Nevirapine

Manufactured by Selleck Chemicals

Sourced in China

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used as a pharmaceutical compound in the treatment of HIV/AIDS. It is a white to pale yellow crystalline powder.

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Lab products found in correlation

5 protocols using nevirapine

Inhibition of HIV-1 Infection

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CS, PSA, and PNS were obtained from Acros Organics (Morris Plains, NJ), PolyScience, Inc. (Warrington, PA), and BASF (Parsippany, NJ), respectively. SPL7013, the active ingredient of VivaGel®, was obtained from Starpharma and dissolved in PBS (100 mg/ml). Monoclonal Antibodies (2F5, 2G12) were purchased from Polymun. Maraviroc (MVC) was obtained from Pfizer. Nevirapine, Tenofovir disoproxil fumarate and Elvitegravir were purchased from Selleckchem. Indinavir was provided from the NIH AIDS Research and Reference Reagent Program (ARRRP). SEVI was generated as described (8 (link)).

Zirafi O., Kim K.A., Roan N.R., Kluge S.F., Müller J.A., Jiang S., Mayer B., Greene W.C., Kirchhoff F, & Münch J. (2014). HIV enhancing activity of semen impairs the antiviral efficacy of microbicides. Science translational medicine, 6(262), 262ra157.

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Antiretroviral Compounds for Research

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Control compounds such as nevirapine (NVP), efavirenz (EFV), and azidothymidine (AZT) were obtained from the NIH AIDS Research and Reference Reagent Program. Raltegravir (RAL), dolutegravir (DTG), nevirapine (NVP), indinavir (IDV), AZT, ribavirin (RBV), lopinavir (LPV), darunavir (DRV), tenofovir (TFV), lamivudine (3TC), didanosine (ddI), emtricitabine (FTC), abacavir (ABC), efavirenz (EFV), etravirine (ETV), rilpivirine (RPV), and elvitegravir (EVG) were purchased from Selleck Chemicals.

Bonnard D., Le Rouzic E., Singer M.R., Yu Z., Le Strat F., Batisse C., Batisse J., Amadori C., Chasset S., Pye V.E., Emiliani S., Ledoussal B., Ruff M., Moreau F., Cherepanov P, & Benarous R. (2023). Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase. Antimicrobial Agents and Chemotherapy, 67(7), e00462-23.

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Oral gavage of anti-HIV drugs

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Lamivudine (Selleckchem, S1706) and nevirapine (Selleckchem, S1742) were dissolved in PBS at the concentration of 2 mg/ml and 1 mg/ml, respectively, and 100 μl solution was given to the mice with oral gavage daily (200 μg/day and 100 μg/day, respectively) for 4 weeks, starting from 4-week of age and up to 8-wk of age. On the next day of the final treatment, the mice were evaluated for ataxia scoring and rotarod tests, euthanized, and the cerebella were collected for experiments.

Takahashi T., Stoiljkovic M., Song E., Gao X.B., Yasumoto Y., Kudo E., Carvalho F., Kong Y., Park A., Shanabrough M., Szigeti-Buck K., Liu Z.W., Kristant A., Zhang Y., Sulkowski P., Glazer P.M., Kaczmarek L.K., Horvath T.L, & Iwasaki A. (2022). LINE-1 activation in the cerebellum drives ataxia. Neuron, 110(20), 3278-3287.e8.

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Antiretroviral Compounds Procurement

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Nevirapine (catalog #S1742), efavirenz (catalog #S4685) and delavirdine mesylate (catalog #S6452) were purchased from Selleck Chemicals (https://www.selleckchem.com/). Soluble human TNF-α (catalog # Z01001) was purchased from GenScript (http://www.genscript.com).

Eguida M, & Rognan D. (2021). Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. Journal of Cheminformatics, 13, 90.

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Evaluating Anti-HIV Drug Efficacy in Patient Samples

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Plasma samples from HIV-1 infected patients were provided by the center of disease prevention and control (CDC), Shenzhen, China. All patients had been treated with antiviral drugs in the past years. All participating patients signed an informed consent for sample collection and testing. This study was approved by the Medical Ethics Committee of Southern Medical University (permit numbers: NFYY-2008-045), Guangzhou, China. All experiments were carried out in accordance with the approved guidelines.
Twelve HIV-1 inhibitors were used in this study, including six nucleoside reverse-transcriptase inhibitors (NRTIs): Didanosine (DDI), Stavudine (D4T), Zidovudine (AZT), Zalcitabine (DDC), Emtricitabine (FTC), Abacavir Sulfate (ABC), four non-nucleoside reverse transcriptase inhibitors (NNRTIs): Nevirapine (NVP), Etravirine (ETR), Dapivirine (DPV), Rilpivirine (RPV), and two protease inhibitors (PIs): Nelfinavir (NFV) and Lopinavir (LPV), which were purchased commercially from Selleckchem (Shanghai, China).

Weng Y., Zhang L., Huang J., Zhao J., Luo P., Bi S., Yang Z., Zhu H., Allain J.P, & Li C. (2016). A simple and cost-saving phenotypic drug susceptibility testing of HIV-1. Scientific Reports, 6, 33559.

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