Benzbromarone

Manufactured by Bio-Techne

Sourced in United States

Benzbromarone is a laboratory reagent used in biochemistry and pharmaceutical research. It is a uricosuric agent, which means it helps increase the excretion of uric acid from the body. Benzbromarone is commonly used in the study of uric acid metabolism and the development of treatments for conditions related to uric acid, such as gout.

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Lab products found in correlation

Thapsigargin, by Bio-Techne (1 mentions) Tetrodotoxin ttx, by Bio-Techne (1 mentions) Gsk 7975a, by Aobious (1 mentions) Bumetanide, by Bio-Techne (1 mentions) Isradipine, by Bio-Techne (1 mentions) Nicardipine, by Merck Group (1 mentions) Furosemide, by Bio-Techne (1 mentions) Caccinh a01, by Bio-Techne (1 mentions) Zd7288, by Bio-Techne (1 mentions)

2 protocols using benzbromarone

Pharmacological Inhibitors of Cellular Signaling

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Tetrodotoxin (TTX), 2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl) methylideneamino]-acetamide (Ani-9), Benzbromarone, Nω-nitro-L-arginine (L-NNA), 1H-[1,2,4] Oxadiazolo [4,3-a] quinoxalin-1-one (ODQ), and Thapsigargin were purchased from Tocris Bioscience (Ellisville, Missouri, USA). GSK 7975 A was purchased from Aobious (Gloucester, MA).

Drumm B.T., Rembetski B.E., Baker S.A, & Sanders K.M. (2019). Tonic inhibition of murine proximal colon is due to nitrergic suppression of Ca2+ signaling in interstitial cells of Cajal. Scientific Reports, 9, 4402.

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Preparation and Use of Ionic Solutions

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CaCC_inh-A01 (Tocris), benzbromarone (Tocris), nicardipine (Sigma), TTA-A2 (Alamone), and isradipine (Tocris) were dissolved in DMSO (concentration of DMSO in solution did not exceed 0.01%). ZD7288 (Tocris) was dissolved in water. Furosemide (Tocris) and bumetanide (Tocris) were dissolved in 100% ethanol (ethanol concentration did not exceed 0.01%). Nominal Ca²⁺ solutions (0 mM Ca²⁺ + 1 mM EGTA) contained (in mM): 120.35 NaCl 5.9 KCl, 15.5 NaHCO₃, 1.2 Na₂HPO₄, 1.2 MgCl₂, 11.5 glucose, 2.5 MgCl₂, and 1.0 EGTA.

Grainger N., Shonnard C.C., Quiggle S.K., Fox E.B., Presley H., Daugherty R., Shonnard M.C., Drumm B.T, & Sanders K.M. (2022). Propagation of Pacemaker Activity and Peristaltic Contractions in the Mouse Renal Pelvis Rely on Ca2+-activated Cl− Channels and T-Type Ca2+ Channels. Function, 3(6), zqac041.

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