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C57bl 6 and 2d2 mice

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C57BL/6 and 2D2 mice are laboratory animal models used in biomedical research. C57BL/6 mice are a commonly used inbred strain, while 2D2 mice are a transgenic strain. Both are provided by Jackson ImmunoResearch for use in various research applications.

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Lab products found in correlation

Rag2 γc mice, by Taconic Biosciences (2 mentions) Cd4 cre female mice, by Taconic Biosciences (2 mentions)

Close spelling variants of this product

C57BL/6 mice (4025 citations) C57BL/6 (2462 citations) 2D2 mice (8 citations)

2 protocols using c57bl 6 and 2d2 mice

1

Conditional Deletion of Jmjd3 in Mice

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Jmjd3flox/flox (Jmjd3f/f) mice were generated by targeting exons 15-21 (encoding the JmjC-catalytic domain) using a Cre-LoxP system. Eight-week-old Jmjd3f/f male mice were crossed with eight-week-old CD4-Cre female mice (Taconic) to generate Jmjd3 cKO mice. C57BL/6 and 2D2 mice were obtained from the Jackson Laboratory. Rag2−/−γc−/− mice were purchased from Taconic. Foxp3-GFP reporter mice were kindly provided by Dr. Alexander Rudensky (Memorial Sloan-Kettering Cancer Center, NY). All mice were rederived by standard embryo transfer and maintained in pathogen-free animal facilities at Baylor College of Medicine and the Houston Methodist Research Institute. This study was reviewed and approved by Institutional Animal Care and Use Committee at Baylor College of Medicine and the Houston Methodist Research Institute.
Li Q., Zou J., Wang M., Ding X., Chepelev I., Zhou X., Zhao W., Wei G., Cui J., Zhao K., Wang H.Y, & Wang R.F. (2014). Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T cell differentiation. Nature communications, 5, 5780.
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2

Conditional Deletion of Jmjd3 in Mice

Check if the same lab product or an alternative is used in the 5 most similar protocols
Jmjd3flox/flox (Jmjd3f/f) mice were generated by targeting exons 15-21 (encoding the JmjC-catalytic domain) using a Cre-LoxP system. Eight-week-old Jmjd3f/f male mice were crossed with eight-week-old CD4-Cre female mice (Taconic) to generate Jmjd3 cKO mice. C57BL/6 and 2D2 mice were obtained from the Jackson Laboratory. Rag2−/−γc−/− mice were purchased from Taconic. Foxp3-GFP reporter mice were kindly provided by Dr. Alexander Rudensky (Memorial Sloan-Kettering Cancer Center, NY). All mice were rederived by standard embryo transfer and maintained in pathogen-free animal facilities at Baylor College of Medicine and the Houston Methodist Research Institute. This study was reviewed and approved by Institutional Animal Care and Use Committee at Baylor College of Medicine and the Houston Methodist Research Institute.
Li Q., Zou J., Wang M., Ding X., Chepelev I., Zhou X., Zhao W., Wei G., Cui J., Zhao K., Wang H.Y, & Wang R.F. (2014). Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T cell differentiation. Nature communications, 5, 5780.
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