Cobas integra 700

Manufactured by Roche

Sourced in Switzerland

The Cobas Integra 700 is a fully automated, random-access clinical chemistry analyzer. It is designed for high-throughput laboratory testing, providing accurate and reliable results for a wide range of clinical chemistry and immunochemistry assays.

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Lab products found in correlation

Dca vantage analyzer, by Siemens (1 mentions) Dca vantage analyser, by Siemens (1 mentions) Elecsys 2010, by Roche (1 mentions) Modular dpd biochemical system, by Roche (1 mentions) Cobas integra, by Roche (1 mentions) Rapidpoint 400, by Siemens (1 mentions)

Spelling variants of this product

Cobas Integra (65 citations) Cobas Integra 700/800 (13 citations) Integra 700 (4 citations) Cobas integra 400/700/800 (2 citations)

10 protocols using cobas integra 700

Detailed Diabetes Biomarker Assessment

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Diabetes duration was self-reported. Blood pressure was measured three times using a semi-automated blood pressure monitor, and the mean value was used. Fasting plasma glucose, HDL- and LDL-cholesterol and triacylglycerols were quantified by enzymatic methods (Roche Cobas Integra 700; Roche Diagnostics, Basel, Switzerland). HbA_1c was measured using a point-of-care analyser (DCA Vantage Analyzer; Siemens, Munich, Germany). Serum creatinine was measured using an enzymatic method, and GFR was estimated using the CKD-EPI equation [26 (link)]. Urinary albumin was quantified using an immunoturbidimetric assay (Roche Cobas c, Roche Diagnostics, Mannheim, Germany). Plasma C-reactive protein was quantified using an immunoassay kit (R&D Systems, Minneapolis, MN, USA). Fasting plasma C-peptide was measured using an ELISA kit (Mercodia, Uppsala, Sweden). Both intra- and inter-assay CVs were <5%. HOMA2-B (%) and HOMA2-IR were calculated based on fasting glucose and C-peptide (https://www.dtu.ox.ac.uk/homacalculator/, version 2.2.3).

Wang J., Liu J.J., Gurung R.L., Liu S., Lee J., M Y., Ang K., Shao Y.M., Tang J.I., Benke P.I., Torta F., Wenk M.R., Tavintharan S., Tang W.E., Sum C.F, & Lim S.C. (2022). Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes. Diabetologia, 65(12), 2146-2156.

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Cardiovascular Risk Factors in Diabetes

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Ethnicity, smoking status, and diabetes duration were self-reported. Information on medication usage at baseline was extracted from the medication dispensary database. History of atherosclerotic cardiovascular disease, including nonfatal myocardial infarction and stroke, was self-reported and cross-validated by reviewing medical records after cohort enrolment. HbA1c was measured by a point-of-care immunoassay analyser (DCA Vantage Analyser; Siemens, Munchen, Germany). Mean arterial pressure was calculated as.

Serum triacylglycerol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were measured by enzymatic methods (Roche Cobas Integra 700; Roche Diagnostics, Basel, Switzerland). Creatinine was quantified by an enzymatic method, which was traceable to the isotope dilution mass spectrometry reference. All eGFR readings in the current studies were estimated based on serum creatinine by the 2009 Chronic Kidney Disease-Epidemiology Collaboration formula [23 (link)]. Urine albumin was quantified by a solid-phase competitive chemiluminescent immunoassay (Immulite; DPC, Gwynedd, UK), and the albuminuria level was presented as the albumin-to-creatinine ratio (ACR, mg/g).

Gurung R.L., Liu S., Liu J.J., M. Y., Zheng H., Chan C., Ang K., Subramaniam T., Sum C.F, & Lim S.C. (2024). Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes. Cardiovascular Diabetology, 23, 70.

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Diagnosis of Iron Deficiency Anemia

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A hemoglobin levels of <13 g/dL in male subjects and <12 g/dL in female subjects were identified as IDA according to WHO criteria.¹⁴ The mean corpuscular volume (MCV) was <80 fL, the serum iron was <37 g/dL, and the serum ferritin was <13 ng/mL. Electro-chemiluminescence (Elec Sys 2010 analyzer; Roche Diagnostics, Mannheim, Germany) was used to evaluate serum ferritin levels, while a CobasIntegra700 analyzer was used to determine serum iron levels (Roche Diagnostics, Basel, Switzerland). The CBC assays were carried out on a SysmexSE-9000 automated analyzer (Kobe, Japan), which was calibrated regularly with the manufacturer’s standards.

Nasif W.A., Ali A.S., Alamodi H.S., Alrefai A.A., Alzubedi A.A., Almasoudi H.S., Sulaimani R.M., Sulaiman A.A, & Alharbi A.A. (2021). Impact of Helicobacter pylori on hematological parameters among Saudi population. Saudi Medical Journal, 42(6), 643-648.

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Automated Metabolic Profile Analysis

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Total cholesterol, LDL, HDL, triglycerides levels, and blood glucose level for all participants were determined by utilizing automated enzymatic analyzers (Cobas Integra 700; Hoffman-La Roche, Basel, Switzerland).

Ahmad A., Almsned F., Ghazal P., Ahmed M.W., Jafri M.S, & Bokhari H. (2020). Neuropeptide S receptor gene Asn107 polymorphism in obese male individuals in Pakistan. PLoS ONE, 15(12), e0243205.

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Seropositive vs. Seronegative Rheumatoid Arthritis

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The primary exposure was seropositive RA compared to seronegative RA. Seropositive RA was defined as either CCP or RF positivity (>upper limit of normal [ULN]) vs. seronegative (both CCP and RF negative, ≤ULN). These tests were performed at a CLIA-certified laboratory using commercial assays. Third-generation CCP measurements were performed using validated enzyme-linked immunosorbent assays (ELISAs) from Inova Diagnostics (San Diego, CA) and Euro-Diagnostica (Minneapolis, MN) with ULN of 19.9. RF measurements were performed by an immunoturbidimetric technique on the Cobas Integra 700 analyzer (Roche Diagnostics; Indianapolis, IN), using reagents and calibrators from Roche with ULN of 15. We defined CCP and RF levels as low positive (>1 to 3x ULN) or high positive (>3x ULN) based on cutoffs used in the 2010 ACR/EULAR criteria for RA classification[18 (link)].
We performed the following secondary analyses: 1) CCP positive vs. CCP negative (reference group); 2) RF positive vs. RF negative (reference group); 3) CCP high positive vs. CCP low positive vs. CCP negative (reference group); 4) RF high positive vs. RF low positive vs. RF negative (reference group); 5) CCP positive and RF positive vs. CCP positive and RF negative vs. CCP negative and RF positive vs. CCP negative and RF negative (reference group).

Huang S., He X., Doyle T.J., Zaccardelli A., Marshall A.A., Friedlander H.M., Blaustein R.B., Smith E.A., Cui J., Iannaccone C.K., Mahmoud T.G., Weinblatt M.E., Dellaripa P.F., Shadick N.A, & Sparks J.A. (2019). Association of rheumatoid arthritis-related autoantibodies with pulmonary function test abnormalities in a rheumatoid arthritis registry. Clinical rheumatology, 38(12), 3401-3412.

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Gut Microbiome Alterations in Pakistani Diabetics

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Blood samples were collected during the first quarter of 2017 from the diabetic clinic of the Social Security Hospital, Islamabad. All volunteers were interviewed and their age, gender, weight, ethnicity, diet, medical/drug history, fasting glucose level, lipid profile, smoking, physical activities, and alcohol intake was documented. Fasting blood glucose and lipid profile (triglycerides, total cholesterol, HDL, and LDL) were measured using an automated enzymatic analyzer (Cobas Integra 700; Hoffman-La Roche, Basel, Switzerland).
In general, adults aged 25–55 years, belonging to ethnic Punjabi (inhabitants of largest province) population of Pakistan, were included in the present study. Participants suffering from any symptoms of constipation, bloody stool, diarrhea, or any other gastrointestinal disease and those who were administered antibiotics (oral or injectable) in past three months, were excluded. All stool samples were collected within 24 h after compiling the questionnaire. Samples were collected in sterile containers provided to the volunteers and were stored at −80 °C. Sampling was performed using all standard protocols and regulation.

Ahmad A., Yang W., Chen G., Shafiq M., Javed S., Ali Zaidi S.S., Shahid R., Liu C, & Bokhari H. (2019). Analysis of gut microbiota of obese individuals with type 2 diabetes and healthy individuals. PLoS ONE, 14(12), e0226372.

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Venous Blood Sampling for Biochemical Analysis

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A venous blood sample for biochemical analyses was taken at the time of inclusion into the study, in all cases following a minimum of 8 hours fasting. The blood was maintained at room temperature (RT). For serum collection, blood samples are kept at RT for a minimum of 30 to a maximum of 60 min to allow a clot to form. The samples were then centrifuged at 4 °C, serum was distributed in aliquots and stored at −80 °C.
Glucose was determined in venous blood using the Modular DPD biochemical system (Roche Diagnostics). HbA1c was measured in the Cobas Integra 700 auto-analyzer (Roche Diagnostics) using an immunoturbidimetric method for completely haemolyzed, anti-coagulated blood. The laboratory reference range for healthy individuals was 4.5–5.7%. Lipid profiles, including total cholesterol (Total-chol), triglycerides (TG), LDL-cholesterol (LDL-chol) and HDL-cholesterol (HDL-chol) are quantified in the Modular DPD biochemical auto-analyzer using enzymatic colorimetry.

Pfeiffer S., Sánchez-Lechuga B., Donovan P., Halang L., Prehn J.H., Campos-Caro A., Byrne M.M, & López-Tinoco C. (2020). Circulating miR-330-3p in Late Pregnancy is Associated with Pregnancy Outcomes Among Lean Women with GDM. Scientific Reports, 10, 908.

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Insulin Resistance and Beta Cell Function Assessment in Children

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The children were fasted overnight for 10 h before venesection. The Homeostatic Model Assessment of Insulin Resistance (HOMA2IR) and the Homeostatic Model Assessment of Beta Cell Function (HOMA2B) were determined each year from fasting glucose (Cobas Integra 700 analyzer; Roche Diagnostics) and insulin (DPC IMMULITE) (cross-reactivity with proinsulin, 1%) using the homeostasis model assessment program, which has been validated in children (23 (link)).

Cominetti O., Hosking J., Jeffery A., Pinkney J, & Martin F.P. (2020). Contributions of Fat and Carbohydrate Metabolism to Glucose Homeostasis in Childhood Change With Age and Puberty: A 12-Years Cohort Study (EARLYBIRD 77). Frontiers in Nutrition, 7, 139.

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Carbamazepine Blood Concentration Measurement

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Patients’ carbamazepine blood concentration was tested at the central laboratory of the Hadassah University Hospital using fluorescence polarization with COBAS INTEGRA reagent system cassettes on COBAS INTEGRA 700 (Roche Diagnostics) [9 ] . The reagents, controls, and calibrators were obtained from Roche Diagnostics and were used according to the manufacturer’s instructions.

Hirsch A., Wanounou M., Perlman A., Hirsh-Raccah B, & Muszkat M. (2020). The effect of multidrug exposure on neurological manifestations in carbamazepine intoxication: a nested case-control study. BMC Pharmacology & Toxicology, 21, 47.

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Bovine Blood Calcium and Phosphate Dynamics

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Blood samples were collected from all the cows into vacuum tubes (Vacuette ® Serum Sep. Clot Activator, 5 ml, Greiner bio-one GmbH, Kremsmünster, Austria) immediately before treatment and 10, 20, 40, 60, 90 minutes and 2, 3, 4, 5, 6, 7, 8, 24, 48 and 72 hours after the beginning of treatment for the determination of the concentrations of total and ionised calcium, inorganic phosphate and magnesium. The concentrations of calcium, inorganic phosphate and magnesium were determined at 37 °C with a Cobas Integra 700 analyser (Roche Diagnostics, Rotkreuz), using Roche reagents under conditions defined by the International Federation of Clinical Chemists. The concentration of ionised calcium was measured using potentiometry (Rapidpoint 400, Siemens Healthcare, Zürich). Urine samples were tested for ketone bodies before the start of treatment.

Braun U., Grob D, & Hässig M. (2016). Treatment of cows with parturient paresis using intravenous calcium and oral sodium phosphate. Schweizer Archiv fur Tierheilkunde, 158(9).

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