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Winnonlin professional 4

Manufactured by Pharsight
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Sourced in United States

WinNonlin Professional 4.0.1 is a software application designed for pharmacokinetic and pharmacodynamic data analysis. It provides tools for modeling, simulation, and visualization of drug concentration and response data.

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WinNonLin professional version 4.1 WinNonlin Professional WinNonlin 4.1 WinNonlin

4 protocols using winnonlin professional 4

1

Rabbit Pharmacokinetic Analysis

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Plasma concentration–time curves were constructed and the pharmacokinetic parameters [namely: Cmax (µg/mL), Tmax (hour), AUC0–4, and AUC0–∞ (μg⋅h/mL), K (hour−1), and t1/2 (hour)] for each rabbit were calculated and manipulated using WinNonlin Professional 4.0.1 software (Pharsight Corp., Cary, NC, USA).
Genedy S., Khames A., Hussein A, & Sarhan H. (2018). Hydralazine HCl rapidly disintegrating sublingual tablets: simple dosage form of higher bioavailability and enhanced clinical efficacy for potential rapid control on hypertensive preeclampsia. Drug Design, Development and Therapy, 12, 3753-3766.
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2

Pharmacokinetic Analysis of Rabbit Plasma

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Plasma concentration–time curves were constructed, and the pharmacokinetic parameters [namely Cmax (μg/mL), Tmax (hour, h), AUC0–8 and AUC0–∞ (μg.h/mL), Kel (hour−1, h−1), and t1/2 (hour, h)] for each rabbit were calculated and manipulated using WinNonlin Professional 4.0.1 software (Pharsight Corp., Cary, NC, USA).
, & Khames A. (2019). Hexyl alginate derivative, an amphiphilic innovative buccal film-forming material of promising mechanical and release characteristics for the improvement of repaglinide bioavailability. Drug Design, Development and Therapy, 13, 925-940.
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3

Rabbit Pharmacokinetic Analysis

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Plasma concentration time curves were constructed and the data were manipulated using WinNonlin Professional 4.0.1 software (Pharsight Corp., Cary, NC, USA), followed by calculation of pharmacokinetic parameters (Cmax (ng/mL), Tmax (hour), AUC0–24 and AUC0–∞ (ng·hour/mL, Kel (hours−1), and t1/2 (hours)) for each rabbit.
, & Khames A. (2019). Formulation and Characterization of Eplerenone Nanoemulsion Liquisolids, An Oral Delivery System with Higher Release Rate and Improved Bioavailability. Pharmaceutics, 11(1), 40.
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4

Rabbit Pharmacokinetic Analysis

Check if the same lab product or an alternative is used in the 5 most similar protocols
Plasma concentration-time curves were constructed and the pharmacokinetic parameters [namely: Cpmax (μg/mL), Tmax (h), AUC0–24 and AUC0–∞ (μg h/mL), Kel (h−1) and t1/2 (h)] for each rabbit were calculated and manipulated using WinNonlin Professional 4.0.1 software (Pharsight Corp., Cary, NC).
, & Khames A. (2017). Investigation of the effect of solubility increase at the main absorption site on bioavailability of BCS class II drug (risperidone) using liquisolid technique. Drug Delivery, 24(1), 328-338.
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