Jms 600w vg trio 2 gc ms

All chemical reagents were commercially available and used without further purification. Melting points were determined using the M5000 Melting Point apparatus (Kruss, Hamburg, Germany) and used without any correction. Proton nuclear magnetic resonance (NMR) spectra were recorded using the Avance-500 spectrometer (Bruker, Billerica, MA, USA) at 500 MHz. Chemical shifts are reported in ppm, and Me4Si was used as the reference standard. Mass spectra were recorded using JMS-600W VG Trio-2 GC-MS (Jeol, Akishima, Japan). Reaction products were purified by flash column chromatography using silica gel 60 (230–400 mesh) and monitored by thin-layer chromatography with precoated silica gel 60 F254 (Merck, Darmstadt, Germany). Spots were visualized under UV light (254 nm) after staining with PMA or Hanessian solution.
5-(4-Fluorophenyl)-N-phenyloxazol-2-amine (7c). Pale yellow solid, mp = 160–162 °C, ¹H NMR (300 MHz, DMSO-d₆) δ 10.31 (s, 1H), 7.57–7.68 (m, 5H), 7.26–7.35 (m, 4H), 6.89–7.03 (m, 1H); MS (FAB) m/z 254 (M⁺).

All chemical reagents were commercially available and were used without further purification. Melting points were determined using a Kruess M5000 melting point apparatus and were not corrected. Proton NMR spectra were recorded on an Avance-500 (Bruker, Billerica, MA, USA) at 500 MHz. Chemical shifts were reported in ppm units with Me4Si as the reference standard. Mass spectra were recorded on a JEOL, JMS-600W VG Trio-2 GC–MS. Reaction products were purified using flash column chromatography with silica gel 60 (230–400 mesh, Merck, Mumbai, India) and monitored using TLC on precoated silica gel 60 F254 (Merck). Spots were visualized under UV light (254 nm) after staining with phosphomolybdic acid (PMA) or Hanessian’s solution. The details have been described in the supplementary materials and methods section and Supplementary Scheme S1.