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Anti mcl 1 s 19 sc 819

Manufactured by Santa Cruz Biotechnology
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Anti-Mcl-1 (S-19) (sc-819) is a polyclonal antibody that recognizes the Mcl-1 (myeloid cell leukemia 1) protein. Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins. The antibody can be used for the detection of Mcl-1 by various immunological techniques.

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Lab products found in correlation

Anti phospho glycogen synthase ser641, by Cell Signaling Technology (1 mentions) Palmitic acid p5585, by Merck Group (1 mentions) Anti actin c 11 sc1615, by Santa Cruz Biotechnology (1 mentions) Anti bcl 2 c 2, by Santa Cruz Biotechnology (1 mentions) Anti β actin, by Abcam (1 mentions)

2 protocols using anti mcl 1 s 19 sc 819

1

Palmitic Acid and JNK Inhibition

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Palmitic acid (P5585) was purchased from Sigma-Aldrich. The JNK inhibitor SP600125 (420119) was purchased from Calbiochem (San Diego, CA, USA). Anti-Bim (C34C5) rabbit monoclonal antibody (mAb) (#2933), anti-PARP (#9542), anti-JNK (#9252), anti-phospho-JNK (Thr183/Tyr185) (#9251), and anti-phospho-glycogen synthase (Ser641) (#3891) rabbit polyclonal antibodies were purchased from Cell Signaling, Inc. (Danvers, MA, USA). Anti-Mcl-1 (S-19) (sc-819) and anti-actin (C-11) (sc-1615) antibodies were purchased from Santa Cruz Biotechnology, Inc. (Dallas, TX, USA). Anti-cIAP-1 (AF8181) antibody was purchased from R&D Systems (Minneapolis, MN, USA).
Takaki H., Akazawa Y., Kido Y., Morishita M., Honda T., Shibata H., Miuma S., Miyaaki H., Taura N., Kondo H, & Nakao K. (2017). Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 23, 4526-4532.
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2

Venetoclax and S63845 Effects on MCL1 and Bcl-2

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MV4-11 cells were treated for four hours with 10 nM Venetoclax, 5 nM S63845 or the drug combination. Cell lysates were prepared, separated by sodium dodecyl sulphate polyacrylamide gel electrophoresis, and transferred to nitrocellulose membranes. Detection antibodies included anti-MCL1 (S-19, sc-819) and anti-Bcl-2 (C-2) from Santa Cruz Biotechnology, Santa Cruz, CA, USA and anti-β-actin from Abcam, Cambridge, UK.
Grundy M., Balakrishnan S., Fox M., Seedhouse C.H, & Russell N.H. (2018). Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget, 9(102), 37777-37789.
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