1 naphthohydroxamic acid

Manufactured by Merck Group

1-naphthohydroxamic acid is a chemical compound used in laboratory settings. It is a naphthalene derivative with a hydroxamic acid functional group. The core function of this product is to serve as a reagent or intermediate in various chemical reactions and analyses, but no further details about its intended use can be provided in an unbiased and factual manner.

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Lab products found in correlation

Valproic acid, by Merck Group (1 mentions) Vorinostat, by Merck Group (1 mentions) Mc1568, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Panobinostat, by LC Laboratories (1 mentions) Entinostat, by LC Laboratories (1 mentions) Butyrate, by Merck Group (1 mentions) Propionate, by Merck Group (1 mentions) Mhy1485, by Merck Group (1 mentions) Tubacin, by Merck Group (1 mentions) Rgfp966, by Merck Group (1 mentions) Bafilomycin a1, by Merck Group (1 mentions)

2 protocols using 1 naphthohydroxamic acid

Characterization of HDAC Inhibitor Compounds

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HDAC inhibitors (Table 1) were purchased from the following: belinostat (Cat. No. S1085; CAS No. 414864-00-9, Selleck Chemicals, Houston, TX), entinostat (E-3866; CAS No. 209783-80-2) and panobinostat (P-3703; CAS No. 404950-80-7, LC Laboratories, Woburn, MA), and remaining compounds were from Sigma-Aldrich, St. Louis, MO: APHA (3-(4-aroyl-1H-2-pyrrolyl)-N-hydroxypropenamide) compound 8 (A2478; CAS 676599-90-9), MC1568 (M1824; CAS No. 852475-26-4), 1-naphthohydroxamic acid (SML0078; CAS 6953-61-3), SAHA (suberoylanilide hydroxamic acid, Vorinostat; SML0061; CAS 149647-78-9), sodium butyrate (B5887; CAS No. 156-54-7), trichostatin A (T-8552; CAS No. 58880-19-6), tubastatin A hydrochloride (SML0044; CAS 1310693-92-5), valproic acid (PHR1061; CAS 99-66-1). valproic acid was supplied as a solution whereas all other inhibitors were supplied in powdered form. A concentrated stock solution of sodium butyrate was prepared in sterile water. Concentrated stock solutions of the remaining inhibitors were prepared in dimethyl sulfoxide (DMSO; Sigma-Aldrich).

Cody J.J., Markert J.M, & Hurst D.R. (2014). Histone Deacetylase Inhibitors Improve the Replication of Oncolytic Herpes Simplex Virus in Breast Cancer Cells. PLoS ONE, 9(3), e92919.

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Histone Deacetylase Inhibitor Evaluation

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All chemicals Butyrate (1mM), Acetate (1mM), Propionate (1mM), SAHA (1μM), SBHA (20μM), TMP195 (10 μM), RGFP966 (20 μM), 1-NA (10 μM), tubacin (1μM), 1-naphthohydroxamic acid, bafilomycin A1, 3-MA, MHY1485) were purchased from Sigma-Aldrich, unless specified otherwise. TMP195 was acquired from Cellagen technology and Cayman chemical respectively. Recombinant human and murine M-CSF were purchased from PeproTech.

Schulthess J., Pandey S., Capitani M., Rue-Albrecht K.C., Arnold I., Franchini F., Chomka A., Ilott N.E., Johnston D.G., Pires E., McCullagh J., Sansom S.N., Arancibia-Cárcamo C.V., Uhlig H.H, & Powrie F. (2019). The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages. Immunity, 50(2), 432-445.e7.

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