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Palbociclib cdk4 6

Manufactured by Selleck Chemicals
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Palbociclib (CDK4/6) is a laboratory research chemical used in the study of cell cycle regulation. It functions as a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), which are essential for cell cycle progression. This compound is commonly used in cell-based assays and preclinical research to investigate the role of CDK4/6 in various biological processes.

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Lab products found in correlation

Total cdk4, by Cell Signaling Technology (1 mentions) Total cdk6, by Cell Signaling Technology (1 mentions) Phospho cdk6 antibody, by Thermo Fisher Scientific (1 mentions) Vinculin antibody, by Merck Group (1 mentions) Phospho rb, by Cell Signaling Technology (1 mentions)

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Palbociclib (195 citations)

2 protocols using palbociclib cdk4 6

1

Comprehensive Inhibitor Evaluation Protocol

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All inhibitors, including Navitoclax (BCL-2/BCL-xL), Trametinib (MEK), Palbociclib (CDK4/6), were obtained from Selleckchem.
Lin H.T., Takagi M., Kubara K., Yamazaki K., Michikawa F., Okumura T., Naruto T., Morio T., Miyazaki K., Taniguchi H, & Otsu M. (2024). Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells. Stem Cell Research & Therapy, 15, 106.
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2

Protein Expression Analysis of CDK Regulators

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PPM1A (PP2C-α), total and phospho-CDK2, total CDK4, total CDK6, phospho-Rb, p21, and p27 antibodies were obtained from Cell Signaling Technology, Inc. (Danvers, MA). The phospho-pan CDK antibody was obtained from Santa Cruz Bioscience (Dallas, TX). The phospho-CDK6 antibody was obtained from Thermo Scientific (Waltham, MA). The total Rb antibody was obtained from BD Transduction Laboratories (Lexington, KY). The vinculin antibody was obtained from Sigma-Aldrich Corp. (St. Louis, MO). Anti-mouse and anti-rabbit HRP secondary antibodies were purchased from GE Healthcare Bio-Sciences Corp. (Piscataway, NJ). Anti-mouse and anti-rabbit IRDye secondary antibodies were purchased from LI-COR Biosciences (Lincoln, NE). CDK inhibitors Palbociclib (CDK4/6) and K03861 (CDK2) were purchased from Selleck Chemical (Houston, TX).
Mazumdar A., Tahaney W.M., Reddy Bollu L., Poage G., Hill J., Zhang Y., Mills G.B, & Brown P.H. (2019). The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression. NPJ Breast Cancer, 5, 22.
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