R sch 23390

Manufactured by Merck Group

Sourced in United States

R(+)-SCH-23390 is a selective dopamine D1 receptor antagonist compound. It has a molecular formula of C17H16ClNO and a molecular weight of 301.78 g/mol. R(+)-SCH-23390 is commonly used in research applications to study the role of dopamine D1 receptors in various biological processes.

Automatically generated - may contain errors

Lab products found in correlation

Spelling variants of this product

R(+)-SCH-23390 hydrochloride (36 citations)

5 protocols using r sch 23390

Neuromodulatory Compounds Administration

Check if the same lab product or an alternative is used in the 5 most similar protocols

Nicotine hydrogen tartrate, haloperidol, and R-(±) SCH-23390 were
purchased from Sigma-Aldrich (St. Louis, MO, USA). The nicotine and SCH-23390
for systemic administration was dissolved in 0.9% sterile saline
(Hospira Inc, Lake Forest, IL, USA). haloperidol and SCH-23390 for local
infusion were dissolved in artificial cerebrospinal fluid (aCSF), which served
as the vehicle for both compounds.

Hall B.J., Slade S., Allenby C., Kutlu M.G, & Levin E.D. (2015). Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. Neuropharmacology, 99, 689-695.

+ Open protocol

+ Expand

Pharmacological Characterization of Compounds

Check if the same lab product or an alternative is used in the 5 most similar protocols

The following compounds were used in this study (obtained from the sources indicated): CFA (catalog # F5881; Sigma-Aldrich Co., Toluca, Mexico); mazindol (a gift from MEDIX Pharmaceutical, Mexico City, Mexico); haloperidol (D2-like receptor antagonist, catalog # H1512; Sigma-Aldrich); naloxone (opioid receptor antagonist, catalog # N7758; Sigma-Aldrich); and R(+)-SCH 23390 (D1-like receptor antagonist, catalog # D054-5MG; Sigma-Aldrich Co.). Mazindol was dissolved in 0.025% carboxymethyl cellulose (CMC). Other drugs were dissolved in saline solution.

Robledo-González L., Martínez-Martínez A., Vargas-Muñoz V., Acosta-González R., Plancarte-Sánchez R., Anaya-Reyes M., Fernández del Valle-Laisequilla C., Reyes-García J, & Jiménez-Andrade J. (2017). Repeated administration of mazindol reduces spontaneous pain-related behaviors without modifying bone density and microarchitecture in a mouse model of complete Freund’s adjuvant-induced knee arthritis. Journal of Pain Research, 10, 1777-1786.

+ Open protocol

+ Expand

Artificial Cerebrospinal Fluid Composition

Check if the same lab product or an alternative is used in the 5 most similar protocols

The artificial cerebrospinal fluid (aCSF) consisted of 120 mM NaCl, 4.8 mM KCl, 1.2 mM KH₂PO₄, 1.2 mM MgSO₄, 25 mM NaHCO₃, 2.5 mM CaCl, 10 mM d-glucose, pH 7.2–7.4. Ethyl alcohol (190 proof) was obtained from McCormick Distilling, Weston, MO. The dopamine D₂ receptor antagonist (−)-sulpiride and the D₁ receptor antagonist R(+)-SCH23390 were purchased from Sigma-Aldrich (St. Louis, MO). All chemicals were dissolved in the aCSF solution to the desired concentrations.

Ding Z.M., Ingraham C.M., Rodd Z.A, & McBride W.J. (2014). The reinforcing effects of ethanol within the posterior ventral tegmental area depend upon dopamine neurotransmission to forebrain cortico-limbic systems. Addiction biology, 20(3), 458-468.

+ Open protocol

+ Expand

Neurochemical Modulation Experimental Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols

NMDA, butaclamol ((+)-butaclamol hydrochloride), and SCH23390 (R(+)-SCH-23390) were purchased from Sigma-Aldrich (Missouri, USA). DA (3,4-dihydroxyphenethylamine hydrochloride) was purchased from Wako Pure Chemical Industries (Osaka, Japan). Papain was purchased from Worthington Biochemical Corporation (New Jersey, USA). butaclamol was dissolved in DMSO, and NMDA, SCH23390 and DA were dissolved in water.

Ueno K., Suzuki E., Naganos S., Ofusa K., Horiuchi J, & Saitoe M. (2017). Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies. eLife, 6, e21076.

+ Open protocol

+ Expand

Chlorpromazine Hydrochloride Pharmacology in Mice

Check if the same lab product or an alternative is used in the 5 most similar protocols

Chlorpromazine hydrochloride (CPZ, 25 mg/ml injectable blister, #50-53-3; Duncan Laboratory AS, Argentina) was donated by Dr. Martinez Mónaco and Dr. Pinedo (Italian Hospital of La Plata, Buenos Aires, Argentina) and stored at 4 C, protected from light. Chlorpromazine working solutions were prepared fresh on experimental days, using sterile milli-Q water (for pre-incubations of transfected HEK293T cells), arti cial cerebrospinal uid (aCSF (detailed composition below), for intra-mPFC injections in mice) or sterile saline (0.9 % NaCl, for intraperitoneal (IP) injections in mice). Additionally, the following drugs were used as indicated for each experiment: the sodium channel blocker tetrodotoxin (TTX, #4368-28-9, Sigma-Aldrich, USA), the sodium channel blocker lidocaine N-ethyl bromide (QX-314, #552233, Calbiochem, USA), the Ca V 1 blocker nifedipine (#N-7634, Sigma-Aldrich, USA), the Ca V 2.1 blocker ω-agatoxin IVA (#145017-83-0, Alomone Labs, Israel), the Ca V 2.2 blocker ω-conotoxin GVIA (#106375-28-4, Alomone Labs, Israel), nickel (II) chloride hexahydrate (NiCl 2 , #2000979900, Biopack Analytical Systems AS, Argentina), dopamine hydrochloride (#62-31-7, Sigma-Aldrich, USA), the D1R-like antagonist R(+)-SCH-23390 (#125941-87-9, Sigma-Aldrich, USA) and the D1R-like agonist (±)-SKF-38393 hydrochloride (#62717-42-4, Sigma-Aldrich, USA).

McCarthy C.I., Mustafá E.R., Cornejo M.P., Yaneff A., Rodríguez S.S., Perello M, & Raingo J. (2023). Chlorpromazine, an Inverse Agonist of D1R-Like, Differentially Targets Voltage-Gated Calcium Channel (Ca_V) Subtypes in mPFC Neurons. Molecular neurobiology, 60(5).

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!