Cardio2 cp system

Manufactured by MedGraphics

The CardiO2/CP system is a medical device designed for cardiopulmonary exercise testing. It measures oxygen uptake and carbon dioxide production during exercise to assess cardiovascular and respiratory function.

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CardiO2 System Cardio2

3 protocols using cardio2 cp system

Cardiopulmonary Exercise Testing in PD Patients

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Following completion of initial screening, participants will undergo cardiopulmonary exercise testing (CPX). CPX protocol is administered by an exercise physiologist from the preventative cardiology department of the Cleveland Clinic. Testing will be completed on a Lode cycle ergometer using MedGraphics CardiO₂/CP system with Breeze software. The participant will be instructed to take his/her PD medication as prescribed on the day of testing. A 12-lead electrocardiogram will be assessed prior to exercise, continuously during exercise, and during exercise recovery. Participants will exercise at an initial load of 25 Watts, increasing by 25 Watts every two minutes until 100 Watts, and then increasing by 50 Watts every two minutes until the American College of Sports Medicine’s Guidelines for Exercise Testing criteria for test termination are reached [28 ]. The participant’s peak volume of oxygen uptake (VO₂) will be calculated as the highest 30 second average of VO₂ during the CPX test. A Cleveland Clinic cardiologist will interpret the results of the test, and those with normal responses to exercise will be randomized while those with abnormal responses will be advised for further medical work up.

Rosenfeldt A.B., Rasanow M., Penko A.L., Beall E.B, & Alberts J.L. (2015). The cyclical lower extremity exercise for Parkinson’s trial (CYCLE): methodology for a randomized controlled trial. BMC Neurology, 15, 63.

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Cardiopulmonary Fitness Evaluation Protocol

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All potential study subjects will be pre-screened with the American Heart Association (AHA)/American College of Sports Medicine (ACSM) exercise pre-participation questionnaire [39 ]. Prior to randomization, all potentially eligible subjects will be requested to undergo a cardiopulmonary (CPX) stress test utilizing a semi-recumbent cycle ergometer, similar to the cycle being used for training, and a MedGraphics CardiO2/CP system with Breeze software. We use a continuous incremental protocol starting at 25 Watts (W) and increasing in 10 W stages every two minutes. Subjects are encouraged to continue to exercise to the point of volitional fatigue and the test is terminated per ACSM Guidelines [39 ]. If the initial CPX test is terminated secondary to hemodynamic instability, arrhythmias or ischemic signs, the patient will not be eligible. VO₂ peak is determined as the highest 30 second average of VO₂ during the exercise test. Respiratory exchange ratio (RER) is determined at the highest 30 second average for VO₂. RER's >1.1 are suggestive of a peak physiological effort. If a patient terminates the test prior to an RER>1.1, this will be documented and pre-to-post RER's will be compared to identify any significant variation that may occur. This test will also be conducted at the end of treatment (EOT), EOT+12 weeks and EOT+24 weeks to evaluate changes in fitness.

Nock N.L., Dimitropoulos A., Rao S.M., Flask C.A., Schluchter M., Zanotti K.M., Rose P.G., Kirwan J.P, & Alberts J. (2014). Rationale and Design of REWARD (Revving-Up Exercise for Sustained Weight Loss by Altering Neurological Reward and Drive): A Randomized Trial in Obese Endometrial Cancer Survivors. Contemporary clinical trials, 39(2), 236-245.

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Cardiopulmonary Assessment in Parkinson's

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Thirty-eight individuals with a diagnosis of idiopathic PD completed the informed consent process approved by the Cleveland Clinic Institutional Review Board. Primary inclusion criteria were clinical diagnosis of idiopathic PD by a neurologist, age between 30–75 years, and Hoehn and Yahr stages II-III when off antiparkinsonian medication. Primary exclusion criteria were existing cardiopulmonary disease or stroke, presence of dementia, and any medical or musculoskeletal contraindications to exercise. Participants completed a cardiopulmonary exercise (CPX) test on a stationary bicycle equipped with MedGraphics CardiO2/CP system with Breeze software and a twelve-lead electrocardiograph to screen for cardiac abnormalities that may warrant exclusion from the study.

Rosenfeldt A.B., Dey T, & Alberts J.L. (2016). Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson's Disease. Parkinson's Disease, 2016, 9725089.

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