D mannitol

Manufactured by Roquette

Sourced in France

D-mannitol is a sugar alcohol that is commonly used as a pharmaceutical excipient in the production of tablets, capsules, and other drug formulations. It serves as a bulking agent, sweetener, and diluent in various pharmaceutical applications.

Automatically generated - may contain errors

Lab products found in correlation

Spelling variants of this product

Mannitol (14 citations)

7 protocols using d mannitol

Telmisartan Formulation Optimization Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols

TEL (514 g/mol, structure shown in Fig. 1), buffer components (NaH₂PO₄, NaOH, NaCl, KCl, HCl), sorbitol, sodium dodecyl sulfate (SDS), polyoxyethylene sorbitan monooleat (Tween 80), and n-dodecane were purchased from Sigma-Aldrich Co. Llc. (St. Louis, MO, USA). Lactose monohydrate was obtained from Meggle Pharma (Wasserburg, Germany). Reagent grade dichloromethane (DCM) and methanol (MeOH) were ordered from Merck Ltd. (Budapest, Hungary). D-mannitol and (2-Hydroxypropyl)-β-cyclodextrin (HPβCD), with the molar substitution degree of 0.64, were provided by Roquette Freres (Lestrem, France). Hydroxypropylmethylcellulose (HPMC 2910) was obtained from Aqualon, Hercules (Zwijndrecht, The Netherlands). Polyvinylpyrrolidone K30 and K90 (PVP K30 and K90) were received from BASF (Ludwigshafen, Germany). Hydroxypropylmethylcellulose acetate succinate (HPMC-AS) polymer was provided by Ashland Inc. (Wilmington, USA). Prisma^HT buffer were obtained from Pion Inc. (Billerica, MA, USA). Simulated intestinal fluid (SIF) powder was purchased from Biorelevant.com (London, UK). Telmisartan brand tablets (Micardis 40 mg API/tablet) were purchased from Boehringer Ingelheim International Gmbh (Ingelheim am Rhein, Germany).
Figure 1

Structure of telmisartan

Kádár S., Tőzsér P., Nagy B., Farkas A., Nagy Z.K., Tsinman O., Tsinman K., Csicsák D., Völgyi G., Takács-Novák K., Borbás E, & Sinkó B. (2022). Flux-Based Formulation Development—A Proof of Concept Study. The AAPS Journal, 24(1), 22.

+ Open protocol

+ Expand

Reagent Acquisition for Biochemical Assays

Check if the same lab product or an alternative is used in the 5 most similar protocols

The 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), ascorbic acid, crocin, D-(+)-dihydrate trehalose, dimethyl sulfoxide (DMSO), glutaraldehyde, and L-glutamine 200 mM were purchased from Sigma-Aldrich (Merck KGaA, Darmstadt, Germany). D-mannitol was bought from Roquette (Roquette Frères, Lestrem, France).

Perteghella S., Rassu G., Gavini E., Obinu A., Bari E., Mandracchia D., Bonferoni M.C., Giunchedi P, & Torre M.L. (2021). Crocetin as New Cross-Linker for Bioactive Sericin Nanoparticles. Pharmaceutics, 13(5), 680.

+ Open protocol

+ Expand

Pregabalin Formulation and Evaluation

Check if the same lab product or an alternative is used in the 5 most similar protocols

Pregabalin was purchased from MSN Pharmachem (India). PEO (Polyox WSR 303) was purchased from Dow Chemical. Microcrystalline cellulose (MCC, Vivapur^® 12) was purchased from JRS Pharma (Germany), povidone (Kollidon^® 90F) from BASF (Germany), L-tartaric acid from Caviro (Italy), and D-mannitol from Roquette. All other excipients used were of pharmaceutical grade. All reagents used in the analyses were of analytical grade. An IR formulation (Lyrica Capsules, Pfizer) was used as a reference drug for pharmacokinetic studies.

Kim K.H., Lim S.H., Shim C.R., Park J., Song W.H., Kwon M.C., Lee J.H., Park J.S, & Choi H.G. (2020). Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans. Drug Design, Development and Therapy, 14, 445-456.

+ Open protocol

+ Expand

Rabeprazole Sodium Tablet Formulation

Check if the same lab product or an alternative is used in the 5 most similar protocols

The active pharmaceutical ingredient (API) rabeprazole sodium was purchased from Ildong (Seoul, Korea), while sodium bicarbonate was purchased from Hebei Huachen Pharmaceutical Co. Ltd. (Huanghua, Hebei, China). Additionally, the following reagents were used throughout the study: D-mannitol (Roquette, Lestrem, France), heavy calcium carbonate (Shanghai Nuocheng Pharmaceutical Co. Ltd., Shanghai, China), magnesium oxide (Tomita Pharmaceutical Co. Ltd., Tokushima, Japan), calcium hydroxide (Spectrum Pharmaceuticals, Henderson, NV, USA), hydroxypropyl cellulose (Nippon Soda Co. Ltd., Tokyo, Japan), sodium starch glycolate (JRS Pharma, Rosenberg, Germany), low-substituted hydroxypropyl cellulose and ethylcellulose (Ashland, Covington, KY, USA), magnesium stearate (Faci Asia Pacific Pty Ltd., Jurong Island, Singapore), talc (Nippon Talc Co. Ltd., Osaka, Japan), titanium dioxide (Huntsman Corporation, Oulsburg, Germany), aluminum lake yellow No. 4 (Borak, Hwaseong, Gyeonggi, Korea), as well as copovidone and crospovidone (BASF Co. Ltd., Ludwigshafen, Germany). All other chemicals were of analytical reagent grade and purchased commercially.

Lee S.H, & Kim J.E. (2021). Quality by Design Applied Development of Immediate-Release Rabeprazole Sodium Dry-Coated Tablet. Pharmaceutics, 13(2), 259.

+ Open protocol

+ Expand

Formulation and Evaluation of a Gastro-Resistant Drug Delivery System

Check if the same lab product or an alternative is used in the 5 most similar protocols

EMP was a gift from Lee Pharma Limited (Hyderabad, India). D-mannitol was provided by Roquette (Lesterem, Singapore). Low-substituted hydroxypropyl cellulose (L-HPC) and hypromellose (HPMC) 2910 were purchased from Shin-Etsu (Tokyo, Japan). Croscarmellose sodium (CMC-Na) was obtained from DuPont Nutrition (Newark, DE, USA). HPC L-type (HPC-L) was supplied by Nippon Soda Co., Ltd. (Tokyo, Japan). Sodium stearyl fumarate (SSF) was purchased from JRS Pharma (Polanco, Spain). Talc was purchased from Merck (Darmstadt, Germany). Triethyl citrate (TEC) was purchased from MORIMURA Bros., INC. (Tokyo, Japan). Glycerol monostearate (GMS) was obtained from Gattefosse (Saint-Priest, France). Polysorbate 80 was purchased from CRODA (Seraya, Singapore). Iron oxide red was obtained from VENATOR (Turin, Italy). ELD-55, ES-100, and EL-100 were obtained from Evonik Industries (Darmstadt, Germany). Hard capsules (HPMC) were obtained from SUHEUNG Co., Ltd. (Cheongju, Korea). A commercial product (Nexium^® tablet; 40 mg) was purchased from AstraZeneca Korea Co. (Seoul, Korea). All other reagents were of reagent grade and used without further purification.

Kwon T.K., Kang J.H., Na S.B., Kim J.H., Kim Y.I., Kim D.W, & Park C.W. (2022). Novel Esomeprazole Magnesium-Loaded Dual-Release Mini-Tablet Polycap: Formulation, Optimization, Characterization, and In Vivo Evaluation in Beagle Dogs. Pharmaceutics, 14(7), 1411.

+ Open protocol

+ Expand

Formulation and Coating of D-Mannitol Tablets

Check if the same lab product or an alternative is used in the 5 most similar protocols

Materials The tablet cores were prepared using D-mannitol (Roquette, Lestrem, France), microcrystalline cellulose (Asahi Kasei Chemicals, Tokyo, Japan), crospovidone (BASF, Ludwigshafen, Germany) and magnesium stearate (Merck KGaA, Darmstadt, Germany). The composition of each tablet core was as follows: D-mannitol 64% (w/w), microcrystalline cellulose 30% (w/w), crospovidone 5% (w/w) and magnesium stearate 1% (w/w). D-mannitol, microcrystalline cellulose and crospovidone were initially blended in a container mixer before being blended with magnesium stearate in the same container. The blended powder was subsequently compressed on a compression machine (HT-X20, Hata Iron Works, Kyoto, Japan) using 8 mm biconcave punches to form the core tablets. Opadry ® Yellow (Colorcon, Shizuoka, Japan) containing hypromellose, polyethylene glycol, titanium oxide, talc and yellow ferric oxide was used as the film coating agent by dispersing in water at a concentration of 10% (w/w).
Equipment The film coating process was performed on a pilot scale with 33 kg of the core tablets charged into the film coater system (Powrex, Hyogo, Japan).
Film Coating The core tablets were coated with 3% (w/w) Opadry ® Yellow by spraying the tablets with a dispersion of the coating. Three batches of film coated tablets were manufactured under the conditions shown in Table 4.

Yoshino H., Yamashita K., Iwao Y., Noguchi S, & Itai S. (2016). Quantitative Appearance Inspection for Film Coated Tablets. Chemical & pharmaceutical bulletin, 64(8).

+ Open protocol

+ Expand

Pemetrexed Disodium Hemipentahydrate Formulation

Check if the same lab product or an alternative is used in the 5 most similar protocols

Pemetrexed disodium hemipentahydrate was purchased from Nippon Kayaku (Tokyo, Japan). d-mannitol was obtained from Roquette (Corby, UK). Hydrochloric acid (HCl), sodium hydroxide (NaOH), hydrogen peroxide, potassium dihydrogen phosphate, ortho-phosphoric acid (PA), sodium carbonate, sodium bicarbonate, sodium formaldehyde bisulfite, sodium sulfate, and sodium sulfite were purchased from Merck (Darmstadt, Germany). The pemetrexed-related substances, α-hydroxy lactams, keto-pemetrexed, oxidative dimers, and ring-opened keto-amide were obtained from TRC (Toronto, ON, Canada). N-acetylcysteine (NAC, Kyowa Hakko Bio Co., Ltd., Tokyo, Japan), l-cysteine·HCl, sodium sulfide, and sodium metabisulfite were purchased from Sigma Aldrich (Saint Louis, MO, USA). Hydroxypropyl-β-cyclodextrin (Kleptose^® HPB, Roquette-Freres, Lestrem CEDEX, France) and d-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS, Eastman Chemical Co., Kingsport, TN, USA) were also utilized. Acetonitrile and acetone were obtained from Fisher Scientific (Pittsburgh, PA, USA). All other chemicals were of reagent grade and used without further purification.

Won D.H., Park H., Ha E.S., Kim Y.M., Hwang H.D., Jang S.W, & Kim M.S. (2020). Effect of Formulation Factors and Oxygen Levels on the Stability of Aqueous Injectable Solution Containing Pemetrexed. Pharmaceutics, 12(1), 46.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!