Tariquidar

Manufactured by Adooq

Sourced in United States

Tariquidar is a laboratory compound used in research. It functions as a P-glycoprotein inhibitor.

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Lab products found in correlation

Paclitaxel, by Fujifilm (1 mentions) Vinblastine, by Fujifilm (1 mentions) Doxorubicin, by Fujifilm (1 mentions) Cisplatin, by Fujifilm (1 mentions) Rhodamine 123, by Fujifilm (1 mentions) 125i iodoarylazidoprazosin iaap, by PerkinElmer (1 mentions) Cyclosporin a, by Merck Group (1 mentions) Calcein am, by Merck Group (1 mentions) Celltiter 96 aqueous one solution reagent, by Promega (1 mentions) 1 palmitoyl 2 oleoyl sn glycero 3 phosphocholine, by Avanti Polar Lipids (1 mentions) 1 palmitoyl 2 oleoyl sn glycero 3 phosphoethanolamine, by Avanti Polar Lipids (1 mentions) 1 palmitoyl 2 oleoyl sn glycero 3 phospho l serine, by Avanti Polar Lipids (1 mentions) Nadolol, by Merck Group (1 mentions) Dexamethasone (dex), by Nacalai Tesque (1 mentions) Metoprolol tartrate, by Tokyo Chemical Industry (1 mentions) Atenolol, by Tokyo Chemical Industry (1 mentions) Rhodamine 123, by Merck Group (1 mentions) Temocaprilat, by LGC (1 mentions)

3 protocols using tariquidar

Evaluating Drug Transport Inhibitors

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Calcein AM and cyclosporin A were obtained from Sigma-Aldrich (St. Louis, MO). Rhodamine 123, paclitaxel, vinblastine, doxorubicin, and cisplatin were purchased from Wako (Tokyo, Japan). Tariquidar was purchased from AdooQ BioScience (Irvine, CA). CellTiter 96 AQueous One Solution Reagent was purchased from Promega (Madison, WI). [¹²⁵I]-Iodoarylazidoprazosin (IAAP) was obtained from Perkin-Elmer Life Science (Wellesley, MA).

Sugisawa N., Ohnuma S., Ueda H., Murakami M., Sugiyama K., Ohsawa K., Kano K., Tokuyama H., Doi T., Aoki J., Ishida M., Kudoh K., Naitoh T., Ambudkar S.V, & Unno M. (2018). A novel potent ABCB1 modulator, phenethylisoquinoline alkaloid, reverses multidrug resistance in cancer cell. Molecular pharmaceutics, 15(9), 4021-4030.

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Characterization of P-glycoprotein modulators

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The lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS) were acquired from Avanti Polar Lipids, Inc. (Alabaster, AL, USA). [¹²⁵I] Iodoarylazidoprazosin (IAAP) 1100 Ci/mmol) was purchased from PerkinElmer Life Sciences (Wellesley, MA, USA), and Tariquidar was purchased from AdooQ BioScience (Irvine, CA, USA). The fluorescent NBD amphiphiles were synthesized and purified, as previously reported by us [41 (link),42 (link)], and the products were stored at −20 °C in the dry state or dissolved in DMSO. The concentration of the NBD–amphiphiles was calculated from their absorption at the maxima (≅466 nm, ε = 2.1 × 10⁴) [41 (link),42 (link)]. Reagents and solvents used were analytical grade or with higher purity, and water was distilled and further deionized with a final resistance ≥ 18 MΩ.
The structures and common molecular descriptors of the P–gp modulators characterized experimentally in this work are shown in Table 1.

Moreno M.J., Filipe H.A., Cunha S.V., Ramos C.V., Martins P.A., Abel B., Loura L.M, & Ambudkar S.V. (2023). Interaction of a Homologous Series of Amphiphiles with P-glycoprotein in a Membrane Environment—Contributions of Polar and Non-Polar Interactions. Pharmaceutics, 15(1), 174.

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Evaluation of Drug Transport Inhibitors

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Materials Propranolol hydrochloride, dexamethasone, and bis-p-nitrophenyl phosphate (BNPP) were obtained from Nacalai Tesque, Inc. (Kyoto, Japan). Metoprolol tartrate, atenolol, and acyclovir were obtained from Tokyo Chemical Industry Co., Ltd. (Tokyo, Japan). Nadolol and rhodamine 123 were obtained from Sigma-Aldrich Co. (St. Louis, MO, U.S.A.). Tariquidar was obtained from AdooQ BioScience (Irvine, CA, U.S.A.). Temocapril hydrochloride and temocaprilat were obtained from Toronto Research Chemicals, Inc. (North York, ON, Canada). All other chemicals were of the highest available purity.

Sasaki Y., Tatsuoka H., Tsuda M., Sumi T., Eguchi Y., So K., Higuchi Y., Takayama K., Torisawa Y, & Yamashita F. (2022). Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices. Biological & pharmaceutical bulletin, 45(9).

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