Genetically modified tissue-specific mDia2 knockout mice with a C57/BL6 background were described previously25 (link),26 (link). Congenic mice carrying CD45.1 antigen were purchased from Charles River (B6-LY-5.2/Cr, strain code: 564). C57/BL6 WT mice, CAG-Cas9 transgenic mice (stock #026179), Mx-Cre mice (stock #003556), and Vav-Cre mice (stock #008610) were purchased from the Jackson Laboratory. All the experiments involving animals were conducted in accordance with the Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care and Use Committee at Northwestern University.
Cag cas9 transgenic mice
Manufactured by Jackson ImmunoResearch
CAG-Cas9 transgenic mice express Cas9 protein under the control of the CAG promoter. These mice can be used to generate genetically engineered mice by introducing guide RNAs targeting specific genes of interest.
Automatically generated - may contain errors
Lab products found in correlation
Wt c57bl 6 mice, by Jackson ImmunoResearch (1 mentions)
Vav cre mice, by Jackson ImmunoResearch (1 mentions)
Mx cre mice, by Jackson ImmunoResearch (1 mentions)
Lrrk2 g2019s bac mice, by Jackson ImmunoResearch (1 mentions)
C57bl 6, by Jackson ImmunoResearch (1 mentions)
C57bl 6 mice, by Jackson ImmunoResearch (1 mentions)
2 protocols using cag cas9 transgenic mice
1
Genetically Modified Mice for Research
2
Transgenic Mouse Model for LRRK2 G2019S
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Mouse husbandry and procedures were performed in accordance with institutional guidelines and approved by the Stanford Administrative Panel on Animal Care (APLAC). Heterozygous human LRRK2 G2019S BAC-transgenic mice (The Jackson Laboratory, cat# 018785) were maintained on a C57BL/6 background (The Jackson Laboratory, cat# 000664). LRRK2 G2019S mice and wild-type litter mates were used for in vivo experiments. C57BL/6 mice, LRRK2 G2019S BAC mice and CAG–Cas9 transgenic mice (Jackson Laboratory cat# 024858) were used for time-mating and primary neuron cultures.
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