Elecsyscobase 601

Manufactured by Roche

Sourced in Belgium

The Elecsyscobase 601 is a laboratory instrument designed for automated immunoassay analysis. It is capable of performing a variety of immunoassay tests for the detection and measurement of various analytes in biological samples.

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Lab products found in correlation

Elecsys cea kit, by Roche (1 mentions) Elecsys ca19 9 kit, by Roche (1 mentions) Elecsys kit, by Roche (1 mentions)

4 protocols using elecsyscobase 601

CSF Biomarker Measurement Protocol

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CSF Aβ₄₀, CSF Aβ₄₂ and Tau,
phosphorylated Tau181 (p-Tau) measurement were completed using the Roche Elecsys
cobase 601 fully automated immunoassay platform at the ADNI biomarker core
(University of Pennsylvania). CSF biomarker samples were acquired in the 30-days
interval of the imaging visit. All samples were aliquoted and stored at
−80°C until assay. A 2D-ultra performance liquid chromatography
tandem mass spectroscopy (UPLC/MS -MS) platform was used (Kang et al., 2015 (link); Korecka et al., 2014 (link)), which was calibrated with a surrogate
calibrator matrix prepared from artificial CSF plus 4 mg/mL bovine serum
albumin.

Sepehrband F., Barisano G., Sheikh-Bahaei N., Choupan J., Cabeen R.P., Lynch K.M., Crawford M.S., Lan H., Mack W.J., Chui H.C., Ringman J.M, & Toga A.W. (2020). Volumetric Distribution of Perivascular Space in Relation to Mild Cognitive Impairment. Neurobiology of aging, 99, 28-43.

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Hyperosteogeny Tissue Analysis Protocol

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An X-ray dental panorama was performed on the oral cavity and an X-ray examination was performed on the right forearm of the proband. Pathological sections were taken from hyperosteogeny tissue of the mandibular bone, and the right tibial. Hyperosteogeny tissues were harvested and stored at formalin for further analyses. Biochemical tests were performed on the 3 ml peripheral blood obtained from the proband and his mother. After collecting peripheral blood, the serum was separated via centrifugation at 1,610 x g for 5 min at room temperature. The electrochemiluminescence immunoassay and the kits for the instrument was performed using Elecsys Cobas e 601 (Roche Diagnostics) to detect the serum levels of carcinoembryonic antigen (CEA; Elecsys CEA kit) and carbohydrate antigens including CA15-3 (Elecsys CA15-3 kit), CA19-9 (Elecsys CA19-9 kit) and CA72-4 (Elecsys CA72-4 kit). All Elecsys kits were all obtained from Roche Diagnostics GmbH.

Cai D., He F., Xu X., Xiong F, & Zhang L. (2021). APC c.4621C>T variant causing Gardner's syndrome in a Han Chinese family may be inherited through maternal mosaicism. Experimental and Therapeutic Medicine, 21(5), 488.

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Cerebrospinal Fluid Biomarker Analysis

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CSF was sampled by lumbar puncture, with CSF Aβ, CSF T-tau, and CSF P-tau measured at the ADNI Biomarker Core Laboratory (University of Pennsylvania) using a complex platform (xMAP; Luminex Corporation) with Innogenetics (INNO-BIA AlzBio3; Ghent, Belgium; for research use only reagents) immune assay kit-based reagents and analyzed on an automatic Elecsys cobas e 601 instrument (F. Hoffmann-La Roche) by an advanced technology known as electrochemiluminescence immunoassays (Elecsys; Roche Diagnostics, F. Hoffmann-La Roche, Basel, Switzerland).

Hou J.H., Ou Y.N., Xu W., Zhang P.F., Tan L, & Yu J.T. (2022). Association of peripheral immunity with cognition, neuroimaging, and Alzheimer’s pathology. Alzheimer's Research & Therapy, 14, 29.

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Serum AFP Variation as a Biomarker

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The serum AFP concentration was measured at baseline (before the initiation of combined therapy) and at every follow-up visit using an electro chemiluminescence immunoassay (ElecsysCobas e601, Roche). The AFP variation rate (ΔAFP) was defined as the percentage of change between the baseline and the nadir within 1–2 months after combination therapy.

The AFP response was defined as an ΔAFP(%) greater than the cutoff point (ΔAFP(%) > cutoff point), whereas AFP non-response was defined as an AFP decrease rate less than the AFP variation cutoff point (ΔAFP(%) < cutoff point). The researcher who extracted the AFP data was blinded to the survival outcome.

Liu L., Zhao Y., Jia J., Chen H., Bai W., Yang M., Yin Z., He C., Zhang L., Guo W., Niu J., Yuan J., Cai H., Xia J., Fan D, & Han G. (2016). The Prognostic Value of Alpha-Fetoprotein Response for Advanced-Stage Hepatocellular Carcinoma Treated with Sorafenib Combined with Transarterial Chemoembolization. Scientific Reports, 6, 19851.

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