FLZ was obtained as a gift from Aljazerah Pharmaceutical Company (Riyadh, Saudi Arabia). Hydroxypropyl methylcellulose low viscosity; viscosity of ~ 3 cP for 2% aqueous solution, MWT ~ 20,000 Da; (HPMC LV grade E3) was gained from Dow Chemical Co. (Midland, MI, USA). Kollicoat IR (KL) was obtained from BASF (Ludwigshafen, Germany). Pluronic F-127 (PL F127) was purchased from C.H. (Erbesloh, Krefeld, Germany). Xanthan gum (XG) was purchased from Sigma Chemical Co. (MO, USA). Polyvinyl pyrrolidone K30 (PVP; molecular weight 30,000 Da) was purchased from ISP Technologies, Inc. (NJ, USA). SLS was bought from Fisher Scientific International, Inc. (NH, USA). Carbopol 934 was obtained from Goodrich Chemical Co. (Poole, England). Sodium alginate was purchased from Sigma Chemical Co. (MO, USA). Standard dialysis cellophane membrane, molecular weight cut off ≈ 14,000 (Sigma chemical Co., MO, USA).The acetonitrile (HPLC–gradient) was purchased from Panreac (Madrid, Spain). Formic acid was purchased from Fisher Scientific (MA, USA).
Hydroxypropyl methylcellulose
Manufactured by Dow
Sourced in United States
Hydroxypropyl methylcellulose is a water-soluble cellulose derivative used as a thickening, suspending, and stabilizing agent in various laboratory applications. It is a white or off-white, odorless powder with a viscous, gel-like consistency when dissolved in water.
Automatically generated - may contain errors
3 protocols using hydroxypropyl methylcellulose
1
Formulation and Characterization of FLZ Delivery System
2
GBM Xenograft Survival Assay with AR42
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AR42 (Arno Therapeutics) was dissolved in dimethyl sulfoxide for in vitro treatments or in 0.5% hydroxypropyl methylcellulose (Dow Chemical Company)/0.1% Tween-80 (Sigma) for in vivo administration via oral gavage. On day 10 after injection of GBM cells, mice were administrated with AR42 for 9 days (three times per week, total 3 weeks), and Kaplan–Meier survival curves were generated.
3
Vinylidene Chloride Polymerization Protocol
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Vinylidene chloride (VDC, polymerization grade) was supplied by Juhua Group Co. (Hangzhou, China) and distilled twice in an atmosphere of N2. Acrylonitrile (AN, J&K Scientific Ltd., Beijing, China) and methyl methacrylate (MMA, Lingfeng Chemical, Shanghai, China) were distilled at reduced pressures. Divinyl benzene (DVB; m- and p-mixture, J&K Scientific Ltd., Beijing, China), 2,2′-azodiisobutyronitrile (AIBN), isopentane, pentane, hexane, heptanes, N, N-dimethylformamide, methanol, potassium dichromate, citric acid, and sodium chloride were chemically pure reagents and were purchased from Lingfeng Chemical (Shanghai, China). Hydroxypropyl methylcellulose and methylcellulose were supplied by Dow Chemical Co. (Midland, MI, USA). The deionized water was used for all experiments.
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