Optive

Manufactured by Abbvie

Sourced in Germany

Optive is a lab equipment product designed for various laboratory applications. It serves as a versatile tool for researchers and scientists, enabling them to perform a range of tasks within the laboratory environment.

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Lab products found in correlation

Pred forte, by Abbvie (2 mentions) Moxifloxacin hydrochloride, by Alcon (2 mentions) Vigamox, by Alcon (2 mentions) Systane balance, by Alcon (1 mentions) Vigadexa, by Alcon (1 mentions) Visumax fs, by Zeiss (1 mentions)

7 protocols using optive

Comparative Evaluation of Dry Eye Treatments

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Male Wistar rats (Centre d'élevage Janvier, Le Genest Saint Isle, France), 7–8 weeks of age, were used in these experiments. The Iris Pharma Institute Animal Care and Use Committee approved the protocol, and all animals were treated according to the Association for Research in Vision and Ophthalmology statement for the Use of Animals in Ophthalmic and Vision Research.
Rats were randomly assigned to 7 groups, including a normal control group without any corneal defect. The other groups were subjected to corneal abrasion and received topical treatments with phosphate-buffered saline (PBS), 0.02% BAK solution (benzalkonium chloride in PBS), Systane Balance^® (Alcon Laboratories, Inc.), Optive^® (Allergan, Inc.), Vismed^® (Horus Pharma), or Cationorm (Santen SAS). Ten microliters of each eye drop was applied twice a day for 5 days in both eyes. The treatments were encoded. The treatment allocation was blinded to the technician administering the treatment, and the researcher assessing the outcome of the experiment was blinded to the treatment allocation. Group identification was uncovered at the end of the analysis. ATs are presented in Table 1 with active ingredients and preservatives.

Daull P., Feraille L., Elena P.P, & Garrigue J.S. (2016). Comparison of the Anti-Inflammatory Effects of Artificial Tears in a Rat Model of Corneal Scraping. Journal of Ocular Pharmacology and Therapeutics, 32(2), 109-118.

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Postoperative Topical Treatment and Evaluation

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In the immediate postoperative period, topical treatment was initiated with a combination of moxifloxacin and dexamethasone (Vigadexa, Alcon) four times a day for 1 week, and lubricant eye drops containing sodium hyaluronate and carboxymethylcellulose (Optive, Allergan) were provided by Oftalmax. The patients were examined by medical researchers who did not participate in the randomization at day 1, week 1, month 1, 3 months and 1 year after the procedure.
During the first three postoperative follow-up visits, possible complications and ocular surface integrity were assessed by anterior segment biomicroscopy, uncorrected distance visual acuity (UDVA), and fundoscopy. The last two visits included the evaluation of the patients’ visual acuity with cycloplegic refraction, retinal mapping, applanation tonometry, and total anterior segment analysis including RMS and HOAs performed by dual Scheimpflug-based corneal system tomography.

Alves E.M., Lyra A.F., Tenório M., Mesquita N., Bacelar C., Montenegro A., Alves L, & Alves M. (2022). Femtosecond laser-assisted in situ keratomileusis with topography-guided or asphericity-adjusted derived data: a comparative contralateral eye study. BMC Ophthalmology, 22, 189.

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Rabbit Cornea OCT Imaging Protocol

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The rabbit was anesthetized, and pupils dilated as above. Application of a corneal lubricant (Optive®, Allergan, Frankfurt, Germany) was done at least every 5 min to moisturize the eye and maintain clear SD-OCT imaging; then, we attached a steel platform to the headrest to stabilize the animal in the required position. We used a 30-degree lens and the following parameters for optimal optical coherence tomography (OCT) imaging: 30 degrees settings for single line scans with automated real-time tracking (ART) mode set to 100 (averaging) and 20 × 20 degree settings for volume scans with ART mode set to 15; high resolution mode was not required. SLO infrared reflectance imaging aided us in finding the focal plane of the RPE-wound.

Al-Nawaiseh S., Krötz C., Rickmann A., Strack C., Germann A., von Briesen H., Szurman P., Schulz A, & Stanzel B.V. (2023). A rabbit model for outer retinal atrophy caused by surgical RPE removal. Graefe's Archive for Clinical and Experimental Ophthalmology, 261(8), 2265-2280.

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Comparative Evaluation of Ophthalmic Drops

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Investigational eye drops comprised a sterile, preservative-free solution for topical ophthalmic use (HYLO CONFORT; Ursapharm), containing 0.1% (1 mg/mL) HA, citrate buffer, sorbitol, and water in a 10 mL bottle. Comparator eye drops comprised a sterile solution for topical ophthalmic use (OPTIVE, Allergan), containing 0.5% (0.5 mg/mL) CMC, glycerol 0.9%, l-carnitine, erythritol, PURITE 0.1 mg (preservative), and water in a multidose bottle of 10 mL. Both products had to be applied three times daily in the affected eye(s).

Groß D., Childs M, & Piaton J.M. (2018). Comparative study of 0.1% hyaluronic acid versus 0.5% carboxymethylcellulose in patients with dry eye associated with moderate keratitis or keratoconjunctivitis. Clinical Ophthalmology (Auckland, N.Z.), 12, 1081-1088.

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Refractive Lenticule Extraction Protocol

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A single experienced surgeon performed all the surgeries using the VisuMax FS laser system (Carl Zeiss Meditec AG, Jena, Germany) with a 500-kHz repetition rate under topical anesthesia (0.5% proparacaine hydrochloride, Sunways Pvt. Ltd., Maharashtra, India) instilled two to three times under aseptic precautions. Laser cut energy index was 170 nJ. Spot spacing was 2 μm for creation of the lenticule side cut and 4.5 μm for creation of the lenticule. Lenticule and cap diameter was 6.0 and 7.7 mm, respectively. Intended cap thickness was 110 μm. After the refractive lenticule was created, it was dissected and separated through the side-cut opening and removed manually. No fluid hydration or intraoperative massaging of the cornea was performed after lenticule removal. At the end of the procedure, the cornea was moistened with a wet merocel sponge. A drop of moxifloxacin hydrochloride 0.5% (Vigamox, Alcon Laboratories, Inc, Fort Worth, TX) was instilled in both eyes and the procedure was completed. Postoperative treatment included 0.5% moxifloxacin hydrochloride four times a day for 1 week, tapering dose of topical 1% prednisolone acetate suspension (Pred Forte, Allergan, Inc., Irvine, CA) starting from four times a day to once daily for 3 days each and a topical lubricant (Optive, Allergan, Inc.) four times a day for a month.

Shroff R., Francis M., Pahuja N., Veeboy L., Shetty R, & Roy A.S. (2016). Quantitative Evaluation of Microdistortions in Bowman's Layer and Corneal Deformation after Small Incision Lenticule Extraction. Translational Vision Science & Technology, 5(5), 12.

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Longitudinal Retinal Imaging in Rabbits

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Rabbits had repetitive noninvasive retinal imaging performed at post-OP days 4, 7, 14, and 28. Anesthesia and pupil dilation were performed as described above. The cornea was frequently lubricated with artificial tears (Optive, Allergan) to maintain its optical clarity throughout imaging.

Stanzel B.V., Liu Z., Somboonthanakij S., Wongsawad W., Brinken R., Eter N., Corneo B., Holz F.G., Temple S., Stern J.H, & Blenkinsop T.A. (2014). Human RPE Stem Cells Grown into Polarized RPE Monolayers on a Polyester Matrix Are Maintained after Grafting into Rabbit Subretinal Space. Stem Cell Reports, 2(1), 64-77.

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Femtosecond Laser Refractive Surgery

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All surgeries were performed by a single experienced surgeon (R.S.) using the VisuMax femtosecond laser system with a 500 kHz repetition rate and pulse energy of 130 nJ. Preoperative anesthesia comprised proparacaine hydrochloride 0.5% (Paracain, Sunways Pvt Ltd, India) instilled 2 to 3 times under aseptic conditions. Laser cut energy index was preset at 170 nJ, and spot spacing ranged from 2 for the lenticule to 4.5 μm for the lenticular side cut, track distance was 3 mm, and lenticule diameter (optical zone) was 6.0 mm. The cornea above the anterior lenticular surface is referred to as the cap, and its diameter was 7.7 mm. The intended cap thickness was 110 μm. After the femtosecond laser cutting procedure, a standard lamellar corneal surgical technique of swiftly sweeping the dissector across the anterior interface followed by the posterior interface was employed (Fig. 1). Once both layers were separated, the lenticule was removed from the cornea using a pair of microforceps. Postoperative treatment included moxifloxacin hydrochloride 0.5% (Vigamox, Alcon Laboratories, Inc, Fort Worth, TX) for 1 week, topical prednisolone acetate 1% suspension (Pred Forte, Allergan, Inc, Irvine, CA) tapering dose over 2 weeks, and a lubricant (Optive, Allergan, Inc, Irvine, CA) for a month.

Shetty R., Negalur N., Shroff R., Deshpande K, & Jayadev C. (2017). Cap Lenticular Adhesion During Small Incision Lenticular Extraction Surgery: Causative Factors and Outcomes. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), 6(3).

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