Mitocin

Manufactured by Bristol-Myers Squibb

Sourced in Brazil

Mitocin is a laboratory equipment product designed for cellular and molecular biology applications. It is used for the analysis and detection of mitochondrial function and activity. The core function of Mitocin is to provide researchers with a tool to study the mitochondria, which are the powerhouses of cells.

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Lab products found in correlation

Ethyl methanesulphonate, by Merck Group (1 mentions) Formula 4 24 instant drosophila medium, by Carolina Biological Supply (1 mentions) Bevacizumab, by Bristol-Myers Squibb (1 mentions) Avastin, by Genentech (1 mentions)

2 protocols using mitocin

Drosophila Mutagenicity Assay Protocols

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The mutagens ethyl methanesulphonate (EMS, CAS n° 62-50-0; Sigma-Aldrich, Saint
Louis, MO, USA) and mitomycin C (MMC, CAS n° 50-07-5, Mitocin^®,
Bristol-Myers Squibb, Brazil) were dissolved in distilled water just before
treatment. The mutagen doses used were established in previous pilot studies
conducted in our laboratory to accurately evaluate antimutagenicity of HSCAN and
other compounds. Drosophila Instant Medium Formula 4-24 was purchased from Carolina
Biological Supply (Burlington, NC, USA) and powdered cellulose, from Merck
(Darmstadt, Germany).

da Silva R.A., Dihl R.R., Dias L.P., Costa M.P., de Abreu B.R., Cunha K.S, & Lehmann M. (2016). DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster. Genetics and Molecular Biology, 39(3), 431-441.

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Comparison of Bevacizumab and Mitomycin C in Glaucoma

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GFS was performed by a single surgeon on the right eye only. The surgeries were performed with the animals under general anesthesia by intramuscular injection of ketamine 50 mg/mL and xylazine 2%. The animals were randomly allocated into three groups according to the medications used during the surgery:
Group A: bevacizumab (Avastin ® , Genentech, San Francisco, CA, USA). Subconjunctival injection using a 27-gauge needle (1.25-0.05 mL), adjacent to the site of the surgery at the end of the procedure.
Group B: MMC (Mitocin ® , Bristol-Myers Squibb, São Paulo, SP, Brazil) (0.2 mg/mL) soaked in a semilunar 8-mm diameter sponge (25.12 mm 2 area), placed between the Tenon capsule and sclera for 3 min, followed by continuous irrigation with 20 mL of balanced salt solution and subconjunctival injection of bevacizumab as described above.
Group C: MMC application alone, as previously described.

Hilgert C.R., Hilgert A.H., Odashiro A.N., Odashiro P.R.P, & Paranhos A J.r. (2018). Antiscarring effect of intraoperative bevacizumab in experimental glaucoma filtration surgery. Arquivos brasileiros de oftalmologia, 81(4).

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