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Methocel e3lv

Manufactured by Dow
Sourced in United States

Methocel E3LV is a cellulose-based product used as a thickening, suspending, and stabilizing agent in various formulations. It is a water-soluble, non-ionic cellulose ether with a low viscosity.

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4 protocols using methocel e3lv

1

Foam Stability of Polymer Solutions

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Example 12

Solutions of concentration 1000 ppm w/v of poly(propylene glycol) with Mn 1000 (PPG1000, Sigma Aldrich, St. Louis, Mo.), poly(2-ethyl-2-oxazoline) with Mn 5000 and PDI≤1.2 (POX5000, Sigma Aldrich, St. Louis, Mo.), Methocel E3LV (Dow Chemical Company, Midland, Mich.), polysorbate 80 (PS80, Sigma Aldrich, St. Louis, Mo.), and Pluronic F68 (F68, BASF Corporation) were prepared using ultrapure deionized water (18.2 MΩ·cm at 25° C.). 3 mL of each solution was placed into a 5-mL polypropylene tube and vortexed on a Mini Vortex Mixer (VWR, Radnor, Pa.) on mixer setting #8 for 15 seconds. The foam heights were measured after vortexing and are listed in Table 20. The times for the foams to dissipate were also recorded and are listed in Table 20. The foams for the POX5000 and F68 samples did not dissipate over the course of the experiment. The stopping points are listed in Table 20.

TABLE 20
ExcipientFoam height (in)Foam dissipation time (s)
PPG10000.254
POX50000.6327
Methocel E3LV1.00>1125
PS800.257
F681.25>1125

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2

Foam Stability of Polymer Solutions

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Example 12

Solutions of concentration 1000 ppm w/v of poly(propylene glycol) with Mn 1000 (PPG1000, Sigma Aldrich, St. Louis, Mo.), poly(2-ethyl-2-oxazoline) with Mn 5000 and PDI≤1.2 (POX5000, Sigma Aldrich, St. Louis, Mo.), Methocel E3LV (Dow Chemical Company, Midland, Mich.), polysorbate 80 (PS80, Sigma Aldrich, St. Louis, Mo.), and Pluronic F68 (F68, BASF Corporation) were prepared using ultrapure deionized water (18.2 MΩ·cm at 25° C.). 3 mL of each solution was placed into a 5-mL polypropylene tube and vortexed on a Mini Vortex Mixer (VWR, Radnor, Pa.) on mixer setting #8 for 15 seconds. The foam heights were measured after vortexing and are listed in Table 20. The times for the foams to dissipate were also recorded and are listed in Table 20. The foams for the POX5000 and F68 samples did not dissipate over the course of the experiment. The stopping points are listed in Table 20.

TABLE 20
ExcipientFoam height (in)Foam dissipation time (s)
PPG10000.254
POX50000.6327
Methocel E3LV1.00>1125
PS800.257
F681.25>1125

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3

Foam Characterization of Polymeric Excipients

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Example 12

Solutions of concentration 1000 ppm w/v of poly(propylene glycol) with Mn 1000 (PPG1000, Sigma Aldrich, St. Louis, Mo.), poly(2-ethyl-2-oxazoline) with Mn 5000 and PDI ≤1.2 (POX5000, Sigma Aldrich, St. Louis, Mo.), Methocel E3LV (Dow Chemical Company, Midland, Mich.), polysorbate 80 (PS80, Sigma Aldrich, St. Louis, Mo.), and Pluronic F68 (F68, BASF Corporation) were prepared using ultrapure deionized water (18.2 MΩ·cm at 25° C.). 3 mL of each solution was placed into a 5-mL polypropylene tube and vortexed on a Mini Vortex Mixer (VWR, Radnor, Pa.) on mixer setting #8 for 15 seconds. The foam heights were measured after vortexing and are listed in Table 20. The times for the foams to dissipate were also recorded and are listed in Table 20. The foams for the POX5000 and F68 samples did not dissipate over the course of the experiment. The stopping points are listed in Table 20.

TABLE 20
ExcipientFoam height (in)Foam dissipation time (s)
PPG10000.254
POX50000.6327
Methocel E3LV1.00>1125
PS800.257
F681.25>1125

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4

HPMC and HPC Polymers: Physicochemical Characterization

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The hydroxypropylmethylcelluloses (HPMC) of substitution type 2910 (Methocel E3 LV) and 2208 (Methocel K100 M), of viscosity 3 mPa s and 100,000 mPa s respectively, were provided by Dow Chemical (Michigan, USA). In the nomenclature of HPMC grades, an initial letters K and E identifies contents of methoxy groups of about 19–24% and 28–30% respectively. The number following the letter identifies the viscosities of that grade measured at 2% concentration in water at 20°C. The letter “M” is used to represent 1000 while “LV” refers to low viscosity. Investigated Klucel® Pharm hydroxypropyl celluloses types LF, MF, and HF were kindly provided by Hercules Incorporated, Aqualon Division. The physicochemical properties of polymers under study are presented in Table I.

Physicochemical properties of Klucel® Pharm hydroxypropyl celluloses (HPC) LF, MF, and hydroxypropyl methylcelluloses (HPMC) Methocels E3 LV and K100M

HPMC typeType of substitutionMethoxy groups [%]Hydroxypropoxy groups [%]Viscosity [cP](at solution concentration %)
Methocel E3 LV291028.0–30.07–123 (2%)
Methocel K100M220819.0–24.07–12100,000 (2%)
HPC typeMolecular massMoles of substitutionHydroxypropoxy groups [%]

Viscosity [cP]

(at solution concentration %)

LF95,0003.672.8126 (5%)
MF850,0003.874.86300 (2%)
Acetonitrile AR (POCh Gliwice) and formic acid AR (J.T. Baker) were analytical grade and commercially available.
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