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Sterile water

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Sterile water is a laboratory-grade water that has been purified and sterilized to remove impurities, microorganisms, and other contaminants. It is primarily used as a diluent or solvent in various laboratory procedures, ensuring the purity and consistency of sample preparations.

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Sterile water for Injection (3 citations)

3 protocols using sterile water

1

SIV/HIV DNA Vaccine Immunogenicity

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The macaques received SIV gag DNA and SIV or HIV env DNA as indicated in Table 1. All DNA vaccine mixtures contained 0.1 μg of macaque IL-12 DNA and were formulated in 0.6 ml of sterile water (Hospira, Inc.., Lake Forest, IL). The DNA vaccine mixtures were delivered via intramuscular (IM) injection at 2 different sites (0.3 ml each site) followed by in vivo electroporation using the Elgen 1000 device (Inovio, Pharmaceuticals, Inc., Blue Bell, PA) as reported previously.43 (link) Blood was collected 2 weeks after the 2nd vaccination. SIV/HIV-specific cellular immune responses were measured in PBMC and humoral responses were measured in the plasma.
Valentin A., Li J., Rosati M., Kulkarni V., Patel V., Jalah R., Alicea C., Reed S., Sardesai N., Berkower I., Pavlakis G.N, & Felber B.K. (2015). Dose-dependent inhibition of Gag cellular immunity by Env in SIV/HIV DNA vaccinated macaques. Human Vaccines & Immunotherapeutics, 11(8), 2005-2011.
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2

Rhesus Macaque DNA.HTI Vaccination

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Indian rhesus macaques (R678, R679, R680, R681) were vaccinated with 2 mg of DNA.HTI together with 0.2 μg of macaque IL-12 DNA formulated in 0.6 ml of sterile water (Hospira, Inc., Lake Forest, IL). DNAs were delivered via intramuscular (IM) injection at two different sites (0.3 ml each site) followed by in vivo electroporation using the Elgen 1000 device (Inovio, Pharmaceuticals, Inc, Blue Bell, PA). The animals received three vaccinations with DNA.HTI at 0, 1 and 3 month. After a rest period of 4.5 months, the animals received a boost with recombinant MVA.HTI (108 pfu/dose) delivered via the IM route as a single inoculation. A 2nd MVA.HTI boost was administered 3 months later. All macaques used in this study were males and were 3 years of age at the onset of the study. Vaccinations were performed under anesthesia (Ketamine administered at 10 mg/kg) and all efforts were made to minimize suffering. No adverse effects were found. None of the animals were euthanized as part of this study.
Mothe B., Hu X., Llano A., Rosati M., Olvera A., Kulkarni V., Valentin A., Alicea C., Pilkington G.R., Sardesai N.Y., Rocafort M., Crespo M., Carrillo J., Marco A., Mullins J.I., Dorrell L., Hanke T., Clotet B., Pavlakis G.N., Felber B.K, & Brander C. (2015). A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques. Journal of Translational Medicine, 13, 60.
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3

Locomotor Effects of Psychostimulants in Mice

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Psychostimulant-induced locomotion following cocaine or amphetamine (AMPH) administration was tested in the open field arena (Omnitech, Columbus, OH) illuminated at 340 lux as described (Deng et al. 2010 (link)). Mice were placed individually into the open field and baseline locomotion was monitored over 60 min. Animals were removed, injected (i.p.) with vehicle (sterile water, 4 ml/kg; Hospira Inc., Lake Forest IL), or 10, 20 or 30 mg/kg cocaine (Sigma-Aldrich, St. Louis, MO), or 2 or 3 mg/kg AMPH (Sigma-Aldrich), and returned immediately to the open field for 120 min.
For behavioral sensitization, mice were administered 20 mg/kg cocaine or 3 mg/kg AMPH for 5 consecutive days using the same procedure as described above. On day 11, mice were challenged with the same doses of cocaine or AMPH. All results are presented as cumulative distance traveled in 5-min blocks or as cumulative locomotion (pre- and post-injection).
Berezniuk I., Rodriguiz R.M., Zee M.L., Marcus D.J., Pintar J., Morgan D.J., Wetsel W.C, & Fricker L.D. (2017). ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine. Journal of neurochemistry, 143(3), 268-281.
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