Pva 10 k

Methotrexate disodium (MTX Na) (purity ≥ 99.35%) was purchased from Haihang Industry Co. LTD (Shandong, China). Poly(vinylalcohol) (MW= 9–10 kDa, 80% hydrolysed) (PVA 10 K) and Poly(vinylalcohol) (MW=31–50 kDa, 87–89% hydrolysed) (PVA 50 K) were purchased from Sigma-Aldrich (Dorset, UK). Poly(vinylpyrrolidone) (MW=58 kDa) (PVP) was obtained from Ashland (Kidderminster, UK). Ultrapure water was obtained from a water purification system (Elga PURELAB DV 25, Veolia Water Systems, Dublin, Ireland). All other reagents used were of analytical grade.

Long-acting cabotegravir (CAB LA) nanosuspension vials for IM injection with drug content (400 mg/2 mL) and micronized powders of CAB Na were supplied by ViiV Healthcare (Research Triangle Park, NC, USA). Poly(vinyl alcohol), or PVA, of molecular weight (MW) 9 to 10 kDa, 80% hydrolyzed (PVA 10K), and of MW 31 to 50 kDa, 87% to 89% hydrolyzed (PVA 50K), were purchased from Sigma–Aldrich (Dorset, UK). Poly(vinyl pyrrolidone) K29-32 gel (MW 58 kDa) was a gift from Ashland (Kidderminster, UK). Liquid silicone elastomer mix was purchased from Nusil Technology (Buckinghamshire, UK). Ultrapure water was obtained from a water purification system (Elga PURELAB^® DV 25, Veolia Water Systems, Dublin, Ireland). All other chemicals and materials were of analytical reagent grade and supplied by Sigma–Aldrich.