), matrix acquired (256x256) image (256x256), b-values (0/4, 20/1, 50/1, 80/1, 100/1, 150/1, 200/1, 400/1, 600/1, 800/1, 1000/1, 1200/2, 1500/2, 2000/2, 2400/2, 2800/2, 3200/4, 3600/4, 4000/4, 4500/4, 5000/4 – s/mm2 / averages), acquisition time = 7.0 min. Both acquired 3 orthogonal directions to produce trace images.
3t discovery mr750
Manufactured by GE Healthcare
Sourced in United States
The 3T Discovery MR750 is a 3 Tesla magnetic resonance imaging (MRI) system designed and manufactured by GE Healthcare. It is capable of generating high-quality, high-resolution images of the human body for diagnostic purposes.
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35 protocols using 3t discovery mr750
1
Diffusion-Weighted MRI Protocols for Glioblastoma
2
PET/CT-MRI Multimodal Imaging Protocol
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All of the patients underwent a tri-modality PET/CT-MRI (full ring; time-of-flight Discovery PET/CT 690; 3T Discovery MR 750; GE Healthcare) comprising a sequential whole-body 18F-FDG PET/CT and a regular head and neck MRI. The patients were positioned on a dedicated shuttle board, facilitating their transport from the PET/CT to the MRI system without movement.
3
Structural and Diffusion MRI Acquisition
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MRI scans were acquired at the Center for Cognitive and Neurobiological Imaging (CNI) at Stanford University using a 3T Discovery MR750 (GE Medical Systems, Milwaukee, WI) equipped with a 32-channel head coil (Nova Medical). For all participants, T1-weighted images were acquired using a SPGR sequence (TR/TE/TI = 6.24/2.34/450 ms; flip angle = 12°; sagittal slices; 0.9 mm isotropic voxels) and a diffusion-weighted EPI sequence (TR/TE = 8500/93.5 ms; b = 2000 mm2/s, 64 axial slices, 2 mm isotropic voxels; 60 gradient directions, and 6 b = 0 images acquired at the beginning of the scan).
4
High-Quality Structural MRI Acquisition
5
High-Resolution T1-Weighted MRI Acquisition
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MRI scans were acquired at the Center for Cognitive and Neurobiological Imaging at Stanford University using a 3 T Discovery MR750 (GE Medical Systems, Milwaukee, WI, USA) equipped with a 32-channel head coil (Nova Medical, Wilmington, MA, USA). Whole-brain T1-weighted images (T1w) were collected using the following spoiled gradient echo pulse sequence: 186 sagittal slices; TR (repetition time)/TE (echo time)/TI (inversion time) = 6.24/2.34/450 ms; flip angle = 12°; voxel size = 0.9 mm × 0.9 mm × 0.9 mm; scan duration = 5:15 min.
6
High-Resolution T1-Weighted Anatomical MRI
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A routine T1-weighted anatomical scan (BRAVO sequence, GE Healthcare, 3T Discovery MR750) was acquired for anatomical coregistration as part of a 1-hour MRI protocol. Resolution was 0.9 mm isotropic; TE/TR = 3.00 ms/6.74 ms; TI = 650 ms; flip angle = 8°; scan time: 4 min and 42 s.
7
Diffusion-weighted Imaging of the Brain
8
Retrospective Review of Prostate mpMRI
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An Institutional Review Board (IRB) approved a protocol for retrospective review of mpMRI exams from prostate cancer patients. The IRB waived the need for informed consent. A total of 71 sequential patients, presenting for evaluation for radiation treatment (RT) between 2012 and 2015 and who underwent mpMRI exams on a 3T Discovery MR750 (GE, Waukesha, WI, USA) were identified from the departmental database.
mpMRI exam consisted in part of: (i) axial T2w-MRI of the pelvis: resolution 1.25 mm × 1.25 mm × 2.5 mm; field of view: 320 mm × 320 mm; slice thickness = 2.5 mm (no gap); 72 slices, and (ii) DCE-MRI—12 series of T1 weighted (T1w) at 30–34 s temporal resolution, TR = 3.77–4.05 ms, TE = 1.69–1.78 ms acquired following intravenous bolus injection of a paramagnetic gadolinium chelate—0.1 mmol of gadobenate-glumine (Bracco Diagnostics Inc., Princeton, NJ, USA) per kilogram of body weight. The contrast is administered with a power injector (Spectris, Medrad Inc., Warrendale, PA, USA) at 2 mL/s and followed by a 20-mL saline flush.
mpMRI exam consisted in part of: (i) axial T2w-MRI of the pelvis: resolution 1.25 mm × 1.25 mm × 2.5 mm; field of view: 320 mm × 320 mm; slice thickness = 2.5 mm (no gap); 72 slices, and (ii) DCE-MRI—12 series of T1 weighted (T1w) at 30–34 s temporal resolution, TR = 3.77–4.05 ms, TE = 1.69–1.78 ms acquired following intravenous bolus injection of a paramagnetic gadolinium chelate—0.1 mmol of gadobenate-glumine (Bracco Diagnostics Inc., Princeton, NJ, USA) per kilogram of body weight. The contrast is administered with a power injector (Spectris, Medrad Inc., Warrendale, PA, USA) at 2 mL/s and followed by a 20-mL saline flush.
9
High-resolution 3T MRI Brain Imaging
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MRI scans were acquired at the Center for Cognitive and Neurobiological Imaging at Stanford University using a 3T Discovery MR750 (GE Medical Systems, Milwaukee, WI, USA) equipped with a 32-channel head coil (Nova Medical, Wilmington, MA, USA). Whole-brain T1-weighted images (T1w) were collected using the following spoiled gradient echo pulse sequence: 186 sagittal slices; TR (repetition time)/TE (echo time)/TI (inversion time) = 6.24/2.34/450 ms; flip angle = 12°; voxel size = 0.9 mm × 0.9 mm × 0.9 mm; scan duration = 5:15 min.
10
High-Resolution MRI and Diffusion Imaging
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All participants were MRI scanned by a 3 T Discovery MR750 (GE Medical Systems, Milwaukee, WI) with a 32-channel head coil (Nova Medical) at the Stanford Center for Cognitive and Neurobiological Imaging. A high-resolution T1-weighted anatomical scan was acquired using an SPGR sequence (TR/TE/TI = 6.24/2.34/450 ms; flip angle = 12°; 186 sagittal slices; 0.9 mm isotropic voxels). Diffusion-weighted imaging was acquired using an EPI sequence (TR/TE = 8500/93.5 ms; 64 axial slices; 2 mm isotropic voxels; 60 b = 2000 diffusion-weighted directions, and 6 b = 0 acquisitions at the beginning of the scan; A/P phase encoding direction).
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