Palbociclib isethionate

Manufactured by Selleck Chemicals

Palbociclib isethionate is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6). It is primarily used as a research tool in cell-based and in vivo studies to investigate the role of CDK4 and CDK6 in cell cycle regulation and proliferation.

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Lab products found in correlation

Recombinant human insulin, by Merck Group (2 mentions) Rapamycin, by Thermo Fisher Scientific (2 mentions) Sp600125, by Apexbio (2 mentions) 3xflag peptide, by Apexbio (2 mentions) Nocodazole, by Apexbio (1 mentions) Ribociclib, by Chemietek (1 mentions) Trametinib, by LC Laboratories (1 mentions) Binimetinib, by LC Laboratories (1 mentions) Anisomycin, by Cayman Chemical (1 mentions) Trametinib, by Selleck Chemicals (1 mentions) Phorbol myristate acetate (pma), by Merck Group (1 mentions)

3 protocols using palbociclib isethionate

Dissolution of Therapeutic Compounds

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Palbociclib isethionate (Selleckchem) was dissolved in water. Rapamycin (Alfa Aesar) and SP600125 (ApexBio) were dissolved in DMSO. Human recombinant insulin was purchased from Sigma. Nocodazole and 3XFLAG peptide were purchased from ApexBio. All reagents were used as received.

Mitchell D.C., Menon A, & Garner A.L. (2019). Cyclin-Dependent Kinase 4 inhibits the translational repressor 4E-BP1 to promote cap-dependent translation during mitosis–G1 transition. FEBS letters, 594(8), 1307-1318.

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Kinase Inhibitors for Cancer Research

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Trametinib and binimetinib (MEK162) were purchased from LC Laboratories. Ribociclib (LEE011) was purchased from Chemietek. Palbociclib isethionate was purchased from Selleckchem. Drug stocks were dissolved in DMSO at 10 mM and stored at −20 °C.

Maust J.D., Frankowski-McGregor C.L., Bankhead A I.I.I., Simeone D.M, & Sebolt-Leopold J.S. (2018). Cyclooxygenase-2 Influences Response to Co-Targeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers. Molecular cancer therapeutics, 17(12), 2495-2506.

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Preparation of Kinase Inhibitor Solutions

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Palbociclib Isethionate (Selleckchem) was dissolved in water to 10 mM. Trametinib (Selleckchem), Rapamycin (Alfa Aesar), and SP600125 (ApexBio) were dissolved in DMSO. Human recombinant insulin was purchased from Sigma, PMA (Phorbol-12-Myristate-13-Acetate) was purchased from Acros. Anisomycin was purchased from Cayman Chemical. 3XFLAG peptide was purchased from ApexBio. All reagents were used as received.

Mitchell D.C., Menon A, & Garner A.L. (2019). Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. Cell chemical biology, 26(7), 980-990.e8.

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