Expression console software version 1.2.1

Manufactured by Thermo Fisher Scientific

Sourced in United States

Expression Console Software (version 1.2.1) is a software application designed for data analysis and visualization. It provides tools for managing and processing data related to gene expression experiments.

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Lab products found in correlation

Rneasy mini kit, by Qiagen (1 mentions) Uv vis spectrophotometer, by Thermo Fisher Scientific (1 mentions)

Spelling variants of this product

Expression Console software (367 citations) Expression Console (354 citations) Expression Console 1.1 software (32 citations) Expression Console software version 1.1 (21 citations) Expression Console Software 1.4 (21 citations) Expression Console version 1.1 (14 citations)

3 protocols using expression console software version 1.2.1

Microarray Gene Expression Analysis

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Total RNA was converted into cDNA, which was fragmented, labeled, and hybridized onto gene chips (Microarray Gene 1.0, Affymetrix, Santa Clara, CA) according to Affymetrix standard protocols. Affymetrix^® Expression Console Software (version 1.2.1) was used for microarray analyses.
Expression data of all probesets detected by microarray analysis have been deposited in Gene Expression omnibus, GPL6244GSE, GSE69814.

Tong J., Xie J., Ren H., Liu J., Zhang W., Wei C., Xu J., Zhang W., Li X., Wang W., Lv D., He J.C, & Chen N. (2015). Comparison of Glomerular Transcriptome Profiles of Adult-Onset Steroid Sensitive Focal Segmental Glomerulosclerosis and Minimal Change Disease. PLoS ONE, 10(11), e0140453.

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Splenic DC Transcriptome Profiling

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For Affymetrix microarray profiling, total RNA was isolated from splenic DCs with TRIzol reagent (Karlsbad Invitrogen, Canada), treated with DNase and then purified with an RNeasy Mini Kit (Qiagen, Hilden, Germany). The quantity and quality of RNA were measured with a UV–Vis spectrophotometer (Thermo, nanodrop 2000, USA) at an absorbance of 260 nm. The mRNA expression profile was detected by GeneChip Mouse Transcriptome Array 1.0 (Affymetrix GeneChip, Santa Clara, CA, USA). Affymetrix Expression Console Software (Version 1.2.1) was used for microarray analysis. To normalize the raw data (CEL files) at the transcript level, robust multiarray average normalization was performed, and then the expression value of each transcript was calculated. The gene-level data were then screened to include only those probe sets that appeared in the ‘core’ meta-probe list representing the RefSeq gene.

Lu Z.Q., Zhang C., Zhao L.J., Dong W., Lv L., Lu Y., Chen X.Y., Zhang J., Liu X.Y., Xiao Z., Chen L.W., Yao Y.M, & Zhao G.J. (2024). Matrix metalloproteinase-8 regulates dendritic cell tolerance in late polymicrobial sepsis via the nuclear factor kappa-B p65/β-catenin pathway. Burns & Trauma, 12, tkad025.

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Transcriptome Profiling of NF2-associated VSs

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Gene expression profiling analysis was performed on an independent cohort of 37 NF2-associated VSs and seven normal peripheral nerves using the Affymetrix Human Transcriptome Array 2.0 Kit (Affymetrix GeneChip, #902280, Santa Clara, CA, United States), as we described previously (Zhao et al., 2018b (link); Zhao et al., 2022 (link)). Sample library preparation, hybridization, and quality control were performed according to Affymetrix-recommended protocols. The microarray analysis was performed using Affymetrix Expression Console Software (version 1.2.1, Santa Clara, CA, United States). Gene expression profiling data can be acquired from the NCBI GEO database (No. GSE108524). For differentially expressed gene (DEG) analysis, the criteria of fold change ≥ 2 and p < 0.05 was used.

Lin J., Li S.W., Zhang J., Chu F.H., Li C.Z., Bie Z.X., Tang H.L., Gao S., Li P., Liao M.T., Xin T.X., Zhao F., Liu P.N, & Ding X. (2022). Qu-Du-San-Jie decoction induces growth inhibition and vascular normalization in NF2-associated vestibular schwannoma. Frontiers in Pharmacology, 13, 941854.

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