B6 cg gt rosa 26sortm1

Irg1^−/− C57BL/6N mice were described previously (Lampropoulou et al., 2016 (link)). C57BL/6N used as WT controls in experiments with Irg1^−/− mice were obtained from Charles River Laboratories. B6.129X1-Nfe2l2^tm1Ywk/J (Nrf2^−/−), C57BL/6N-Gsdmd^em4Fcw/J (Gsdmd^−/−), B6.Cg-Gt(ROSA)26Sor^{tm1(CAG-Pycard/mCitrine*,-CD2*)Dtg}/J (ASC-mCitrine (Tzeng et al., 2016 (link)), B6.129P2-Nos2^tm1Lau/J (Nos2^−/−), B6(Cg)-Ifnar1^tm.2Ees/J (Ifnar1^−/−) and WT C57BL/6J mouse strains were purchased from Jackson Laboratory. ROSA26-CreER^T2/SDHB^{floxed/floxed} (Sdhb^fl/fl) and ROSA26-CreER^T2/SDHB^{wild-type/wild-type} mice (Sdhb WT) as previously published (Cardaci et al., 2015 (link)) were provided by Eyal Gottlieb (University of Glasgow, UK). Mice were maintained at Washington University under specific pathogen-free conditions in accordance with Federal and University guidelines and protocols approved by the Animal Studies Committee of Washington University. Femurs and tibias from Atf3^−/− mice as described (Jiang et al., 2004 (link)) were provided by Tsonwin Hai (Ohio State University). Mice used for in vitro experiments were 8- to 24-week-old, age and sex-matched and both sexes were used. For in vivo experiments 9 to 14-week-old female mice were used in the model of endotoxin-induced sepsis and 10 to 12-week-old male mice were used in the psoriasis model.