Porcine brain lipids

Porcine brain lipids and ovine cholesterol was purchased from Avanti Polar Lipids (Alabaster, AL, USA) and bovine MBP from Sigma-Aldrich (St. Louis, MO, USA). Liposomes of native and EAE modified lipid composition have been prepared via extrusion through a membrane with 100 nm diameter pores. In Table S6 the lipid compositions of the two membrane types are depicted. To calculate scattering curves of the native and EAE membranes averaged x-ray/neutron scattering length densities (SLDs) of the head and chain sections were used (averaged SLD values given in Table S7). For the calculation of these average SLDs the fatty chain length composition of the different lipid molecules (see Table S8) was considered. Molar volumes $V_{\text{m}}$ , coherent neutron scattering lengths $b_{\text{coh}}$ of their moieties and the neutron and x-ray SLDs of the individual head groups and chain components are given in Table S9.

Porcine brain lipids (PC, PE, PS, and SM) and ovine cholesterol were purchased from Avanti Polar Lipids (Alabaster, AL, USA) and bovine MBP from Sigma-Aldrich (St. Louis, MO, USA).