Trc 50dx retinal camera

Manufactured by Topcon

Sourced in Japan

The TRC-50DX retinal camera is a precision instrument designed for capturing high-quality digital images of the human retina. It features a non-mydriatic imaging system, which means it can take photographs of the retina without the need for pupil dilation.

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Lab products found in correlation

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Spelling variants of this product

TRC-50DX (86 citations) Topcon TRC 50DX camera (10 citations)

15 protocols using trc 50dx retinal camera

Comprehensive Ophthalmic Evaluation for AMD

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All participants underwent a complete ophthalmoscopic examination, including measurement of best-corrected visual acuity (BCVA) with the ETDRS chart, measurement of intraocular pressure, slit lamp examination, and dilated fundus exam. Presence of AMD features (drusen, pigmentary change, PED, CNV, GA) and other ocular findings (e.g., phakic status) were documented. Color fundus photos and fundus autofluorescence (FAF) images were acquired with the TRC-50DX retinal camera (Topcon Medical Systems, Tokyo, Japan). Infrared reflectance (IR) and FAF images and spectral domain optical coherence tomography (SD-OCT) scans were acquired with the Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany). Each set of SD-OCT scans consisted of 37 B-scans, each of which was composed of 24 averaged scans, obtained within a 30° × 15° rectangle centered on the fovea. In addition, enhanced depth imaging OCT (EDI-OCT) scans were acquired for improved visualization of the choroid in a single horizontal scan centered at the fovea obtained over a distance of 30° consisting of 100 averaged scans.

Flamendorf J., Agrón E., Wong W., Thompson D., Wiley H., Doss E., Al-Holou S., Ferris F 3.r.d., Chew E, & Cukras C. (2015). Impairments in Dark Adaptation are Associated with Age-Related Macular Degeneration Severity and Reticular Pseudodrusen. Ophthalmology, 122(10), 2053-2062.

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Longitudinal Assessment of Retinal Structures

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Participants underwent measurement of best-corrected visual acuity (BCVA), using the Early Treatment Diabetic Retinopathy Study chart; ophthalmoscopic examination; and retinal imaging during both baseline and 4-year follow-up visits that took place at least 48 months after the initial visit. Color fundus photographs and fundus autofluorescence images were acquired with the TRC-50DX retinal camera (Topcon Medical Systems, Oakland, NJ, USA). Infrared reflectance and fundus autofluorescence images were acquired with the Spectralis system (Heidelberg Engineering, Heidelberg, Germany). Choroidal assessments were performed using enhanced depth imaging (EDI) SD-OCT scans acquired with the Spectralis instrument as a single horizontal B-scan (scan length of 8.7 mm comprised of 768 A-scans averaged over 100 individual repeated B-scans) centered at the fovea. Retinal thickness assessments were acquired with the Cirrus HD-OCT instrument (Carl Zeiss Meditec, Jena, Germany) using a 512 × 128 volume scan pattern with a 6 × 6-mm area centered on the fovea. All scans were manually assessed by two readers to achieve adequate quality and positioning of the retina that would allow accurate measurement of retinal thickness.

Chiang T.T., Keenan T.D., Agrón E., Liao J., Klein B., Chew E.Y., Cukras C.A, & Wong W.T. (2020). Macular Thickness in Intermediate Age-Related Macular Degeneration Is Influenced by Disease Severity and Subretinal Drusenoid Deposit Presence. Investigative Ophthalmology & Visual Science, 61(6), 59.

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Retinal Image Preprocessing for Neural Networks

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All retinal images were captured using a fundus camera (TRC-50DX Retinal Camera; Topcon Corporation, Tokyo, Japan). The full-resolution images were converted to JPEG with center cropping, random flipping horizontally and vertically, random rotation within 30° for data augmentation, random brightness with an adjustment factor of 0.1, and random zoom with an adjustment factor of 0.1; they were then converted to a resolution of 448 × 448 pixels for use in the neural network. All images and EMR from eligible patients were identified before their transfer to data analysts.

Lee Y.C., Cha J., Shim I., Park W.Y., Kang S.W., Lim D.H, & Won H.H. (2023). Multimodal deep learning of fundus abnormalities and traditional risk factors for cardiovascular risk prediction. NPJ Digital Medicine, 6, 14.

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Optic Nerve Imaging in Animal Model

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Color fundus photographs captured at 35° were performed on anesthetized animals using a retinal camera (TRC-50DX Retinal Camera; Topcon, Tokyo, Japan) with a Nikon 200 D digital camera. Pupils were sufficiently dilated (8 mm) with 0.25% tropicamide eye drops (Mydrin, Santen Pharmaceutical) and an ocular lubricating agent (Artificial Tears; Zhongshan Ophthalmic Center) was applied to preserve corneal clarity during the examination. The narrowed neuroretinal rim and enlarged optic cup were observed in the animal model.

Tu S., Li K., Hu D., Li K, & Ge J. (2019). Posture-Dependent 24-Hour Intraocular Pressure Fluctuation Patterns in an Intraocular Hypertension Monkey Model. Translational Vision Science & Technology, 8(3), 63.

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Angiographic Evaluation of AMD Subtypes

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Fluorescein angiography and indocyanine green (ICG) angiography were performed using a Topcon TRC 50DX retinal camera (Topcon, Tokyo, Japan) to diagnose AMD and determine its subtypes, polypoidal choroidal vasculopathy (PCV) and retinal angiomatous proliferation (RAP). Angiographic grading was carried out according to the TAP criteria by retina specialists in our clinic (MS, NN and YO).7 (link) Using fluorescein angiography, significant pigment epithelial detachment (PED) was defined according to the lesion diameter: serous PED>4 disc diameters (DD), haemorrhagic PED>4 DD, and fibrovascular PED>3 DD.

Suzuki M., Nagai N., Izumi-Nagai K., Shinoda H., Koto T., Uchida A., Mochimaru H., Yuki K., Sasaki M., Tsubota K, & Ozawa Y. (2014). Predictive factors for non-response to intravitreal ranibizumab treatment in age-related macular degeneration. The British Journal of Ophthalmology, 98(9), 1186-1191.

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Evaluating Visual Acuity Changes in Ophthalmology

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Clinical data were extracted from the medical records. Best-corrected visual acuity (BCVA) was measured using the early treatment of diabetic retinopathy study chart. Intraocular pressure was measured with a noncontact tonometer (NT-530; Nidek Co., Ltd, Japan). Fundus color photography and FFA examinations were performed using a TRC-50DX retinal camera (Topcon Medical Systems Inc., Japan). Spectral-domain OCT was carried out with a Spectralis system (Heidelberg Engineering GmbH, Germany). The central macular thickness was measured in high-definition scanning mode. The change in vision at each follow-up was evaluated as follows: an increase of ≥ 15 in the number of letters in the chart was considered a substantial improvement in vision; an increase of 5–14 was considered an improvement in vision; an increase or decrease of < 5 was considered stable vision; a decrease of 5–14 was considered a worsening of vision; and a decrease of ≥ 15 was considered a substantial worsening of vision[25 (link)].

Jiang L., Qin B., Luo X.L., Cao H., Deng T.M., Yang M.M., Meng T, & Yang H.Q. (2020). Three-year follow-up of Coats disease treated with conbercept and 532-nm laser photocoagulation. World Journal of Clinical Cases, 8(24), 6243-6251.

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Comprehensive Multimodal Imaging for AMD

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All participants underwent a complete ophthalmoscopic examination, including measurement of BCVA with the Early Treatment Diabetic Retinopathy Study chart, measurement of intraocular pressure, slit-lamp examination, and dilated fundus examination. Presence of AMD features (drusen, pigmentary change, pigment epithelial detachment, CNV, central geographic atrophy) and other ocular findings (e.g., phakic status) were documented. Color fundus photographs (50 degrees) and fundus autofluorescencc (FAF) (50 degrees, excitation wavelength 575 nm) images were acquired with the TRC-50DX retinal camera (Topcon Medical Systems, Tokyo, Japan). Infrared reflectance (IR), FAF images (30 degrees, excitation wavelength 488 nm), and spectral-domain (SD) OCT scans were acquired with the Heidelberg Spcctralis (Heidelberg Engineering, Heidelberg, Germany). Each set of SD OCT scans consisted of 37 B-scans, each of which comprised 24 averaged scans, obtained within a 30° × 15° rectangle centered on the fovea with the Automated Real Time Averaging mode set to 25 images averaged and a minimum scan quality measure of 20 decibels or greater with most scans ranging from 30 to 40 decibels. In addition, enhanced depth imaging OCT scans were acquired for improved visualization of the choroid in a single horizontal scan centered at the fovea obtained over a distance of 30° consisting of 100 averaged scans.

Chen K.G., Alvarez J.A., Yazdanie M., Papudesu C., Wong W.T., Wiley H.E., Keenan T.D., Chew E.Y., Ferris FL I.I.I, & Cukras C.A. (2018). Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration. Ophthalmology, 126(6), 856-865.

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Evaluation of Radiation Retinopathy

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Digital color fundus photographs were taken with a Topcon TRC 50-DX retinal camera (Topcon, Tokyo, Japan), which generated an image size of 2392 × 2048 pixels from an OIS full frame 36 mm sensor, with an effective resolution of 4.89 megapixels. The images were evaluated and viewed with Zeiss Forum software (Carl Zeiss Meditec, Inc.) using a 27-inch, 5120 × 2880-pixel built-in retina display (Apple Corp, Cupertino, CA).
Two expert examiners (EMB, RHK) independently evaluated the presence of radiation retinopathy within the macula between the superior and inferior temporal retinal arteriole arcades. The examiners were masked to the treatment details and time point of the radiation treatment. The images were classified as abnormal if any of the following features of radiation retinopathy were detected within the macula (defined by the temporal vascular arcades): intraretinal hemorrhages, microaneurysms, sclerotic vessels, telangiectatic vessels, cotton wool spots, or hard exudates.
Further, OCT volume scans (OCT Spectralis, Heidelberg Engineering, Franklin, MA) were evaluated (by EMB) for radiation retinopathy. Scans were classified as abnormal if any of the following features of radiation retinopathy were detected: intraretinal or subretinal fluid or abnormal retinal thickening.

Tamplin M.R., Deng W., Garvin M.K., Binkley E.M., Hyer D.E., Buatti J.M., Ledolter J., Boldt H.C., Kardon R.H, & Grumbach I.M. (2021). Temporal Relationship Between Visual Field, Retinal and Microvascular Pathology Following 125I-Plaque Brachytherapy for Uveal Melanoma. Investigative Ophthalmology & Visual Science, 62(1), 3.

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Fundus Imaging in Anesthetized Animals

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A color fundus photograph of 35° of the eye was obtained weekly in anesthetized animals in the prone position (with the body placed in the prone position and the head then held and adjusted to a nearly upright position suitable for measurement) using a retinal camera (TRC-50DX Retinal Camera, Topcon, Tokyo, Japan) with a Nikon 200 D digital camera. Surface topical anesthesia was applied after the eye was opened. The pupils were sufficiently dilated (≥8 mm) with a 0.25% tropicamide ophthalmic solution (Mydrin^®, Santen Pharmaceutical, Osaka, Japan). The clarity of the corneas was preserved with an ocular lubricating agent (Artificial tears^®, Zhongshan Ophthalmic Center, Guangdong, China) during the examination. The narrowed neuroretinal rim and the enlarged optic cup were observed in the animal model.

Tu S., Li K., Ding X., Zuo C., Hu D, & Ge J. (2019). TonoVet versus Tonopen in a high intraocular pressure monkey model. Molecular Vision, 25, 391-399.

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Longitudinal Ophthalmic Evaluation Protocol

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The patients in this study are enrolled in a protocol at the National Eye Institute, National Institutes of Health (NIH), Bethesda, MD. The protocol was approved by the NIH Institutional Review Board and adheres to the tenets of the Declaration of Helsinki.
Both patients underwent a complete ophthalmoscopic examination including best-corrected visual acuity testing (BCVA), slit lamp examination, and dilated fundus exam. Color fundus photos were acquired with the TRC-50DX retinal camera (Topcon Medical Systems, Oakland, NJ). Fundus autofluorescence (FAF) and near infrared reflectance (NIR-R) fundus images and spectral domain optical coherence tomography (SD-OCT) scans were acquired with the Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany). OCT scans either consisted of 19 B scans, each composed of 14 averaged scans, covering an area of 20° × 15° encompassing the macula; or they consisted of 37 B scans, each composed of 25 averaged scans, covering an area of 30° × 15° encompassing the macula. Patients repeated the ophthalmic studies and imaging studies approximately yearly over the course of 8 years.

Cukras C., Flamendorf J., Wong W.T., Ayyagari R., Cunningham D, & Sieving P.A. (2016). Longitudinal Structural changes in Late-onset Retinal Degeneration. Retina (Philadelphia, Pa.), 36(12), 2348-2356.

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