The amino alcohol compound (JF16) was purchased from Enamine, Ltd. (Kievska Region, Ukraine) with purity > 90%. Mefloquine (MEF, Sigma, United States), ursolic acid (UA, Sigma) and other reagents (unless specifically stated) were obtained from Sigma (United States).
Mefloquine mef
Manufactured by Merck Group
Sourced in United States
Mefloquine (MEF) is a synthetic antimalarial drug used for the treatment and prevention of malaria. It functions as a blood schizonticide, targeting and inhibiting the growth of Plasmodium parasites within the human host's red blood cells. The core function of Mefloquine is to provide effective antimalarial therapy.
Automatically generated - may contain errors
Lab products found in correlation
Ursolic acid, by Merck Group (1 mentions)
Meclofenamic acid, by Merck Group (1 mentions)
Flecainide acetate, by Merck Group (1 mentions)
Ikk 16, by Selleck Chemicals (1 mentions)
Hct116, by American Type Culture Collection (1 mentions)
Sw620, by American Type Culture Collection (1 mentions)
Ht 29, by American Type Culture Collection (1 mentions)
Tumor necrosis factor alpha tnf α, by Merck Group (1 mentions)
Doxorubicin dox, by Merck Group (1 mentions)
Niclosamide nic, by Merck Group (1 mentions)
Dulbeccos s modified eagle medium dmem, by Thermo Fisher Scientific (1 mentions)
Streptomycin, by Thermo Fisher Scientific (1 mentions)
Penicillin, by Thermo Fisher Scientific (1 mentions)
4 protocols using mefloquine mef
1
Synthesis and Evaluation of JF16 Compound
2
Intraperitoneal Drug Administration for Imaging
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Mefloquine (MEF; Sigma-Aldrich), meclofenamic acid (MFA; Sigma-Aldrich) and flecainide acetate (FLE; Sigma-Aldrich) were freshly prepared in 0.9% NaCl with 2% DMSO and administered intraperitoneally (i.p.) at the same dose of 1 mg/kg in a volume of 5 mL/kg, 2.5 h before imaging. Control animals received the vehicle only under the very same conditions.
3
Colorectal Cancer Cell Line Maintenance
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Colorectal cancer cell lines HT‐29, HCT116, RKO, SW620 and Lovo were purchased from ATCC (Manassas, VA, USA). HEK293T cell line was kindly provided by Dr Huashun Li from Tongji University, Shanghai, China. All CRC cell lines and HEK293T were maintained in DMEM supplemented with 10% FBS, 100 μg/mL penicillin, and 100 units/mL streptomycin. The 104‐compound library and IKK‐16 were purchased from Selleck Chemicals (Houston, TX, USA). Doxorubicin (DOX), mefloquine (Mef), and tumor necrosis factor alpha (TNF‐α) were purchased from Sigma‐Aldrich (St Louis, MO, USA).
4
Anti-parasitic Drug Screening Protocol
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If not stated otherwise, all chemicals were purchased from Sigma-Aldrich (Buchs, Switzerland). Dulbeccos’s modified Eagle medium (DMEM) and Penicillin and Streptomycin (10’000 Units/mL Penicillin, 10’000 μg/mL Streptomycin) were purchased from Gibco (Fisher Scientific AG, Reinach, Switzerland). Fetal bovine serum (FBS) and Trypsin/EDTA (0.05% Trypsin/ 0.02% EDTA) were purchased from Bioswisstec (Schaffhausen, Switzerland). If not stated otherwise all plastic ware was purchased from Sarstedt (Sevelen, Switzerland). ABZ, buparvaquone (BPQ), mefloquine (MEF) and niclosamide (NIC) were all purchased from Sigma-Aldrich, MMV665807 (MMV-X) was from Princeton Biomolecular Research (South Brunswick Township, New Jersey, USA) and monepantel (MPT) was obtained from LuBioScience GmbH (Zürich, Switzerland). The drugs were prepared as 10.000 parts per million (ppm) and 40 mM stocks in DMSO and stored as aliquots at -20°C.
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